DODAP
- Product Name
- DODAP
- CAS No.
- 127512-29-2
- Chemical Name
- DODAP
- Synonyms
- DODAP;18:1 DAP;DODAP (18:1);1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE;1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE;3-(dimethylamino)propane-1,2-diyl dioleate;(Z)-3-(Dimethylamino)propane-1,2-diyl dioleate;1,2-dioleoyl-3-dimethylammonium-propane (DODAP);1,2-dioleoxy-3- (dimethylamino) propane (DODAP);1,2-dioleoyloxy-3- (dimethylamino) propane (DODAP)
- CBNumber
- CB2703992
- Molecular Formula
- C41H77NO4
- Formula Weight
- 648.05
- MOL File
- 127512-29-2.mol
DODAP Property
- Boiling point:
- 670.1±55.0 °C(Predicted)
- Density
- 0.916±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- 8.02±0.28(Predicted)
- color
- Colourless to Light Yellow
- Stability:
- Light Sensitive; Hydroscopic; Store at -15 to -25°C
- InChIKey
- NYDLOCKCVISJKK-WRBBJXAJSA-N
- SMILES
- C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D6266
- Product name
- 3-(Dimethylamino)propane-1,2-diyl Dioleate
- Packaging
- 50MG
- Price
- $194
- Updated
- 2025/07/31
- Product number
- D6266
- Product name
- 3-(Dimethylamino)propane-1,2-diyl Dioleate
- Packaging
- 200MG
- Price
- $483
- Updated
- 2025/07/31
- Product number
- 25726
- Product name
- 1,2-Dioleoyl-3-dimethylammonium-propane
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 25726
- Product name
- 1,2-Dioleoyl-3-dimethylammonium-propane
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 25726
- Product name
- 1,2-Dioleoyl-3-dimethylammonium-propane
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $190
- Updated
- 2024/03/01
DODAP Chemical Properties,Usage,Production
Description
DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).
Chemical Properties
Light Yellow Oil
Uses
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation[1][2][3][4][5].
in vivo
In vitro potency of DODAP (100 μg/mL, i.v., i.m., 4h) strongly predicts in vivo potency for intramuscular administration but not for intravascular administration in female Balb/c mice[1].
| Animal Model: | female Balb/c mice[1] |
| Dosage: | 100 μg/mL |
| Administration: | Intravenous injection (i.v.), Intramuscular injection (i.m.),4 h |
| Result: | Treatment resulted that a less negatively charged DODAP was more efficient in vitro and in vivo intramuscular injection, while for Intravenous injection administration, a more negative DODAP that was passively targeted through Apo-E absorption was more efficient for hepatocyte targeting. |
References
[1] Carrasco MJ, et al. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Commun Biol. 2021 Aug 11;4(1):956. DOI:10.1038/s42003-021-02441-2
[2] Dabbas S, et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium. 2008;15(4):189-201. DOI:10.1080/10623320802228583
[3] Hamzah J, et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol. 2009;183(2):1091-1098. DOI:10.4049/jimmunol.0900736
[4] Liu Q, et al. Biotinylated cyclen-contained cationic lipids as non-viral gene delivery vectors. Chem Biol Drug Des. 2013;82(4):376-383. DOI:10.1111/cbdd.12159
[5] Mendon?a LS, et al. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment. Bioconjug Chem. 2010 Jan;21(1):157-68. DOI:10.1021/bc9004365
DODAP Preparation Products And Raw materials
Raw materials
Preparation Products
DODAP Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from DODAP manufacturers
- Product
- DODAP 127512-29-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- DODAP 127512-29-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle , 10g/bottle, 100g/bottle
- Release date
- 2024-07-26
- Product
- DODAP 127512-29-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10