BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE

Product Name: BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
CAS No.: 78818-15-2
Chemical Name: BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
Synonyms: BUTTPARK 32\04-69;4-CBZ-PIPERAZINONE;N-CBZ-PIPERAZINONE;4-Z-PIPERAZIN-2-ONE;1-Z-3-OXOPIPERAZINE;N'-Z-PIPERAZIN-2-ONE;1-CBZ-3-OXOPIPERAZINE;1-Z-3-oxopiperazine;N-CARBOXYBENZYLOXYPIPERAZINONE;1-Carbobenzoxy-3-oxopiperazine
CBNumber: CB0413217
Molecular Formula: C12H14N2O3
Formula Weight: 234.25
MOL File: 78818-15-2.mol

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BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Property

Melting point:: 118-120°C
Boiling point:: 459.8±45.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 14.98±0.20(Predicted)
color: White to Orange to Green
InChI: 1S/C12H14N2O3/c15-11-8-14(7-6-13-11)12(16)17-9-10-4-2-1-3-5-10/h1-5H,6-9H2,(H,13,15)
InChIKey: BAHFPJFBMJTOPU-UHFFFAOYSA-N
SMILES: O=C1CN(CCN1)C(=O)OCc2ccccc2
CAS DataBase Reference: 78818-15-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 667641
Product name: 1-Z-3-oxopiperazine
Purity: 97%
Packaging: 5g
Price: $254
Updated: 2023/06/20

TCI Chemical

Product number: B4100
Product name: Benzyl 3-Oxopiperazine-1-carboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: B4100
Product name: Benzyl 3-Oxopiperazine-1-carboxylate
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $183
Updated: 2025/07/31

TRC

Product number: B521438
Product name: Benzyl 3-Oxopiperazine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 263594
Product name: 4-Benzyloxycarbonyl-2-piperazinone
Packaging: 5g
Price: $656
Updated: 2021/12/16

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BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Benzyl 3-oxopiperazine-1-carboxylate is a useful research reagent for organic synthesis and other chemical processes.

Synthesis

5625-67-2

501-53-1

78818-15-2

Step 2: Synthesis of benzyl 3-oxopiperazine-1-carboxylate Sodium carbonate (24.77 g, 233.73 mmol, 3.00 eq.) and piperazin-2-one (7.80 g, 77.91 mmol, 1.00 eq.) were dissolved in a solvent mixture of ethyl acetate (70.00 mL) and water (70.00 mL) at 0 °C. Subsequently, benzyl chloroformate (16.79 g, 93.49 mmol, 13.99 mL, 95% purity, 1.20 eq.) was slowly added. The reaction mixture was stirred at 30 °C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was extracted with ethyl acetate (80 mL x 3). The organic layers were combined, washed with saturated aqueous sodium chloride (80 mL x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by pulping (petroleum ether: ethyl acetate= 20:1,80mL) and filtered after stirring at 30°C for 15 min. The solid was dried under vacuum to obtain 4-Benzyloxycarbonyl-2-piperazinone (15.50 g, 66.17 mmol, 84.93% yield) as a white solid.

References

[1] Journal of Organic Chemistry, 1991, vol. 56, # 11, p. 3715 - 3719
[2] Tetrahedron, 2010, vol. 66, # 18, p. 3370 - 3377
[3] Patent: EP3269715, 2018, A1. Location in patent: Paragraph 0238; 0239
[4] European Journal of Medicinal Chemistry, 2017, vol. 132, p. 26 - 41
[5] European Journal of Medicinal Chemistry, 1981, vol. 16, # 3, p. 229 - 232

BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Suppliers

Americas 1 Belgium 1 China 96 Europe 1 France 1 Germany 4 India 10 Japan 1 Switzerland 2 United Kingdom 14 United States 31 Global 162

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View Lastest Price from BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 78818-15-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 78818-15-2
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-09

78818-15-2, BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATERelated Search:

4-BENZYLOXY-3-METHOXYBENZYL ALCOHOL 4-benzyl-3,5-dimethylbenzonitrile 4-N-BENZYL-2-HYDROXYMETHYLPIPERAZINE 2-Piperazinone 1-Cbz-4-Piperidone Ethyl N-piperazinecarboxylate BENZYL 2-(2-ETHOXY-2-OXOETHYL)-3-OXOPIPERAZINE-1-CARBOXYLATE BENZYL 1-PIPERAZINECARBOXYLATE METHYL PIPERAZINE-1-CARBOXYLATE BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE N-(HYDROXYMETHYL)PIPERAZINE 1-PIPERAZINECARBOXYLIC ACID

3-OXOPIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER

4-Z-PIPERAZIN-2-ONE

4-BENZYLOXYCARBONYL-2-PIPERAZINONE

4-BENZYLOXYCARBONYLPIPERAZIN-2-ONE

1-Piperazinecarboxylicacid, 3-oxo-, phenylmethyl ester

1-<I>Z</I>-3-oxopiperazine

N'-Z-PIPERAZIN-2-ONE

1-Z-3-OXOPIPERAZINE

4-CBZ-PIPERAZINONE

BUTTPARK 32\04-69

BENZYL 3-OXOTETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE

Piperazin-2-one, N4-CBZ protected

1-CBZ-3-OXOPIPERAZINE

N-CBZ-PIPERAZINONE

N-CARBOXYBENZYLOXYPIPERAZINONE

3-Oxopiperazine-1-carboxylic acid benzyl ester, 4-Benzyloxycarbonyl-2-piperazinone

Benzyl 3-oxopiperazine-1-carboxylate, 4-[(Benzyloxy)carbonyl]piperazin-2-one

4-Benzyloxycarbonyl-2-oxopiperazine

Benzyl 3-Oxopiperazine-1-carboxylate &gt

1-Benzyloxycarbonyl-3-oxopiperazine

1-Carbobenzoxy-3-oxopiperazine

78818-15-2

C12H14N2O3

Piperazines

Heterocyclic Building Blocks

Building Blocks

pharmacetical

piperazines

Building Blocks

C12

Chemical Synthesis

Heterocyclic Building Blocks