ChemicalBook > CAS DataBase List > Norgestrel

Norgestrel

Product Name
Norgestrel
CAS No.
6533-00-2
Chemical Name
Norgestrel
Synonyms
sh850;wy3707;sh70850;monovar;Neogest;Ovrette;fh122-a;NORPLANT;OVRETTE(R);NORGESTREL
CBNumber
CB2752440
Molecular Formula
C21H28O2
Formula Weight
312.45
MOL File
6533-00-2.mol
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Norgestrel Property

Melting point:
239-241 °C(lit.)
Boiling point:
392.36°C (rough estimate)
Density 
1.0697 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly, Sonicated), Dichloromethane (Slightly), Methanol (Slightly)
pka
13.09±0.40(Predicted)
color 
Crystals from diethyl ether-hexane
InChIKey
WWYNJERNGUHSAO-XUDSTZEESA-N
CAS DataBase Reference
6533-00-2(CAS DataBase Reference)
EPA Substance Registry System
Norgestrel (6533-00-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
22-36
WGK Germany 
3
RTECS 
JF8259000
HS Code 
2937230000
Hazardous Substances Data
6533-00-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 5010mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2487
Product name
Norgestrel
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200MG
Price
$253
Updated
2024/03/01
Sigma-Aldrich
Product number
N1250000
Product name
Norgestrel
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
n1250000
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
1472000
Product name
Norgestrel
Packaging
125mg
Price
$358
Updated
2024/03/01
Cayman Chemical
Product number
10006319
Product name
Norgestrel
Purity
≥95%
Packaging
100mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
10006319
Product name
Norgestrel
Purity
≥95%
Packaging
500mg
Price
$107
Updated
2024/03/01
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Norgestrel Chemical Properties,Usage,Production

Description

Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component. In vivo, norgestrel administered via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.

Chemical Properties

White Solid

Uses

Progestogen; oral contraceptive. The bioactive enantiomer is levorotatory

Uses

A metabolite of Norgestrel.

Uses

Protected D-(-)-Norgestrel

Uses

A glucuronide metabolite of Levonorgestrel.

Uses

An intermediate to the glucuronide metabolite of Levonorgestrel.

Uses

analgesic, antipyretic

Uses

It is an excellent progestational and ovulation inhibiting steroid. The bioactive enantiomer is levorotatory. Progestogen; oral contraceptive.

Definition

ChEBI: Levonorgestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin, a synthetic oral contraceptive and a female contraceptive drug. It is functionally related to a norgestrel. It is an enantiomer of a dexonorgestrel.

brand name

Ovrette (Wyeth).

General Description

Norgestrel, (17α)-(±)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, and levonorgestrel, (17α)-(-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one,have a C13 ethyl group instead of the C13 methyl but haveprogestational properties similar to those of norethindrone,with decreased androgenic effects. The ethyl group apparentlyprovides unfavorable steric interactions with the ARthat reduce the affinity compared with that with the PRs.Norgestrel is a racemic mixture, while levonorgestrel is thesingle active levorotatory enantiomer. Norgestrel is usedonly in oral contraceptives. Levonorgestrel is used in bothoral combination birth control products and polymeric implantsthat provide contraception for up to 5 years.

Safety Profile

Human reproductive effects byingestion and implant: menstrual cycle changes ordisorders and female fertility index changes. Anexperimental teratogen. Experimental reproductiveeffects. Questionable carcinogen with experimentalneoplastigenic data. An o

Norgestrel Preparation Products And Raw materials

Raw materials

Preparation Products

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Norgestrel Suppliers

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View Lastest Price from Norgestrel manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Norgestrel 6533-00-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Nantong Guangyuan Chemicl Co,Ltd
Product
Levonorgestrel 6533-00-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-03
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Norgestrel 6533-00-2
Price
US $0.00-0.00/KG
Min. Order
50g
Purity
98%-102%;USP
Supply Ability
10KG
Release date
2021-06-18

6533-00-2, NorgestrelRelated Search:

Ethanol Ethyl acetate Ethylparaben Ethyl acrylate Ethyl vanillin Norethindrone Ethyl 4-hydroxy-3-methoxycinnamate Ethisterone Dehydroepiandrosterone Venlafaxine hydrochloride Oxaprozin Etonogestrel (-)-NORGESTREL 98%,(-)-NORGESTREL 98 Norgestrel (L-),D(minus)-norgestrel,L-NORGESTREL,LEVONORGESTREL (D-(-)-NORGESTREL) 13-ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one butyrate Progesterone Norgestrel-D5 norgestrel acetate

  • dl-13b-ethyl-17a-ethynyl-17b-hydroxygon-4-en-3-one
  • 4-GONEN-13BETA-ETHYL-17ALPHA-ETHYNYL-17BETA-OL-3-ONE
  • 4-PREGNEN-13BETA-ETHYL-18,19-DINOR 17BETA-OL-3-ONE-20-YNE
  • 4-ESTREN-17-ALPHA-ETHYNYL-18-HOMO-17-BETA-OL-3-ONE(+/-)
  • D(-)-NORGESTREL
  • D-NORGESTREL
  • (+-)-13-ethyl-17-hydroxy-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one
  • 13-ethyl-17-hydroxy-19-dinorpregn-4-en-20-yn-3-on(17-alpha)-(+-)-1
  • monovar
  • sh70850
  • sh850
  • wy3707
  • (17a)-(-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
  • Neogest
  • Ovrette
  • (+-)-13-Ethyl-17a-ethynyl-17-hydroxygon-4-en-3-one
  • (+-)-17a-Ethynyl-13b-ethylgon-4-en-17b-ol-3-one
  • (+-)-17a-Ethynyl-13-ethyl-17-hydroxygon-4-en-3-one
  • 13-Ethyl-17a-ethynyl-17b-hydroxy-4-gonen-3-one
  • 13-beta-ethyl-17-beta-hydroxy-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one
  • Norgestrel (DL-)
  • LEVONORGESTRAL
  • Norgestrel Solution, 100ppm
  • Norgestrel IP
  • alpha-norgestrel
  • dl-13-beta-ethyl-17-alpha-ethynyl-17-beta-hydroxygon-4-en-3-one
  • dl-13-beta-ethyl-17-alpha-ethynyl-19-nortestosterone
  • dl-norgestrel
  • fh122-a
  • ldnorgestrel
  • Methylnorethindrone
  • 18,19-Dinor-17a-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (+-)- (8CI)
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17a)-(+-)- (9CI)
  • a-Norgestrel
  • dl-11b-Ethyl-17a-ethynyl-17b-hydroxygon-4-en-3-one
  • 18-Methyl Norgestrel
  • 17-ALPHA-ETHYNYL-18-HOMO-19-NORTESTOSTERONE
  • OVRETTE(R)
  • NORPLANT
  • NORGESTREL
  • NORGESTREL(LEVO)
  • 18,19-Dinor-17-alpha-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (+-)
  • rac-(13R*)-13-Ethyl-17α-hydroxy-18,19-dinorpregna-4-ene-20-yne-3-one
  • Norgestrel (125 mg)
  • 18,19-DINOR-13-BETA-ETHYL-17-BETA-HYDROXY-4-PREGNEN-20-YN-3-ONE
  • 18,19-DINOR-4-PREGNEN-20-YN-3-ONE
  • 13BETA-ETHYL-17ALPHA-ETHYNYL-17BETA-HYDROXYGON-4-EN-3-ONE
  • (+/-)-13-ETHYL-17ALPHA-HYDROXY-18,19-DINORPREGN-4-EN-20-YN-3-ONE
  • (±) Di-Norgestrel
  • (17α)-(+/-)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
  • Levonorgestrel-D6
  • Levonorgestrel-d6((-)-Norgestrel-2,2,4,6,6,10-d6)
  • Novogestrel
  • Norgestrel CRS
  • Norgestrel RS
  • Norgestrel USP/EP/BP
  • Norgestrel Steroids Powders
  • (+/-)-NORGESTREL-D6