ChemicalBook > CAS DataBase List > BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE

BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE

Product Name
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
CAS No.
78818-15-2
Chemical Name
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
Synonyms
BUTTPARK 32\04-69;4-CBZ-PIPERAZINONE;N-CBZ-PIPERAZINONE;4-Z-PIPERAZIN-2-ONE;1-Z-3-OXOPIPERAZINE;N'-Z-PIPERAZIN-2-ONE;1-CBZ-3-OXOPIPERAZINE;1-Z-3-oxopiperazine;N-CARBOXYBENZYLOXYPIPERAZINONE;1-Carbobenzoxy-3-oxopiperazine
CBNumber
CB0413217
Molecular Formula
C12H14N2O3
Formula Weight
234.25
MOL File
78818-15-2.mol
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BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Property

Melting point:
118-120°C
Boiling point:
459.8±45.0 °C(Predicted)
Density 
1.243±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
14.98±0.20(Predicted)
color 
White to Orange to Green
InChIKey
BAHFPJFBMJTOPU-UHFFFAOYSA-N
CAS DataBase Reference
78818-15-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
667641
Product name
1-Z-3-oxopiperazine
Purity
97%
Packaging
5g
Price
$254
Updated
2023/06/20
TCI Chemical
Product number
B4100
Product name
Benzyl 3-Oxopiperazine-1-carboxylate
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
B4100
Product name
Benzyl 3-Oxopiperazine-1-carboxylate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$183
Updated
2025/07/31
TRC
Product number
B521438
Product name
Benzyl 3-Oxopiperazine-1-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
263594
Product name
4-Benzyloxycarbonyl-2-piperazinone
Packaging
5g
Price
$656
Updated
2021/12/16
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BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Benzyl 3-oxopiperazine-1-carboxylate is a useful research reagent for organic synthesis and other chemical processes.

Synthesis

5625-67-2

501-53-1

78818-15-2

Step 2: Synthesis of benzyl 3-oxopiperazine-1-carboxylate Sodium carbonate (24.77 g, 233.73 mmol, 3.00 eq.) and piperazin-2-one (7.80 g, 77.91 mmol, 1.00 eq.) were dissolved in a solvent mixture of ethyl acetate (70.00 mL) and water (70.00 mL) at 0 °C. Subsequently, benzyl chloroformate (16.79 g, 93.49 mmol, 13.99 mL, 95% purity, 1.20 eq.) was slowly added. The reaction mixture was stirred at 30 °C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was extracted with ethyl acetate (80 mL x 3). The organic layers were combined, washed with saturated aqueous sodium chloride (80 mL x 3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by pulping (petroleum ether: ethyl acetate= 20:1,80mL) and filtered after stirring at 30°C for 15 min. The solid was dried under vacuum to obtain 4-Benzyloxycarbonyl-2-piperazinone (15.50 g, 66.17 mmol, 84.93% yield) as a white solid.

References

[1] Journal of Organic Chemistry, 1991, vol. 56, # 11, p. 3715 - 3719
[2] Tetrahedron, 2010, vol. 66, # 18, p. 3370 - 3377
[3] Patent: EP3269715, 2018, A1. Location in patent: Paragraph 0238; 0239
[4] European Journal of Medicinal Chemistry, 2017, vol. 132, p. 26 - 41
[5] European Journal of Medicinal Chemistry, 1981, vol. 16, # 3, p. 229 - 232

BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE Suppliers

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View Lastest Price from BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 78818-15-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE 78818-15-2
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-09

78818-15-2, BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATERelated Search:

4-BENZYLOXY-3-METHOXYBENZYL ALCOHOL 4-benzyl-3,5-dimethylbenzonitrile 4-N-BENZYL-2-HYDROXYMETHYLPIPERAZINE 2-Piperazinone 1-Cbz-4-Piperidone Ethyl N-piperazinecarboxylate BENZYL 2-(2-ETHOXY-2-OXOETHYL)-3-OXOPIPERAZINE-1-CARBOXYLATE BENZYL 1-PIPERAZINECARBOXYLATE METHYL PIPERAZINE-1-CARBOXYLATE BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE N-(HYDROXYMETHYL)PIPERAZINE 1-PIPERAZINECARBOXYLIC ACID

  • 3-OXOPIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER
  • 4-Z-PIPERAZIN-2-ONE
  • 4-BENZYLOXYCARBONYL-2-PIPERAZINONE
  • 4-BENZYLOXYCARBONYLPIPERAZIN-2-ONE
  • 1-Piperazinecarboxylicacid, 3-oxo-, phenylmethyl ester
  • 1-<I>Z</I>-3-oxopiperazine
  • N'-Z-PIPERAZIN-2-ONE
  • 1-Z-3-OXOPIPERAZINE
  • 4-CBZ-PIPERAZINONE
  • BUTTPARK 32\04-69
  • BENZYL 3-OXOTETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
  • BENZYL 3-OXOPIPERAZINE-1-CARBOXYLATE
  • Piperazin-2-one, N4-CBZ protected
  • 1-CBZ-3-OXOPIPERAZINE
  • N-CBZ-PIPERAZINONE
  • N-CARBOXYBENZYLOXYPIPERAZINONE
  • 3-Oxopiperazine-1-carboxylic acid benzyl ester, 4-Benzyloxycarbonyl-2-piperazinone
  • Benzyl 3-oxopiperazine-1-carboxylate, 4-[(Benzyloxy)carbonyl]piperazin-2-one
  • 4-Benzyloxycarbonyl-2-oxopiperazine
  • Benzyl 3-Oxopiperazine-1-carboxylate &gt
  • 1-Benzyloxycarbonyl-3-oxopiperazine
  • 1-Carbobenzoxy-3-oxopiperazine
  • 78818-15-2
  • C12H14N2O3
  • Piperazines
  • Heterocyclic Building Blocks
  • Building Blocks
  • pharmacetical
  • piperazines
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  • Heterocyclic Building Blocks