Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate
- Product Name
- Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate
- CAS No.
- 46193-76-4
- Chemical Name
- Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate
- Synonyms
- 5-(Ethoxycarbonyl)-4H-thieno[3,2-b]pyrrole;Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate;ETHYL 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, ethyl ester
- CBNumber
- CB2706605
- Molecular Formula
- C9H9NO2S
- Formula Weight
- 195.24
- MOL File
- 46193-76-4.mol
Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate Property
- Melting point:
- 131-132°C
- Boiling point:
- 345.7±22.0 °C(Predicted)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 14.65±0.30(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C9H9NO2S/c1-2-12-9(11)7-5-8-6(10-7)3-4-13-8/h3-5,10H,2H2,1H3
- InChIKey
- BLUDZFMRKHHPGZ-UHFFFAOYSA-N
- SMILES
- N1C(C(OCC)=O)=CC2SC=CC1=2
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E945510
- Product name
- Ethyl4h-thieno[3,2-b]pyrrole-5-carboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 8H23-1-20
- Product name
- Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
- Packaging
- 500mg
- Price
- $253
- Updated
- 2021/12/16
- Product number
- 045127
- Product name
- Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- 045127
- Product name
- Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 8H23-1-20
- Product name
- Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
- Packaging
- 1g
- Price
- $336
- Updated
- 2021/12/16
Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
98-03-3
637-81-0
46193-76-4
GENERAL METHOD: Sodium ethoxide (8.17 g, 120 mmol, 20 wt% ethanol solution) was slowly added dropwise to an anhydrous ethanol (50 mL) mixture of 2-thiophenecarboxaldehyde (2.8 mL, 30 mmol) and ethyl azidoacetate (15.4 g, 120 mmol) at -10 °C. After dropwise addition, the reaction mixture was stirred at room temperature for 4 hours. Subsequently, the reaction was quenched by addition of excess saturated aqueous ammonium chloride solution. The mixture was extracted with ethyl acetate (2 x 80 mL), and the organic layers were combined, washed with saturated saline (2 x 60 mL) and dried over anhydrous sodium sulfate. After removing the solvent by evaporation under reduced pressure, the residue was dissolved in toluene (30 mL) and heated to reflux for 1 hour. After completion of the reaction, it was cooled to room temperature and the solvent was removed by evaporation. The residue was purified by column chromatography (eluent: n-hexane/dichloromethane=2:1) to afford ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate (4a) as a white solid (2.93 g, 50% yield). The product was characterized by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3) with the following data: 1H NMR δ 9.26 (br s, 1H), 7.32 (d, J = 5.2 Hz, 1H), 7.14 (d, J = 0.8 Hz, 1H), 6.96 (dd, J = 5.2, 0.8 Hz, 1H ), 4.38 (q, J = 7.6 Hz, 2H), 1.39 (t, J = 7.6 Hz, 3H); 13C NMR δ 161.7, 141.3, 129.4, 127.1, 124.8, 111.1, 107.5, 60.7, 14.5.
References
[1] Tetrahedron, 2012, vol. 68, # 47, p. 9795 - 9801,7
[2] Patent: US2004/48878, 2004, A1. Location in patent: Page/Page column 10-11
Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate manufacturers
- Product
- Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate 46193-76-4
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08