ChemicalBook > CAS DataBase List > 2-Methyl-4-methoxybenzenamine

2-Methyl-4-methoxybenzenamine

Product Name: 2-Methyl-4-methoxybenzenamine
CAS No.: 102-50-1
Chemical Name: 2-Methyl-4-methoxybenzenamine
Synonyms: 4-METHOXY-2-METHYLANILINE;Benzenamine, 4-methoxy-2-methyl-;2-Methoxy-3-methylaniline;4-Methoxy-2-methylbenzenamine;AKOS 91136;NCI-C02993;M-CRESIDINE;N-cresidine;meta-cresidine;2-methyl-p-anisidin
CBNumber: CB2712327
Molecular Formula: C8H11NO
Formula Weight: 137.18
MOL File: 102-50-1.mol

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2-Methyl-4-methoxybenzenamine Property

Melting point:: 13-14 °C(lit.)
Boiling point:: 248-249 °C(lit.)
Density: 1.065 g/mL at 25 °C(lit.)
refractive index: n20/D 1.565(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO, Methanol (Slightly)
form: Oil
pka: 5.05±0.10(Predicted)
color: Light Brown to Very Dark Red
Water Solubility: insoluble, <0.1 g/100 mL at 21.5 ºC
BRN: 774727
Stability:: Stable. May be light or air-sensitive. Combustible. Incompatible with acids, strong oxidizing agents.
InChIKey: CDGNLUSBENXDGG-UHFFFAOYSA-N
CAS DataBase Reference: 102-50-1(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 4-methoxy-2-methyl-(102-50-1)
IARC: 3 (Vol. 27, Sup 7) 1987
EPA Substance Registry System: m-Cresidine (102-50-1)

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Safety

Hazard Codes: Xi,Xn,T
Risk Statements: 36/37/38-40-45
Safety Statements: 26-36/37/39-53-45
RIDADR: 2810
WGK Germany: 3
RTECS: BZ6730000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29222990
Hazardous Substances Data: 102-50-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M15001
Product name: 4-Methoxy-2-methylaniline
Purity: 98%
Packaging: 5g
Price: $79.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: M15001
Product name: 4-Methoxy-2-methylaniline
Purity: 98%
Packaging: 25g
Price: $108
Updated: 2023/06/20

TCI Chemical

Product number: M1474
Product name: 4-Methoxy-2-methylaniline
Purity: >99.0%(GC)(T)
Packaging: 25g
Price: $100
Updated: 2025/07/31

TCI Chemical

Product number: M1474
Product name: 4-Methoxy-2-methylaniline
Purity: >99.0%(GC)(T)
Packaging: 500g
Price: $892
Updated: 2025/07/31

TRC

Product number: M263620
Product name: 4-Methoxy-2-methylaniline
Packaging: 25g
Price: $185
Updated: 2021/12/16

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2-Methyl-4-methoxybenzenamine Chemical Properties,Usage,Production

Chemical Properties

brick red crystals or liquid

Uses

4-Methoxy-2-methylaniline is a reagent used in organic synthesis of more complex compounds that have a more specific function. For example, enzyme inhibitors.

Definition

ChEBI: Meta-Cresidine is a member of methoxybenzenes.

General Description

Crystals or brick red liquid.

Air & Water Reactions

Sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

2-Methyl-4-methoxybenzenamine neutralizes acids in weakly exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .

Health Hazard

ACUTE/CHRONIC HAZARDS: 2-Methyl-4-methoxybenzenamine is a local irritant. When heated to decomposition it emits toxic fumes of NOx. 2-Methyl-4-methoxybenzenamine is an experimental animal carcinogen.

Fire Hazard

2-Methyl-4-methoxybenzenamine is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

5367-32-8

102-50-1

GENERAL PROCEDURE: 3-methyl-4-nitroanisole (1.0 mmol), B2(OH)4 (5.0 eq., 5.0 mmol) and H2O (3.0 mL) were added to a 10 mL reaction tube. The reaction mixture was stirred at 80 °C for 8 hours. After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 20 mL). The organic phases were combined, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-methyl-4-methoxyaniline.

References

[1] Analytical Chemistry, 1992, vol. 64, # 8, p. 837 - 842
[2] ChemCatChem, 2017, vol. 9, # 16, p. 3236 - 3244
[3] Synlett, 2018, vol. 29, # 13, p. 1765 - 1768
[4] Tetrahedron, 2017, vol. 73, # 27-28, p. 3898 - 3904
[5] Helvetica Chimica Acta, 1924, vol. 7, p. 698

2-Methyl-4-methoxybenzenamine Preparation Products And Raw materials

Raw materials

3-Methyl-4-nitrophenol Hydrazinium hydroxide solution Sodium Palladium Sodium Methoxide Hydrochloric acid Sodium bicarbonate Methanol Iron Dimethyl sulfate

Preparation Products

NAPHTHOL AS-LT 2-Hydroxy-N-(4-methoxy-2-methylphenyl)-11H-benzo[a]carbazole-3-carboxamide

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View Lastest Price from 2-Methyl-4-methoxybenzenamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Methyl-4-methoxybenzenamine 102-50-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Methyl-4-methoxybenzenamine 102-50-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Methyl-4-methoxybenzenamine 102-50-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

102-50-1, 2-Methyl-4-methoxybenzenamineRelated Search:

6-NITROPIPERONYL ALCOHOL 2-Methyl-4-methoxybenzenamine 6-Nitroveratraldehyde 4-METHOXY-2-METHYLPHENYL ISOCYANATE ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone 2,3-DIMETHYL-4-NITROANISOLE Methyl 2-amino-3,4,5-trimethoxybenzoate 4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL BRUCINE SULFATE 6-NITROPIPERONAL Methyl 4,5-dimethoxy-2-nitrobenzoate Methyl 2-amino-4,5-dimethoxybenzoate 2-Amino-5-methoxybenzoic acid Methyl 2-nitro-3,4,5-trimethoxybenzoate 2-Amino-4,5-dimethoxybenzoic acid 3-Methyl-4-nitroanisole 2-Methoxy-5-methylaniline

AKOS 91136

6-AMINO-3-METHOXYTOLUENE

4-METHOXY-2-METHYLANILINE

4-METHOXY-O-TOLUIDINE

3-METHYL-4-AMINOANISOLE

2-METHYL-P-ANISIDINE

2-METHYL-4-METHOXYBENZENAMINE

1-AMINO-4-METHOXY-2-METHYLBENZENE

M-CRESIDINE

1-Amino-4-methoxy-2-methylbenzene m-Cresidine 4-Methoxy-o-toluidine

2-Amino-5-methoxytoluene, 4-Amino-3-methylanisole, 2-Methyl-p-anisidine, 4-Methoxy-o-toluidine

4-Methoxy-2-Methylaniline, 98% 5GR

4-AMino-3-Methylanisole[4-Methoxy-2-Methylaniline]

4-Methoxy-2-Methylaniline , 98.0%(GC&T

4-Methoxy-2-methyl-phenylamine

Benzenamine, 4-methoxy-2-methyl-

4-Amino-3-methylanisole

2-Methyl-4-methoxybenzemine

4-Methoxy-2-methylaniline (m-Cresidine)

2-Amino-5-Methoxytoluene

4-METHOXY-2-METHYLANILINE 98.5%

2-Amino-5-methoxytoluene, 4-Amino-3-methylanisole

2-Methyl-p-anisidine, m-Cresidine

2-methyl-p-anisidin

4-methoxy-2-methyl-benzenamin

4-Methoxy-2-methylbenzenamine

NCI-C02993

p-Anisidine, 2-methyl-

2-Methyl-4-Methoxybenzenamine 2-Amino-5-Methoxytoluene

5-methoxy-2-methylbenzenamine

meta-cresidine

2-Methyl-p-anisidine(NH2=1)

N-[1,2-Dihydroxy-2-(prop-2-enoylamino)ethyl]prop-2-enamide

4-Methoxy-2-methylaniline ,98%

N-cresidine

2-Methoxy-3-methylaniline

2-Methyl-4-emthoxyaniline

4-Methoxy-2-methylaniline&gt

2-Methyl-4-methoxybenzenamine ISO 9001：2015 REACH

2-Methyl-4-(methyloxy)aniline

4-Methoxy-2-methylaniline, ≥ 98.0%

4-Amino-m-metylanisole

102-50-1

CH3OC6H3CH3NH2

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