Brompheniramine hydrogen maleate
- Product Name
- Brompheniramine hydrogen maleate
- CAS No.
- 980-71-2
- Chemical Name
- Brompheniramine hydrogen maleate
- Synonyms
- dimegan;dimetane;dimotane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate;BROMPHENIRAMINE MALEATE
- CBNumber
- CB2736194
- Molecular Formula
- C20H23BrN2O4
- Formula Weight
- 435.31
- MOL File
- 980-71-2.mol
Brompheniramine hydrogen maleate Property
- Melting point:
- 134-135°C
- Flash point:
- 9℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
- color
- White to Off-White
- λmax
- 261nm(lit.)
- Merck
- 14,1443
- Stability:
- Hygroscopic
- InChIKey
- SRGKFVAASLQVBO-BTJKTKAUSA-N
- LogP
- 3.565 (est)
- CAS DataBase Reference
- 980-71-2(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)
Safety
- Hazard Codes
- Xn,Xi,T,F
- Risk Statements
- 22-39/23/24/25-23/24/25-11
- Safety Statements
- 36-45-36/37-16-7
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- US4025000
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 38220090
N-Bromosuccinimide Price
- Product number
- B-043
- Product name
- Brompheniramine maleate solution
- Purity
- 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 1078008
- Product name
- (±)-Brompheniramine maleate salt
- Packaging
- 125mg
- Price
- $358
- Updated
- 2024/03/01
- Product number
- B5167
- Product name
- Brompheniramine Maleate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- J63922
- Product name
- Brompheniramine maleate
- Packaging
- 25mg
- Price
- $85.65
- Updated
- 2024/03/01
- Product number
- J63922
- Product name
- Brompheniramine maleate
- Packaging
- 100mg
- Price
- $249
- Updated
- 2021/12/16
Brompheniramine hydrogen maleate Chemical Properties,Usage,Production
Description
Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.
Chemical Properties
White Solid
Originator
Dimetane,Robins,US,1957
Uses
This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.
Uses
Antihistaminic;H1 Antagonist
Uses
An antihistamine and also an inhibitor of serotonin reuptake
Definition
ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Manufacturing Process
Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.
brand name
Dimetane (Wyeth).
Therapeutic Function
Antihistaminic
General Description
Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
Side effects
The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.
Brompheniramine hydrogen maleate Preparation Products And Raw materials
Raw materials
Preparation Products
Brompheniramine hydrogen maleate Suppliers
View Lastest Price from Brompheniramine hydrogen maleate manufacturers
- Product
- Brompheniramine hydrogen maleate 980-71-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 30 tons
- Release date
- 2023-04-17
- Product
- Brompheniramine hydrogen maleate 980-71-2
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Brompheniramine Maleate 980-71-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.76%
- Supply Ability
- 20tons
- Release date
- 2023-04-19