BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
- Product Name
- BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
- CAS No.
- 78818-15-2
- Chemical Name
- BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
- Synonyms
- BUTTPARK 32\04-69;4-CBZ-PIPERAZINONE;N-CBZ-PIPERAZINONE;4-Z-PIPERAZIN-2-ONE;1-Z-3-OXOPIPERAZINE;N'-Z-PIPERAZIN-2-ONE;1-CBZ-3-OXOPIPERAZINE;1-Z-3-oxopiperazine;N-CARBOXYBENZYLOXYPIPERAZINONE;1-Carbobenzoxy-3-oxopiperazine
- CBNumber
- CB0413217
- Molecular Formula
- C12H14N2O3
- Formula Weight
- 234.25
- MOL File
- 78818-15-2.mol
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Property
- Melting point:
- 118-120°C
- Boiling point:
- 459.8±45.0 °C(Predicted)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 14.98±0.20(Predicted)
- color
- White to Orange to Green
- InChIKey
- BAHFPJFBMJTOPU-UHFFFAOYSA-N
- CAS DataBase Reference
- 78818-15-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 667641
- Product name
- 1-Z-3-oxopiperazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $254
- Updated
- 2023/06/20
- Product number
- B4100
- Product name
- Benzyl 3-Oxopiperazine-1-carboxylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- B4100
- Product name
- Benzyl 3-Oxopiperazine-1-carboxylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $183
- Updated
- 2025/07/31
- Product number
- B521438
- Product name
- Benzyl 3-Oxopiperazine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 263594
- Product name
- 4-Benzyloxycarbonyl-2-piperazinone
- Packaging
- 5g
- Price
- $656
- Updated
- 2021/12/16
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Benzyl 3-oxopiperazine-1-carboxylate is a useful research reagent for organic synthesis and other chemical processes.
Synthesis
5625-67-2
501-53-1
78818-15-2
Step 2: Synthesis of benzyl 3-oxopiperazine-1-carboxylate Sodium carbonate (24.77 g, 233.73 mmol, 3.00 eq.) and piperazin-2-one (7.80 g, 77.91 mmol, 1.00 eq.) were dissolved in a solvent mixture of ethyl acetate (70.00 mL) and water (70.00 mL) at 0 °C. Subsequently, benzyl chloroformate (16.79 g, 93.49 mmol, 13.99 mL, 95% purity, 1.20 eq.) was slowly added. The reaction mixture was stirred at 30 °C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was extracted with ethyl acetate (80 mL x 3). The organic layers were combined, washed with saturated aqueous sodium chloride (80 mL x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by pulping (petroleum ether: ethyl acetate= 20:1,80mL) and filtered after stirring at 30°C for 15 min. The solid was dried under vacuum to obtain 4-Benzyloxycarbonyl-2-piperazinone (15.50 g, 66.17 mmol, 84.93% yield) as a white solid.
References
[1] Journal of Organic Chemistry, 1991, vol. 56, # 11, p. 3715 - 3719
[2] Tetrahedron, 2010, vol. 66, # 18, p. 3370 - 3377
[3] Patent: EP3269715, 2018, A1. Location in patent: Paragraph 0238; 0239
[4] European Journal of Medicinal Chemistry, 2017, vol. 132, p. 26 - 41
[5] European Journal of Medicinal Chemistry, 1981, vol. 16, # 3, p. 229 - 232
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Suppliers
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View Lastest Price from BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE manufacturers
- Product
- BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 78818-15-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 78818-15-2
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-09