6-Quinolinecarboxylic acid
- Product Name
- 6-Quinolinecarboxylic acid
- CAS No.
- 10349-57-2
- Chemical Name
- 6-Quinolinecarboxylic acid
- Synonyms
- AKOS BBS-00005339;TIMTEC-BB SBB003821;IFLAB-BB F0406-3604;Chinolin-6-carbonsure;6-Quinolinecarboxylicaci;6-QUINOLINECARBOXYLIC ACID;QUINOLINE-6-CARBOXYLIC ACID;CHINOLINE-6-CARBOXYLIC ACID;Butanoicacid,4-chloro-7-oxo-;Quinoline-6-CarboxylicAcid98%
- CBNumber
- CB2750426
- Molecular Formula
- C10H7NO2
- Formula Weight
- 173.17
- MOL File
- 10349-57-2.mol
6-Quinolinecarboxylic acid Property
- Melting point:
- 293-294 °C
- Boiling point:
- 303.81°C (rough estimate)
- Density
- 1.2427 (rough estimate)
- refractive index
- 1.5200 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Practically insoluble in water
- pka
- 3.05±0.30(Predicted)
- form
- Crystalline Powder
- color
- Beige to brown
- InChI
- InChI=1S/C10H7NO2/c12-10(13)8-3-4-9-7(6-8)2-1-5-11-9/h1-6H,(H,12,13)
- InChIKey
- VXGYRCVTBHVXMZ-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(C(O)=O)=CC=2)C=CC=1
- CAS DataBase Reference
- 10349-57-2(CAS DataBase Reference)
- EPA Substance Registry System
- 6-Quinolinecarboxylic acid (10349-57-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- Q0077
- Product name
- 6-Quinolinecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- Q0077
- Product name
- 6-Quinolinecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $349
- Updated
- 2025/07/31
- Product number
- Q990060
- Product name
- Quinoline-6-carboxylicAcid
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 288565
- Product name
- Quinoline-6-caRboxylic acid
- Packaging
- 5g
- Price
- $378
- Updated
- 2021/12/16
- Product number
- 010038
- Product name
- Quinoline-6-carboxylic acid
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
6-Quinolinecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
beige to brown crystalline powder
Uses
6-Quinolinecarboxylic acid is a vital compound and can be used to synthesise 6-Quinolinecarboxaldehyde, 6-(Aminomethyl)quinoline, and Quinolin-6-ylmethanol, etc.
Synthesis
91-62-3
10349-57-2
6-Methylquinoline (100.0 mg, 0.70 mmol) was dissolved in a mixed solution of H2O (1.0 mL) and H2SO4 (0.25 mL) at 0 °C and chromium trioxide (272.0 mg, 2.72 mmol) was added in batches. The reaction mixture was refluxed for 24 hours. After completion of the reaction, it was cooled to room temperature and the precipitated crystalline bisulfate precipitate was removed by filtration. The filtrate was dissolved in 10% aqueous sodium hydroxide solution, washed with hexane and the pH was adjusted to acidic with acetic acid to precipitate 6-quinolinecarboxylic acid. The precipitate was collected to give 85.0 mg of 6-quinolinecarboxylic acid in 70% yield. The product could be used in subsequent steps without further purification. The product was characterized as follows: 1H NMR (300 MHz, DMSO-d6) δ 7.61 (dd, 1H, J1 = 8.3 Hz, J2 = 4.2 Hz), 8.08 (d, 1H, J = 8.8 Hz), 8.20 (dd, 1H, J1 = 8.8 Hz, J2 = 1.7 Hz), 8.56 (d, 1H, J = 8.2 Hz), 8.67 (m, 1H, J = 8.2 Hz), 8.67 (m, 1H, J = 8.2 Hz), 8.56 (d, 1H, J = 8.2 Hz), 8.56 (m, 1H, J = 8.2 Hz) 8.67 (m, 1H), 9.00 (dd, 1H, J1 = 4.1 Hz, J2 = 1.5 Hz), 13.20 (br s, 1H); 13C NMR (300 MHz, DMSO-d6) δ 122.9, 127.9, 129.2, 129.5, 130.0, 131.7, 138.2, 150.0, 153.4, 167.4, 167.0, 153.4, 167.4, 167.4, 167.4, 167.4, 167.4, 167.4 153.4, 167.7; ESI-MS m/z 196 [M + Na]+, 174 [M + H]+. Molecular formula: C10H7NO2.
References
[1] Chemical Communications, 2002, # 2, p. 180 - 181
[2] Patent: WO2008/43839, 2008, A1. Location in patent: Page/Page column 10; 11
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 22, p. 9578 - 9597
[4] Heterocycles, 2011, vol. 83, # 7, p. 1649 - 1658
[5] Monatshefte fuer Chemie, 1891, vol. 12, p. 309
6-Quinolinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Quinolinecarboxylic acid Suppliers
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- Country
- The Netherlands
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View Lastest Price from 6-Quinolinecarboxylic acid manufacturers
- Product
- 6-Quinolinecarboxylic acid 10349-57-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 6-Quinolinecarboxylic acid 10349-57-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 6-Quinolinecarboxylic acid 10349-57-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13