BICALUTAMIDE-D4
- Product Name
- BICALUTAMIDE-D4
- CAS No.
- 1185035-71-5
- Chemical Name
- BICALUTAMIDE-D4
- Synonyms
- Casodex-d4;ICI-176334-d4;(CI-176334-D4;BICALUTAMIDE-D4;[2H4]-Bicalutamide;Bicalutamide Impurity 17;N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4;N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide;Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-
- CBNumber
- CB2737393
- Molecular Formula
- C18H10D4F4N2O4S
- Formula Weight
- 434.4
- MOL File
- 1185035-71-5.mol
BICALUTAMIDE-D4 Property
- Melting point:
- 192-1940C
- Boiling point:
- 650.308±55.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.522±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
- pka
- 11.492±0.29(predicted)
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 22377
- Product name
- Bicalutamide-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 500μg
- Price
- $219
- Updated
- 2024/03/01
- Product number
- 22377
- Product name
- Bicalutamide-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 1mg
- Price
- $414
- Updated
- 2024/03/01
- Product number
- B1087-55A
- Product name
- Bicalutamide-d4
- Packaging
- 1mg
- Price
- $496
- Updated
- 2021/12/16
- Product number
- B382002
- Product name
- Bicalutamide-d4
- Packaging
- 10mg
- Price
- $1695
- Updated
- 2021/12/16
- Product number
- RDL0007231
- Product name
- BICALUTAMIDE-D4
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $2194.5
- Updated
- 2021/12/16
BICALUTAMIDE-D4 Chemical Properties,Usage,Production
Description
Bicalutamide-d4 is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.
Chemical Properties
BICALUTAMIDE-D4 is White Solid
Uses
BICALUTAMIDE-D4 is used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0
References
[1] SN FREEMAN BJA F WIP Mainwaring. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)[J]. British Journal of Cancer, 1989, 60 5: 664-668. DOI: 10.1038/bjc.1989.336
[2] DAVID MASIELLO. Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor*[J]. The Journal of Biological Chemistry, 2002, 28 1: 26321-26326. DOI: 10.1074/jbc.m203310200
[3] WENQING GAO J T D Juhyun Kim. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands.[J]. Pharmaceutical Research, 2006, 23 8: 1641-1658. DOI: 10.1007/s11095-006-9024-3
[4] DONGHUA YIN. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.[J]. Molecular Pharmacology, 2003, 63 1: 211-223. DOI: 10.1124/mol.63.1.211
BICALUTAMIDE-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
BICALUTAMIDE-D4 Suppliers
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