Brompheniramine hydrogen maleate

ChemicalBook > CAS DataBase List > Brompheniramine hydrogen maleate

Brompheniramine hydrogen maleate

Product Name: Brompheniramine hydrogen maleate
CAS No.: 980-71-2
Chemical Name: Brompheniramine hydrogen maleate
Synonyms: dimegan;dimetane;dimotane;ilvinmaleate;Rolabromophen;dimetanemaleate;Brompheniramine MaL;BroMpheniraMine hydr;parabromdylaminemaleate;BROMPHENIRAMINE MALEATE
CBNumber: CB2736194
Molecular Formula: C20H23BrN2O4
Formula Weight: 435.31
MOL File: 980-71-2.mol

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Brompheniramine hydrogen maleate Property

Melting point:: 134-135°C
Flash point:: 9℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form: Solid
color: White to Off-White
λmax: 261nm(lit.)
Merck: 14,1443
Stability:: Hygroscopic
InChIKey: SRGKFVAASLQVBO-BTJKTKAUSA-N
LogP: 3.565 (est)
CAS DataBase Reference: 980-71-2(CAS DataBase Reference)
EPA Substance Registry System: 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)

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Safety

Hazard Codes: Xn,Xi,T,F
Risk Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 36-45-36/37-16-7
RIDADR: 3249
WGK Germany: 3
RTECS: US4025000
TSCA: Yes
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 38220090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B-043
Product name: Brompheniramine maleate solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $50
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1078008
Product name: (±)-Brompheniramine maleate salt
Packaging: 125mg
Price: $358
Updated: 2024/03/01

TCI Chemical

Product number: B5167
Product name: Brompheniramine Maleate
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $91
Updated: 2024/03/01

Alfa Aesar

Product number: J63922
Product name: Brompheniramine maleate
Packaging: 25mg
Price: $85.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63922
Product name: Brompheniramine maleate
Packaging: 100mg
Price: $249
Updated: 2021/12/16

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Brompheniramine hydrogen maleate Chemical Properties,Usage,Production

Description

Brompheniramine is a first generation antihistamine of the propylamine class. It antagonizes histamine H₁ receptors (K_i = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine.

Chemical Properties

White Solid

Originator

Dimetane,Robins,US,1957

Uses

This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.

Uses

Antihistaminic;H1 Antagonist

Uses

An antihistamine and also an inhibitor of serotonin reuptake

Definition

ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.

Manufacturing Process

Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.

brand name

Dimetane (Wyeth).

Therapeutic Function

Antihistaminic

General Description

Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.

Side effects

The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.

Brompheniramine hydrogen maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Brompheniramine hydrogen maleate manufacturers

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Brompheniramine Maleate 980-71-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.76%
Supply Ability: 20tons
Release date: 2023-04-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: Brompheniramine hydrogen maleate 980-71-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Brompheniramine hydrogen maleate 980-71-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

980-71-2, Brompheniramine hydrogen maleateRelated Search:

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2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1)

2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)

dimegan

dimetane

dimetanemaleate

RS-brompheniramine maleate

dimotane

g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate

gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate

gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-butenedioate

ilvinmaleate

parabromdylaminemaleate

parabromodylaminemaleate

γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate

1-(n,n-dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate

1-p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate

BROMOPHENIRAMINE MALEATE

(+/-)-BROMPHENIRAMINE MALEATE SALT

BROMPHENIRAMINE MALEATE SALT

brompheniramine hydrogen maleate

BROMPHENIRAMINE MALEATE

BROMPHENIRAMINEMALEATE,USP

BROMPHENIRAMINE MALEATE, PHARMA

Bromopheniramine Maleate Salt

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BroMpheniraMine hydr

γ-(4-BroMophenyl)-N,N-diMethyl-

γ-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanamine,(2Z)-2-butenedioate (1:1)

Brompheniramine maleate solution

Brompheniramine maleate CRS

Rolabromophen

Brompheniramine MaL

3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate

Brompheniramine hydrogen maleate USP/EP/BP

Brompheniramine maleateQ: What is Brompheniramine maleate Q: What is the CAS Number of Brompheniramine maleate Q: What is the storage condition of Brompheniramine maleate Q: What are the applications of Brompheniramine maleate

TIANFU-CHEM 980-71-2 Brompheniramine hydrogen maleate

Brompheniramine Maleate (1078008)

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Brompheniramine maleate in methanol

Brompheniramine maleate 100 μg/ml Methanol

C10781600 (±)-BrompheniraminEmaleate

980-71-2

80-71-2

C4H4O4C16H19BrN2

C20H23BrN204

C20H23BrN2O4

C16H19BrN2C4H4O4C20H23BrN2O4

C16H19BrN2C4H4O4

C16H19BrN2C4H4O4C20H

C16H19BrN2C4H4

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