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IC 261

Product Name
IC 261
CAS No.
186611-52-9
Chemical Name
IC 261
Synonyms
CS-1551;IC261, >98%;SU-5607 IC 261;IC-261(SU-5607);IC261;SU5607;IC 261;SU 5607;IC261 - CAS 186611-52-9 - Calbiochem;3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one;(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one;IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase;1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607
CBNumber
CB2503626
Molecular Formula
C18H17NO4
Formula Weight
311.335
MOL File
186611-52-9.mol
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IC 261 Property

Melting point:
214 °C
storage temp. 
protect from light
solubility 
DMSO: 18 mg/mL soluble
form 
solid
color 
yellow
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Safety

WGK Germany 
3
HS Code 
2933.79.8500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I0658
Product name
IC 261
Purity
≥98% (HPLC)
Packaging
5mg
Price
$81.6
Updated
2024/03/01
Sigma-Aldrich
Product number
400090
Product name
IC261
Packaging
5mg
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
I1077
Product name
IC 261
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$132
Updated
2024/03/01
TCI Chemical
Product number
I1077
Product name
IC 261
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$460
Updated
2024/03/01
Cayman Chemical
Product number
17260
Product name
IC 261
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
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IC 261 Chemical Properties,Usage,Production

General Description

A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 μM) and CK1ε (IC50 = 0.6-1.4 μM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 μM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 μM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.

Biological Activity

ic261 is a novel inhibitor of ck1.the p53-targeted kinases casein kinase 1delta (ck1delta) and casein kinase 1epsilon (ck1epsilon) have been reported to be involved in regulating dna repair and chromosomal segregation.

Biochem/physiol Actions

Cell permeable: yes

in vitro

previoius study found that ic261 could trigger the mitotic checkpoint control. at low micromolar concentrations, ic261 inhibited cytokinesis leading to a transient mitotic arrest. cells with active p53 arrested in the postmitotic g1 phase by blockage of entry into the s phase. cells containing non-functional p53 had postmitotic replication developing an 8n dna content. the increase of dna content was accompanied by a high amount of micronucleated and apoptotic cells. immunfluorescence images also showed that ic261 could result in centrosome amplification causing multipolar mitosis at low concentrations [1].

in vivo

animal study indicated that intrathecal injection of ic261 (0.1-1 nmol) could dose-dependently decrease mechanical allodynia and thermal hyperalgesia that were induced by carrageenan or cfa. in addition, bath-application of ic261 (1 μm) showed only marginal effects on spontaneous excitatory postsynaptic currents recorded in the substantia gelatinosa neurons of control mice. however, ic261 could decrease the frequency of sepscs in both inflammatory pain models [2].

IC 50

16 μm

storage

Store at -20°C

References

1]. behrend l, et al. ic261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. oncogene. 2000 nov 9;19(47):5303-5313.
[2] kurihara t,et al. alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (ck1) inhibitors. mol pain.2014 mar 10;10:17.

IC 261 Preparation Products And Raw materials

Raw materials

Preparation Products

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IC 261 Suppliers

Americas 1 China 70 Europe 1 India 2 Japan 1 Switzerland 1 United Kingdom 2 United States 12 Global 90
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0
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View Lastest Price from IC 261 manufacturers

Career Henan Chemical Co
Product
IC 261 186611-52-9
Price
US $1.00/ASSAYS
Min. Order
100ASSAYS
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

186611-52-9, IC 261Related Search:

su5204 SU5208 SU 5214 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE VEGFR2 Kinase Inhibitor I SU 5205 NSC 247030

  • IC261, >98%
  • IC-261(SU-5607)
  • IC261 - CAS 186611-52-9 - Calbiochem
  • IC261;SU5607;IC 261;SU 5607
  • CS-1551
  • SU5607, 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
  • 1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607
  • SU-5607 IC 261
  • (E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one
  • 3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one
  • IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase
  • 186611-52-9
  • Inhibitors