5-Dibenzosuberenone

合成方法

Product Name: 5-Dibenzosuberenone
CAS No.: 2222-33-5
Chemical Name: 5-Dibenzosuberenone
Synonyms: DIBENZOSUBERENONE;5H-DIBENZO[A,D]CYCLOHEPTEN-5-ONE;Dibenzo[a,d]cyclohepten-5-one;NSC 86151;Dibenzosberenone;5-DIBENZOSUBERENONE;DIBENZOSUBERENONE-5;Dibenzosuberenone>Dibenzosuberenone,97%;2,3,6,7-Dibenzotropone
CBNumber: CB2706074
Molecular Formula: C15H10O
Formula Weight: 206.24
MOL File: 2222-33-5.mol

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5-Dibenzosuberenone Property

Melting point:: 87-88 °C (lit.)
Boiling point:: 210 °C / 3mmHg
Density: 1.0701 (rough estimate)
vapor pressure: 0.006Pa at 25℃
refractive index: 1.6324 (estimate)
Flash point:: >110℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Crystalline Powder
Specific Gravity: 1.156
color: White to pale yellow or beige
Water Solubility: Soluble in chloroform, ethyl acetate. Insoluble in water.
BRN: 743171
InChIKey: SNVTZAIYUGUKNI-UHFFFAOYSA-N
LogP: 3.508 at 25℃
CAS DataBase Reference: 2222-33-5(CAS DataBase Reference)
NIST Chemistry Reference: 5H-Dibenzo[a,d]cyclohepten-5-one(2222-33-5)
EPA Substance Registry System: 5H-Dibenzo[a,d]cyclohepten-5-one (2222-33-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
RIDADR: 3077
WGK Germany: 3
RTECS: HP1147500
Hazard Note: Irritant
TSCA: Yes
HazardClass: 9
PackingGroup: III
HS Code: 29143990
Toxicity: mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02244,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D31737
Product name: 5-Dibenzosuberenone
Purity: 97%
Packaging: 25g
Price: $185
Updated: 2024/03/01

Sigma-Aldrich

Product number: D31737
Product name: 5-Dibenzosuberenone
Purity: 97%
Packaging: 100g
Price: $191
Updated: 2024/03/01

TCI Chemical

Product number: D1791
Product name: Dibenzosuberenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $67
Updated: 2024/03/01

TRC

Product number: D417335
Product name: 5-Dibenzosuberenone
Packaging: 2g
Price: $75
Updated: 2021/12/16

TRC

Product number: D417335
Product name: 5-Dibenzosuberenone
Packaging: 25g
Price: $155
Updated: 2021/12/16

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5-Dibenzosuberenone Chemical Properties,Usage,Production

合成方法

方法1：以二苯并[a,d]环庚-5-酮为起始物料，在CCl4中经溴素溴代回流反应18h，随后加入三乙胺再继续回流16h后经后处理制得目标产品。该方法用的毒性较大的原料，且制备反应周期也较长。方法2：以反式二溴代物为底物，在氩气保护及α-硒代噻吩、四甲基乙二胺作用下，经Schlenk管装置在光辐射下反应制得目标产物。该方法目标产品的制备在毫克级，并且需要柱层析提纯，难于量产。方法3：以3-(2-苯甲酰基苯基)丙烯酸为起始物料，在银系催化剂及氧化剂的作用下分子内脱羧偶联制得目标产品5-二苯并环庚烯酮。

Chemical Properties

5-Dibenzosuberenone is white to pale yellow or beige crystalline powder

Uses

5-Dibenzosuberenone Can be used in the synthesis of a series of potent antidepressants.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 8, p. 886, 1965 DOI: 10.1021/jm00330a044

5-Dibenzosuberenone Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide Ethanol 2,2'-Azobis(2-methylpropionitrile) N,N-Dimethylformamide Sodium sulfate Carbon tetrachloride 1,5-Diazabicyclo[4.3.0]non-5-ene Benzene Ethyl acetate Hydrochloric acid Dichloromethane Dibenzosuberone Pyridine PETROLEUM ETHER

Preparation Products

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5-Dibenzosuberenone Suppliers

Americas 1 Belgium 2 Canada 1 China 229 Europe 4 France 1 Germany 7 India 39 Italy 1 Japan 3 Singapore 1 Slovakia 1 South Korea 2 Switzerland 4 United Kingdom 13 United States 37 Global 346

Shanghai Witofly Chemical Co. ,Ltd.

Tel: 021-5063062 15300832537
Email: sales@witofly.com
Country: China
ProdList: 1603
Advantage: 55

Shanghai Hao Yun Chemical Science Co.,Ltd.

Tel: 021-68367562 15002147577;
Fax: 021-68369562
Email: sales@haoyunchem.com
Country: China
ProdList: 430
Advantage: 55

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.

Tel: 0513-82104991 18912868361
Fax: QQ1907456386
Email: sales2@btcpharm.com
Country: China
ProdList: 1329
Advantage: 58

Jiangsu Jingye Pharmaceutical

Tel: 0519-82765761 18001496617
Email: 2807841045@qq.com
Country: China
ProdList: 108
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5902
Advantage: 65

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

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View Lastest Price from 5-Dibenzosuberenone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Dibenzosuberenone 2222-33-5
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-19

Hebei Weibang Biotechnology Co., Ltd

Product: 5-Dibenzosuberenone 2222-33-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-11-25

Anhui Ruihan Technology Co., Ltd

Product: 5-Dibenzosuberenone 2222-33-5
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-09-11

2222-33-5, 5-DibenzosuberenoneRelated Search:

Oxybenzone CYCLOBENZAPRINE HCL 2-Phenylacetophenone Benzophenone hydrazone Benzophenone DIETHYLPROPION TROPONE CYCLOHEPTENE Cycloheptatriene Dibenzosuberone DIBENZOSUBERYL CHLORIDE CIS-STILBENE 2-METHYLSTYRENE 5H-dibenzo[a,d]cycloheptene 1-ETHYL-2-VINYL-BENZENE 5-Dibenzosuberenone 2,3:6,7-DIBENZOSUBERENONE CYPROHEPTADINE HYDROCHLORIDE IMP. B (EP): 5H-DIBENZO[A,D]CYCLOHEPTEN-5-ONE (DIBENZOSUBERENONE)

Cyproheptadine Impurity B

Cyproheptadine impurity B (5h-dibenzo A, D cycloheptene-5-one)

5H-DIBENZO[A,D]CYCLOHEPTEN-5-ONE

5H-DIBENZO(A,D)CYCLOHEPTENE-5-OL

5-DIBENZOSUBERENONE

Dibenzosuberenone,97%

Dibenzo[a,d]cyclohepten-5-one

NSC 86151

Cyclobenzaprine Dibenzosuberenone IMpurity

Cyproheptadine IMpurity B (Dibenzosuberenone)

5-Dibenzosuberenone, 98%+

5-Dibenzosuberenone 97%

dibenzo[1,2-a:1',2'-e][7]annulen-11-one

5-Dibenzosuberenone≥ 99% (GC)

5H-Dibenzo[α,δ]cyclohepten-5-one

DIBENZOSUBERENONE

DIBENZOSUBERENONE-5

DIBENZO[A,D]-CYCLOHEPTENE-5-ONE

DIBENZO[A,B] CYCLOHEPTEN-5-ONE

2,3,6,7-Dibenzotropone

2,3:6,7-Dibenzosuberen-4-on-1

2,3:6,7-Dibenzotropone

5H-Dibenzo[,d]cyclohepten-5-one

5H-Dibenzo[a,d]cycloheptenone

Dibenzo[,d]cycloheptatrien-5-one

H-Dibenzo(a,d)cyclohepten-5-one

5H-dibenzo[a,d][7]annulen-5-one

dibenzo[b,f]cyclohepten-1-one

5H-DIBENZO[A,D]CYCLOHEPTENE-5-ONE

Dibenzosberenone

Cyproheptad impurity B (non-specific state)

5-dibenzocycloheptenone

5H-Dibenzo[a,d]cyclohepten-5-one (D

Dibenzosuberenone&gt

5H-Dibenzo[a,d][7]annulen-5-one,>98%

dibenzo[1,2-a:1',2'-e][7]annulen-1one

ibenzo[1,2-a:1',2'-e][7]annulen-11-one

Dibenzo[b,f]cyclohepten-1-on

5-Dibenzosuberenone (Polpharma customer)

Cyproheptadine Impurity 6

Cyproheptadine Impurity 6 (Dibenzosuberenone)

dibenzo[1,2-a:1',2'-e][7]annulen-11-one

2222-33-5

Organic Building Blocks

Ketones

Building Blocks

C15 to C38

Carbonyl Compounds

Others chemical reagents

Aromatics

Intermediates

API intermediates

intermediate of cyclobenzaprine, cyproheptadine, d

Pharmaceutical Intermediates