Description References
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Lomefloxacin

Description References
Product Name
Lomefloxacin
CAS No.
98079-51-7
Chemical Name
Lomefloxacin
Synonyms
Lomefloxacine;LFLX;dm-10;Clfimono;SC 47111A;Lomel9act;LOMEFLOXACIN;LEMOFLOXACIN;LoMenfloxacin;Lomefloxacino
CBNumber
CB2723615
Molecular Formula
C17H19F2N3O3
Formula Weight
351.35
MOL File
98079-51-7.mol
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Lomefloxacin Property

Melting point:
239-240 C
Boiling point:
542.7±50.0 °C(Predicted)
Density 
1.342±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka
-0.25±0.20(Predicted)
form 
Solid
color 
Pale Yellow to Light Yellow
CAS DataBase Reference
98079-51-7(CAS DataBase Reference)
EPA Substance Registry System
3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (98079-51-7)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
VB1997500
HS Code 
29419000
Toxicity
LD50 in mice (mg/kg): 245.6 i.v.; >4000 orally (Itoh)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
L469418
Product name
Lomefloxacin
Packaging
100mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
J98130
Product name
Lomefloxacin
Packaging
1g
Price
$78
Updated
2021/12/16
AK Scientific
Product number
J98130
Product name
Lomefloxacin
Packaging
5g
Price
$239
Updated
2021/12/16
AvaChem
Product number
3890
Product name
Lomefloxacin
Packaging
100mg
Price
$179
Updated
2021/12/16
Crysdot
Product number
CD31000032
Product name
Lomefloxacin
Purity
98+%
Packaging
100mg
Price
$55
Updated
2021/12/16
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Lomefloxacin Chemical Properties,Usage,Production

Description

Lomefloxacin is a kind of fluoroquinolone antibiotics used for the treatment of bacterial infections such as bronchitis and urinary tract infection. It can also used to prevent the urinary tract infections prior surgery. It has bactericidal effect against a wide range of gram-negative and gram-positive organisms. It takes effect through interfering with the normal function of the bacteria enzyme DNA gyrase and topoisomerase IV, further inhibiting the transcription and replication of bacterial DNA. This effect results in strand breakage of bacterial chromosome, supercoiling and resealing, further causing bacteria death.

References

https://en.wikipedia.org/wiki/Lomefloxacin
https://www.drugbank.ca/drugs/DB00978

Description

Lomefloxacin is a once-daily, third-generation quinolone antibiotic useful in the treatment of bacterial infections. The new fluorinated quinolone does not interfere with the metabolism of theophylline; it is efficacious against pathogens resistant to cephalosporins, penicillins and aminoglycosides.

Chemical Properties

colorless Needles

Originator

Hokuriku Seiyaku (Japan)

Uses

Anti bacterial.

Definition

ChEBI: A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.

Manufacturing Process

A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless needles, melting point 239.0-240.5°C.
By the usual manner the hydrochloride was prepared and recrystallized from water as colorless needles, melting point 290-300°C (decomp.).

brand name

Uniquin

Therapeutic Function

Antibacterial

Pharmaceutical Applications

A difluoropiperazinyl quinolone formulated as the hydrochloride salt for oral administration. The in-vitro activity is very similar to that of norfloxacin . It is active against Enterobacteriaceae and fastidious Gram-negative bacilli, including L. pneumophila. Activity against Campylobacter spp., Ps. aeruginosa, Acinetobacter and Chlamydia spp. is poor. It has reduced activity against staphylococci and poor activity against streptococci, L. monocytogenes, anaerobes and Mycobacterium spp.
A 400 mg oral dose achieves a concentration of 3–5 mg/L after 1–1.5 h. In escalating oral doses of 100, 400 and 800 mg to volunteers, the AUC was essentially proportional to the dosage, the mean plasma concentrations following 100, 400 and 800 mg doses being approximately 1.1, 4.7 and 7.5 mg/L, respectively.
Several metabolites have been described, accounting for <5% of the oral dose. Elimination occurs principally via the kidneys and 50–70% of a dose appears in the urine over 24 h. In patients with impaired renal function given 400 mg orally, the apparent elimination half-life ranged from 8 to 44 h, depending on the degree of renal failure. Non-renal clearance was also impaired, but there was no significant change in other pharmacokinetic parameters. The daily dosage (400 mg) should be reduced to 280 mg when the creatinine clearance falls below 30 mL/min. Hemodialysis has no effect on the plasma concentration. The effect of lomefloxacin on the plasma concentration of theophylline is clinically insignificant and no dosage adjustment is required.
The main adverse event is phototoxicity; other adverse events (mainly diarrhea, abdominal pain, skin reactions, dizziness, headache and insomnia) occur in about 10% of patients.
It is chiefly used in urinary tract infection, but is no longer widely available.

Clinical Use

1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (Maxaquin) is adifluorinated quinolone with a longer elimination half-life(7–8 hours) than other members of its class. It is the onlyquinolone for which once-daily oral dosing suffices. The oralbioavailability of lomefloxacin is estimated to be 95% to98%. Food slows, but does not prevent, its oral absorption.The extent of biotransformation of lomefloxacin is only about5%, and high concentrations of unchanged drug, rangingfrom 60% to 80%, are excreted in the urine. The comparativelylong half-life of lomefloxacin is apparently because ofits excellent tissue distribution and renal reabsorption and not because of plasma protein binding (only ~10%) or enterohepaticrecycling (biliary excretion is estimated to be ~10%).
Lomefloxacin has been approved for two primary indications. First, it is indicated for acute bacterial exacerbations of chronic bronchitis caused by H. influenzae or Moraxella (Branhamella) catarrhalis, but not if Streptococcus pneumoniae is the causative organism. Second, it is used for prophylaxis of infection following transurethral surgery. Lomefloxacin also finds application in the treatment of acute cystitis and chronic urinary tract infections caused by Gram-negative bacilli.

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Lomefloxacin Suppliers

ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from Lomefloxacin manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Lomefloxacin 98079-51-7
Price
US $125.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2021-06-07
Hebei Kangcang new material Technology Co., LTD
Product
Lomefloxacin 98079-51-7
Price
US $10.00/g
Min. Order
1g
Purity
98%
Supply Ability
20ton
Release date
2024-03-27
Dideu Industries Group Limited
Product
Lomefloxacin 98079-51-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-19

98079-51-7, LomefloxacinRelated Search:


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  • LOMEFLOXACIN BASE
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  • 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolin
  • 1-Ethyl-6,8-difluoro-7-(3-methylpiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
  • LFLX
  • LoMenfloxacin
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  • Lomefloxacino
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  • 3-quinolinecarboxylicacid,1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-pipe
  • dm-10
  • 1-Ethyl-6,8-Difluoro-1,4-Dihydror-7-(3-Methyl-1-Piperazinyl)-4-Oxo-3-QuinolinecarboxylicacidHydrochloride
  • LOMEFLOXACINHYDROCHLORIDE(SUBJECTTOPATENTFREE)
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  • DM 10 (bactericide)
  • SC 47111A
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  • 1-Ethyl 1-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperaziny1)-4-oxo-3-quinolinecarboxylic acid
  • 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-
  • Clfimono
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  • 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid
  • Lomefloxacin Solution in Methanol
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