BENZYL 1-PIPERAZINECARBOXYLATE

Product Name: BENZYL 1-PIPERAZINECARBOXYLATE
CAS No.: 31166-44-6
Chemical Name: BENZYL 1-PIPERAZINECARBOXYLATE
Synonyms: BENZYL PIPERAZINE-1-CARBOXYLATE;1-Cbz-Piperazine;1-Z-PIPERAZINE;N-CBZ-PIPERAZINE;Boc-Cys-Boc;1-Z-Piperazine 98%;1-Cbz-piperazine, 97%;LABOTEST-BB LT00138040;1-Cbz-piperazine, 95+%;1-carbobenzoxypiperazine
CBNumber: CB9469015
Molecular Formula: C12H16N2O2
Formula Weight: 220.27
MOL File: 31166-44-6.mol

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BENZYL 1-PIPERAZINECARBOXYLATE Property

Boiling point:: 158-161 °C1.4 mm Hg(lit.)
Density: 1.142 g/mL at 25 °C(lit.)
refractive index: n20/D 1.546(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Sparingly)
pka: 8.44±0.10(Predicted)
form: Oil
color: Clear Colourless to Pale Yellow
BRN: 179500
InChI: InChI=1S/C12H16N2O2/c15-12(14-8-6-13-7-9-14)16-10-11-4-2-1-3-5-11/h1-5,13H,6-10H2
InChIKey: CTOUWUYDDUSBQE-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCNCC1
CAS DataBase Reference: 31166-44-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-23
HS Code: 29335990
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 456926
Product name: 1-Z-Piperazine
Purity: 98%
Packaging: 5ml
Price: $52
Updated: 2025/07/31

Sigma-Aldrich

Product number: 456926
Product name: 1-Z-Piperazine
Purity: 98%
Packaging: 25ml
Price: $295
Updated: 2025/07/31

TCI Chemical

Product number: C2178
Product name: 1-Carbobenzoxypiperazine
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: C2178
Product name: 1-Carbobenzoxypiperazine
Purity: >95.0%(GC)(T)
Packaging: 25g
Price: $304
Updated: 2025/07/31

TRC

Product number: C227775
Product name: 1-Cbz-piperazine
Packaging: 25g
Price: $180
Updated: 2021/12/16

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BENZYL 1-PIPERAZINECARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellowish liquid

Uses

1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter.

Synthesis

30.16 g (0.1536 mol) of piperazine hexahydrate was placed in an ice bath with 150 mL of water and 185 mL of tert-butanol. in an ice bath, cooled to 5?? C. 24.4 mL of 2.5 N sodium hydroxide was added dropwise, followed by the slow dropwise addition of 13.5 g (0.061 mol) of Di-tert-butoxyformic anhydride and kept stirring at 5-6??C for one hour, stirred overnight at room temperature, evaporated off the tert-butanol under reduced pressure, over filtration to remove the biprotected solid (melting point 162-163??C), the filtrate was extracted three times with dichloromethane, washed with water, washed with salt, anhydrous Magnesium sulfate was dried, filtered through anhydrous sodium sulfate, concentrated under reduced pressure, and filtered by cooling the crystallization in ice water to give the white solid product tert-butyl piperazine-1-carboxylate (solubility point 47-49??C).

Ten grams (54 mmol) of tert-butyl piperazine-1-carboxylate and 8.2 mL of triethylamine were dissolved in 120 mL of di- chloromethane, cooled to 0??C, 9.2 g (54 mmol) of benzyloxycarbonyl chloride and 100 mL of dichloromethane were added dropwise to the solution, stirred at room temperature until the raw material disappeared, concentrated under reduced pressure, added ethyl acetate, washed with water, washed with sodium bicarbonate, washed with salt, dried over anhydrous sodium sulfate, spun off the solvent, and separated on a short column to obtain the product piperazine-1-carboxylic acid tert-butyl ester-4-carboxylic acid benzyl ester.

Dissolve 4.14 g (12.9 mmol) of tert-butyl piperazine-1-carboxylate-4-carboxylic acid benzyl ester in 30 ml of dichloromethane, cool to 0??C, add 10 ml of trifluoroacetic acid, stir at room temperature until the raw material disappeared, concentrate under reduced pressure. Add 1N sodium hydroxide 150 ml neutralization, extracted twice with dichloromethane, anhydrous magnesium sulfate dry, spin off the solvent to get the product benzyl-1-piperazine carbonate.

BENZYL 1-PIPERAZINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Piperazine Benzyl chloroformate Sodium hydroxide

Preparation Products

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BENZYL 1-PIPERAZINECARBOXYLATE Suppliers

Americas 1 Belgium 2 Canada 1 China 164 Europe 1 Germany 5 India 10 Japan 3 Switzerland 1 United Kingdom 3 United States 34 Global 225

ITIC MEDCHEM(SUZHOU) CO.,LTD.

Tel: 0512-68323967 18015559028
Fax: +86-512-69200360
Email: sales@iticmedchem.com
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Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
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Email: chengzhenyong@cdfirster.com
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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

Tel: 021-021-58432009 400-005-6266
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
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View Lastest Price from BENZYL 1-PIPERAZINECARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Benzyl 1-piperazinecarboxylate 31166-44-6
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Hebei Yanxi Chemical Co., Ltd.

Product: BENZYL 1-PIPERAZINECARBOXYLATE 31166-44-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Shaanxi Dideu Medichem Co. Ltd

Product: BENZYL 1-PIPERAZINECARBOXYLATE 31166-44-6
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-20

31166-44-6, BENZYL 1-PIPERAZINECARBOXYLATERelated Search:

Mono-tert-butyl succinate 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE Methyl pyruvate 1-BOC-4-CBZ-PIPERAZINE-2-CARBOXYLIC ACID 4-N-BOC-1-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER 4-BOC-1-CBZ-PIPERAZINE-2-CARBOXYLIC ACID,4-N-BOC-1-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 4-Cbz-piperazine-2-carboxylate methyl ester (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid BENZYL 1-PIPERAZINECARBOXYLATE (R)-N-1-BOC-N-4-CBZ-2-PIPERAZINE CARBOXYLIC ACID 1-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER TERT-BUTYL 4-BENZYL-1-PIPERAZINECARBOXYLATE,1-Benzyl-4-(tert-butoxycarbonyl)piperazine~tert-Butyl 4-benzyl-1-piperazinecarboxylate 4-CBZ-PIPERAZINE-2-CARBOXYLIC ACID,4-CBZ-PIPERAZINE-2-(+/-)-CARBOXYLIC ACID W 77 4-METHYL-3-PYRROLIDIN-1-YLMETHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER 4-N-CBZ-2-HYDROXYMETHYL-PIPERAZINE 4-CBZ-PIPERAZINE-2-(R)-CARBOXYLIC ACID

1-Z-PIPERAZINE

1-(BENZYLOXYCARBONYL)PIPERAZINE

LABOTEST-BB LT00138040

BENZYL 1-PIPERAZINECARBOXYLATE

BENZYL PIPERAZINE-1-CARBOXYLATE

Benzyl 1-piperazinecarboxylate,97%

1-Cbz-Piperazine

1-carbobenzoxypiperazine

1-(Benzyloxycarbonyl)piperazine, 1-Cbz-Piperazine, Benzyl piperazine-1-carboxylate

1-Cbz-piperazine Benzyl Piperazine-1-carboxylate Piperazine-1-carboxylic Acid Benzyl Ester

Boc-Cys-Boc

1-Z-Piperazine 98%

1-Cbz-piperazine, 95+%

1-Piperazinecarboxylicacid, phenylmethyl ester

PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER

N-CBZ-PIPERAZINE

Benzyl-1-piperzinecarboxylate

Piperazine, N-CBZ protected 97%

Piperazine, N-CBZ protected

1-Carbobenzoxypiperazine &gt

phenylmethyl 1-piperazinecarboxylate

1-Cbz-piperazine, 97%

N-CBz-piperazine, 98%min

31166-44-6

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