4-Bromomethyl-2-cyanobiphenyl

Product Name: 4-Bromomethyl-2-cyanobiphenyl
CAS No.: 114772-54-2
Chemical Name: 4-Bromomethyl-2-cyanobiphenyl
Synonyms: Br-OTBN;4-Bromoethyl-2-cyanobiphenyl;Irbesartan BroMo Cyano IMpurity;Valsartan Impurity 7;OTBNBR;4&priMe;Bromocyanobiphenyl;Bromosartan biphenyl;Valsartan Impurity J;Valsartan impurity 10
CBNumber: CB2685168
Molecular Formula: C14H10BrN
Formula Weight: 272.14
MOL File: 114772-54-2.mol

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4-Bromomethyl-2-cyanobiphenyl Property

Melting point:: 125-128 °C (lit.)
Boiling point:: 413.2±38.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
vapor pressure: 0.1-0.2Pa at 20-25℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Insoluble in water
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
form: powder to crystal
color: White to Almost white
InChI: InChI=1S/C14H10BrN/c15-9-11-5-7-12(8-6-11)14-4-2-1-3-13(14)10-16/h1-8H,9H2
InChIKey: LFFIEVAMVPCZNA-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(CBr)C=C2)=CC=CC=C1C#N
LogP: 3.2
CAS DataBase Reference: 114772-54-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,N
Risk Statements: 20/21/22-36/37/38-50/53-43
Safety Statements: 26-36/37-36/37/39-61-60
RIDADR: 3439
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 535494
Product name: 4′-Bromomethyl-2-biphenylcarbonitrile
Purity: 97%
Packaging: 5g
Price: $43.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 535494
Product name: 4′-Bromomethyl-2-biphenylcarbonitrile
Purity: 97%
Packaging: 25g
Price: $138
Updated: 2024/03/01

TCI Chemical

Product number: B1806
Product name: 4'-Bromomethyl-2-cyanobiphenyl
Purity: >98.0%(GC)
Packaging: 5g
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: B1806
Product name: 4'-Bromomethyl-2-cyanobiphenyl
Purity: >98.0%(GC)
Packaging: 25g
Price: $109
Updated: 2024/03/01

Alfa Aesar

Product number: H55394
Product name: 4'-(Bromomethyl)biphenyl-2-carbonitrile, 98%
Packaging: 5g
Price: $52.65
Updated: 2024/03/01

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4-Bromomethyl-2-cyanobiphenyl Chemical Properties,Usage,Production

Description

4-Bromomethyl-2-cyanobiphenyl is an important pharmaceutical intermediate and organic synthetic material used in the preparation of drugs of the sartan class such as azilsartan ester and temisartan. It is also used in the synthesis of other pyrazolines and related derivatives. In addition, recently reported studies on the role of 4-Bromomethyl-2-cyanobiphenyl in the determination of potential genotoxic impurities in temesartan using ESI-MS/MS technique and thermodynamic studies in different solvents^[1-2].

Chemical Properties

4-Bromomethyl-2-cyanobiphenyl is Cream powder

Uses

4-Bromomethyl-2-cyanobiphenyl used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.

Synthesis

4-Bromomethyl-2-cyanobiphenyl is synthesised using 2-cyano-4-methylbiphenyl as a raw material by chemical reaction. The specific synthesis steps are as follows:
A method for preparing dibromohydantoin-based normal temperature bromosartan biphenyl. Dissolve 10g 2-cyano-4-methylbiphenyl in 30mL dichloromethane and put it into syringe A tube; add 9g dibromo Hydantoin was dissolved in 30 mL of dichloromethane and put into the syringe B tube. Install the two syringes A and B on the flow syringe pump and assemble them. Set the flow rate of the two tubes A and B to 1.5 mL/min. Turn on the constant temperature water bath device, heat to 50°C, keep the temperature, turn on 4000K LED light with 475nm light for 30 minutes, and turn on the flow reactor at the same time. After the reaction is completed, add 15g of sodium bisulfite to the receiving product to quench, separate the liquids, remove the solvent by rotary evaporation of the organic phase, add isopropyl ether to recrystallize, filter with suction, and place the filter cake in an oven to obtain a pure product. The product 4-Bromomethyl-2-cyanobiphenyl has a purity of 90% and a yield of 94%.

References

[1] MANIKANTH REDDY YARALA; Sowjanya G. Determination of Potential Genotoxic Impurities (Orthophenylene Diamine Dihydrochloride), 4'-Bromomethyl-2-Cyanobiphenyl, 4'(Dibromomethyl)[1,1'-Biphenyl]-2-Carbonitrile in Telmisartan by ESI-MS/MS.[J]. Journal of chromatographic science, 2023. DOI:10.1093/chromsci/bmab139.
[2] JINGXIANG YANG . Thermodynamics of 4’-bromomethyl-2-cyanobiphenyl in different solvents[J]. Journal of Chemical Thermodynamics, 2015. DOI:10.1016/j.jct.2014.12.002.

4-Bromomethyl-2-cyanobiphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromomethyl-2-cyanobiphenyl Suppliers

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View Lastest Price from 4-Bromomethyl-2-cyanobiphenyl manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Bromomethyl-2-cyanobiphenyl 114772-54-2
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-11-20

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Bromomethyl-2-cyanobiphenyl 114772-54-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100tons
Release date: 2023-09-08

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4'-bromomethyl-2-cyanobiphenyl 114772-54-2
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 50 ton
Release date: 2024-08-15

114772-54-2, 4-Bromomethyl-2-cyanobiphenylRelated Search:

FIREMASTER BP-6 4'-Methyl-2-cyanobiphenyl 2-Bromobiphenyl Decabromodiphenyl oxide Irbesartan Valsartan Losartan potassium 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Valsartan N1-Trityl R-IsoMer Valsartan D9 Valsartan Impurity 12 ethyl N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-N-pentanoyl-L-valinate Valsartan Desvaleryl Impurity Valsartan n-Propyl N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE Valsartan Impurity 1 Valsartan Related Compound A

2-CYANO-4'-BROMOMETHYLBIPHENYL

2-(4-BROMO-METHYLPHENYL) BENZONITRILE

OTBNBR

4-BroMoMethyl-2-cyanophenyl

bromoethylcyanobiphenyl

4-Bromomethyl-2'-Cyano Biphenyl 2-Cyano-4'-Bromomethyl Biphenyl

4-Bromomethyl-2'-cyanobiphene

Sartan Bromo biphenyl

4-Bromomethyl-2-cyanobiphenyl,98%

2-Cyano-4μ-bromomethylbiphenyl, 4μ-(Bromomethyl)-2-cyanobiphenyl

4'-Bromoethyl-2-cyanobiphenyl

4-Bromoethyl-2-cyanobiphenyl

2-Cyano-4'-bromomethyl Diphenyl

2'-Cyano-4-Bromomethyl

2-CYANO-4-BROMOMETHYLBIPHENY

4-BROMOMETHYL-2-CYANOBIPHENIL

2-(4-bromo-2-methylphenyl)benzonitrile

4-BroMoMethyl-2-cyanobiphenyl, 98% 5GR

4-(2-Cyanophenyl)benzyl BroMide

4'-Bromomethylbiphenyl-2-carbonitrile 2-Cyano-4'-bromomethylbiphenyl

Br-OTBN

Irbesartan BroMo Cyano IMpurity

4'-(Bromomethyl)-2-cyanobiphenyl, 4-(2-Cyanophenyl)benzyl bromide, 2-[4-(Bromomethyl)phenyl]benzonitrile

4&priMe

-BroMoMethyl-2-biphenylcarbonitrile

4'-Bromomethyl-2-biphenylcarbonitrile 97%

Valsartan Impurity 7

4'-BROMOMETHYLBIPHENYL-2-CARBONITRILE

4'-BROMOMETHYL-2-BIPHENYLCARBONITRILE

4'-BROMOMETHYL-2-CYANOBIPHENYL

[1,1'-BIPHENYL]-2-CARBONITRILE, 4'-(BROMOMETHYL)-

2'-CYANO-4-BROMOMETHYL BIPHENYL

2-Cyano-4’-Bromomethylbiphenyl (BrOTBN)

4'-Bromomethyl-2-cyanobiphenyl ,99%

4′-Bromomethyl-2-biphenylcarbonitrile,2-Cyano-4′-bromomethylbiphenyl, 4′-(Bromomethyl)-2-cyanobiphenyl

Valsartan impurity 10

Telmisartan Bromo Nitrile Impurity

2-cyano-4'-Bromomethyl Biphenyl (Bromo OTBN)

Irbesartan Bromo Nitrile Impurity

Bromocyanobiphenyl

Bromosartan biphenyl

4'-Bromomethyl-2-cyanobiphenyl &gt

2'- cyano-4- bromomethylbenzene

4-BROMOMETHYL-2-CYANOBIPHENYL [Br-OTBN]

4-Bromomethyl-2-cyanobiphenyl ISO 9001：2015 REACH

Irbesartan Bromo Cyano Impurity (Telmisartan Bromo Nitrile Impurity)

4-Bromomethyl-2-Cyanobiphenyl (BROMO-OTBN)

Br-OTBN(2-Cyano-4'-bromomethybiphenyl)

4'-(bromomethyl)biphenyl-2-carbonitrile (Bromo OTBN)

4-bromomethyl-1,1 biphenyl-2-carbonitrileQ: What is 4-bromomethyl-1,1 biphenyl-2-carbonitrile Q: What is the CAS Number of 4-bromomethyl-1,1 biphenyl-2-carbonitrile Q: What is the storage condition of 4-bromomethyl-1,1 biphenyl-2-carbonitrile Q: What are the applications of 4-bromomethyl-1,1 biphenyl-2-carbonitrile

Valsartan Impurity J

BR-OTBN4'-Bromomethyl-2-cyanobiphenyl

4-Bromomethyl-2-cyanobiphenyl OTBN

4'-Bromomethyl-2-biphenylcarbonitrile, 98%

Irbesartan Bromo Nitrile Impurity 4'-(Bromomethyl)biphenyl-2-carbonitrile

4-(Bromo Methyl) Biphenyl-2-Carbonitrate) Intermediate of Valsartan

4'-Bromomethyl-2-cyanobiphenyl

4'-(Bromomethyl)-[1,1'-biphenyl]-2-carbonitrile