ODQ

Product Name: ODQ
CAS No.: 41443-28-1
Chemical Name: ODQ
Synonyms: ODQ;ODQ,98%;ODQ inhibitor;ODQ - CAS 41443-28-1 - Calbiochem;[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one>ODQ1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE[ODQ]
CBNumber: CB2730905
Molecular Formula: C9H5N3O2
Formula Weight: 187.15
MOL File: 41443-28-1.mol

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ODQ Property

Melting point:: 160-170 °C
Boiling point:: 321.89°C (rough estimate)
Density: 1.3753 (rough estimate)
refractive index: 1.6500 (estimate)
RTECS: RO0913150
storage temp.: 2-8°C
solubility: ethanol: 1.2 mg/mL
form: powder
pka: 0.94±0.20(Predicted)
color: pale yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference: 41443-28-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O3636
Product name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Purity: powder
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: 495320
Product name: ODQ
Packaging: 10mg
Price: $230
Updated: 2024/03/01

TCI Chemical

Product number: O0400
Product name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Purity: >95.0%(GC)
Packaging: 25mg
Price: $162
Updated: 2024/03/01

Alfa Aesar

Product number: J62250
Product name: 1H-[1,2,4]Oxadiazolo[4,3-a]-quinoxalin-1-one, 98+%
Packaging: 10mg
Price: $96.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62250
Product name: 1H-[1,2,4]Oxadiazolo[4,3-a]-quinoxalin-1-one, 98+%
Packaging: 50mg
Price: $323.65
Updated: 2024/03/01

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ODQ Chemical Properties,Usage,Production

Description

ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC),?IC50?= 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2?ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1?ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5

Chemical Properties

ODQ is off-white to yellow powder

Uses

ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor.

Uses

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.

Definition

ChEBI: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one is a member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group. It has a role as an EC 4.6.1.2 (guanylate cyclase) inhibitor.

Biological Activity

ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.

Biochem/physiol Actions

H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.

storage

+4°C

References

1) Garthwaite?et al.?(1995),?Potent and Selective Inhibition of Nitric Oxide-sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; Mol. Pharmacol.?48?184 2) Schrammel?et al.?(1996),?Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase; Mol. Pharmacol.?50?1 3) Estevez?et al.?(1998),?Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor; J. Neurosci.?18?3708 4) Vandecasteele?et al.?(1998),?Role of the NO-cGMP in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes; J. Physiol.?506?653 5) Martins-Pinge?et al.?(1999),?Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats;?Hypertension?34?748

ODQ Preparation Products And Raw materials

Raw materials

Preparation Products

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ODQ Suppliers

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41443-28-1, ODQRelated Search:

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ODQ

2-OXA-3,5,9B-TRIAZA-CYCLOPENTA[A]NAPHTHALENE-1-ONE

1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE

1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE

ODQ,98%

ODQ1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one

1H-[1,2,4]Oxadiazolo[4,3-A]quinoxalin-1-one (9ci)

1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE[ODQ]

[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

ODQ - CAS 41443-28-1 - Calbiochem

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one&gt

ODQ inhibitor

41443-28-1

C9H5N3O2

Cell Signaling and Neuroscience

Cell Biology

BioChemical

G Proteins and Cyclic Nucleotides

Guanylyl Cyclase Inhibitors

Cyclic Nucleotide Metabolism

Cyclic Nucleotide related

Amines

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Antineoplastic

Signalling