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Thevetiaflavone

Product Name
Thevetiaflavone
CAS No.
29376-68-9
Chemical Name
Thevetiaflavone
Synonyms
Thevetiaflavone;5-O-METHYLAPIGENIN;Apigenin 5-methylether;Apigenin 5-O-monomethyl ether;4',7-Dihydroxy-5-methoxyflavone;Flavone,4',7-dihydroxy-5-methoxy- (8CI);Apigenin-5-methyl ether,5-0-Methylapigenin;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
CBNumber
CB2748959
Molecular Formula
C16H12O5
Formula Weight
284.26
MOL File
Mol file
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Thevetiaflavone Property

Melting point:
263℃
Boiling point:
567.9±50.0 °C(Predicted)
Density 
1.420
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
6.67±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Arctom
Product number
AS027151
Product name
Thevetiaflavone
Purity
≥98%
Packaging
5mg
Price
$316
Updated
2021/12/16
CSNpharm
Product number
CSN14606
Product name
Thevetiaflavone
Packaging
1mg
Price
$416
Updated
2021/12/16
Arctom
Product number
CFN96124
Product name
Thevetiaflavone
Purity
≥98%
Packaging
5mg
Price
$513
Updated
2021/12/16
CSNpharm
Product number
CSN14606
Product name
Thevetiaflavone
Packaging
5mg
Price
$791
Updated
2021/12/16
Crysdot
Product number
CD32001723
Product name
Thevetiaflavone
Purity
95+%
Packaging
5mg
Price
$802
Updated
2021/12/16
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Thevetiaflavone Chemical Properties,Usage,Production

Uses

Thevetiaflavone inhibited the secretion of β-glucuronidase from neutrophils in rabbits, ED50 was 20μM. And it inhibited sarcoplasmic reticulum Ca2+-ATPase, when the concentration was 100μM, the inhibition rate was 69 %.

Preparation

The method for obtaining a refined extract from capers, comprising the following steps: a) making the concentrated capers crude extract go up to macroporous adsorption resin chromatography, and eluting with water and ethanol solution; b) eluting with ethanol solution , that is, the refined extract of capers.

Biological Activity

Thevetiaflavone can up-regulate the expression of Bcl-2 and down-regulate the expression of Bax and caspase-3.

in vivo

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that it decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction , including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. It reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of the vetiaflavone in vivo and its application in the clinic.

Thevetiaflavone Preparation Products And Raw materials

Raw materials

Preparation Products

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Thevetiaflavone Suppliers

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29376-68-9, ThevetiaflavoneRelated Search:

Hydroxyecdysone beta-Eudesmol 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Artemether (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one hydroxygenkwanin beta-Sitosterol MOSLOFLAVONE alpha-Terpineol alpha-Cyperone Basic Red 9 Apigenin

  • 5-O-METHYLAPIGENIN
  • 4',7-Dihydroxy-5-methoxyflavone
  • Apigenin 5-methylether
  • 7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one
  • 4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-
  • Apigenin 5-O-monomethyl ether
  • Apigenin-5-methyl ether,5-0-Methylapigenin
  • Flavone,4',7-dihydroxy-5-methoxy- (8CI)
  • Thevetiaflavone
  • ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
  • 29376-68-9
  • Miscellaneous Natural Products