DODAP

Product Name: DODAP
CAS No.: 127512-29-2
Chemical Name: DODAP
Synonyms: DODAP;18:1 DAP;DODAP (18:1);1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE;1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE;3-(dimethylamino)propane-1,2-diyl dioleate;(Z)-3-(Dimethylamino)propane-1,2-diyl dioleate;1,2-dioleoyl-3-dimethylammonium-propane (DODAP);1,2-dioleoxy-3- (dimethylamino) propane (DODAP);1,2-dioleoyloxy-3- (dimethylamino) propane (DODAP)
CBNumber: CB2703992
Molecular Formula: C41H77NO4
Formula Weight: 648.05
MOL File: 127512-29-2.mol

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DODAP Property

Boiling point:: 670.1±55.0 °C(Predicted)
Density: 0.916±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Oil
pka: 8.02±0.28(Predicted)
color: Colourless to Light Yellow
Stability:: Light Sensitive; Hydroscopic; Store at -15 to -25°C
InChIKey: NYDLOCKCVISJKK-WRBBJXAJSA-N
SMILES: C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D6266
Product name: 3-(Dimethylamino)propane-1,2-diyl Dioleate
Packaging: 50MG
Price: $194
Updated: 2025/07/31

TCI Chemical

Product number: D6266
Product name: 3-(Dimethylamino)propane-1,2-diyl Dioleate
Packaging: 200MG
Price: $483
Updated: 2025/07/31

Cayman Chemical

Product number: 25726
Product name: 1,2-Dioleoyl-3-dimethylammonium-propane
Purity: ≥98%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 25726
Product name: 1,2-Dioleoyl-3-dimethylammonium-propane
Purity: ≥98%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 25726
Product name: 1,2-Dioleoyl-3-dimethylammonium-propane
Purity: ≥98%
Packaging: 50mg
Price: $190
Updated: 2024/03/01

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DODAP Chemical Properties,Usage,Production

Description

DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).

Chemical Properties

Light Yellow Oil

Uses

DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation[1][2][3][4][5].

in vivo

In vitro potency of DODAP (100 μg/mL, i.v., i.m., 4h) strongly predicts in vivo potency for intramuscular administration but not for intravascular administration in female Balb/c mice^[1].

Animal Model:	female Balb/c mice^[1]
Dosage:	100 μg/mL
Administration:	Intravenous injection (i.v.), Intramuscular injection (i.m.),4 h
Result:	Treatment resulted that a less negatively charged DODAP was more efficient in vitro and in vivo intramuscular injection, while for Intravenous injection administration, a more negative DODAP that was passively targeted through Apo-E absorption was more efficient for hepatocyte targeting.

References

[1] Carrasco MJ, et al. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Commun Biol. 2021 Aug 11;4(1):956. DOI:10.1038/s42003-021-02441-2
[2] Dabbas S, et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium. 2008;15(4):189-201. DOI:10.1080/10623320802228583
[3] Hamzah J, et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol. 2009;183(2):1091-1098. DOI:10.4049/jimmunol.0900736
[4] Liu Q, et al. Biotinylated cyclen-contained cationic lipids as non-viral gene delivery vectors. Chem Biol Drug Des. 2013;82(4):376-383. DOI:10.1111/cbdd.12159
[5] Mendon?a LS, et al. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment. Bioconjug Chem. 2010 Jan;21(1):157-68. DOI:10.1021/bc9004365

DODAP Preparation Products And Raw materials

Raw materials

Preparation Products

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DODAP Suppliers

Canada 1 CHINA 88 Germany 1 India 1 United Kingdom 1 United States 11 Global 103

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 307
Advantage: 58

Shochem (Shanghai) Co.,Ltd

Tel: 13611745246 13816874662
Email: sales@shochem.com
Country: China
ProdList: 534
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Yichang Zhongyitai Trading Co., Ltd.

Tel: 0717-6449896 13886658719
Fax: 0717-6558598
Email: root@zhongyitai.com
Country: China
ProdList: 1978
Advantage: 58

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View Lastest Price from DODAP manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: DODAP 127512-29-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: DODAP 127512-29-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-07-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: DODAP 127512-29-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

127512-29-2, DODAPRelated Search:

1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHO-L-SERINE SODIUM SALT PEG2000-C-DMG 1,2-dipalMitoyl-sn-glycero-3-phosphoethanolaMine-N-[3-(2-pyridyldithio)propionate] (sodiuM salt) 1-STERAOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHO-L-SERINE (MONOSODIUM SALT) Hexadecanoic acid, 1,1'-[(1S)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester 1-STEAROYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE DMG-PEG 2000 1-OCTADECANOYL-2-[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE DODMA DODAP N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE DOTAP MESYLATE

18:1 DAP

9-Octadecenoic acid(9Z)-1,1'-[1-[(dimethylamino)methyl]-1,2-ethanediyl] ester

1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE

1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE

DODAP

(+/-)-N,N-dimethyl-N-[2,3-bis(9-(Z)-octadecanoyloxy)propyl]amine

1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

(Z)-3-(Dimethylamino)propane-1,2-diyl dioleate

DODAP (18:1)

1,2-dioleoyloxy-3- (dimethylamino) propane (DODAP)

3-(dimethylamino)propane-1,2-diyl dioleate

1,2-dioleoxy-3- (dimethylamino) propane (DODAP)

127512-29-2

C41H77NO4

Mixed Fatty Acids

Fatty Acid Derivatives & Lipids

Glycerols

Glycerols, Fatty Acid Derivatives & Lipids