METHYL PHENYL CARBONATE

METHYL PHENYL CARBONATE Property

Melting point:

147-151 °C

Boiling point:

210-213℃

Density 

1.5214g/ml

refractive index 

1.4985

storage temp. 

Inert atmosphere,Room Temperature

Appearance

Colorless to light yellow Liquid

Stability:

Stable. Incompatible with strong oxidizing agents.

Safety

Safety Statements 

22-24/25

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

METHYL PHENYL CARBONATE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Synthesis

GENERAL METHODS: To a solution of methanol (0.7 mmol) and AlCl3 (0.7 mmol) in toluene (10 mL) was added compound 3 (CAS:1202680-24-7, 0.7 mmol). The progress of the reaction was monitored by thin layer chromatography (TLC) and the mixture was stirred at room temperature until the compound 3 was completely consumed. Upon completion of the reaction, 10% NaOH aqueous solution (50 mL) and dichloromethane (30 mL) were added to the reaction mixture under stirring for extraction. The organic layer was separated and washed with distilled water (50 mL) and subsequently dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by passing through an open silica gel column (2.5 x 4 cm) using hexane/ethyl acetate (3:1, v/v) as eluent. Compounds 5 and 6 were eluted first, followed by ethyl acetate. Finally, 4,5-dichloropyridazin-3(2H)-one (1) was eluted. The column chromatography fractions containing the pure compounds were combined and the solvents were evaporated under reduced pressure to afford the target product, methyl phenyl carbonate.4,5-Dichloropyridazin-3(2H)-one was obtained in quantitative yield and was reusable.

References

[1] Bulletin of the Korean Chemical Society, 2014, vol. 35, # 9, p. 2758 - 2764
[2] Synlett, 2016, vol. 27, # 10, p. 1577 - 1581