Ethisterone
- Product Name
- Ethisterone
- CAS No.
- 434-03-7
- Chemical Name
- Ethisterone
- Synonyms
- Progestoral;17A-ETHYNYLTESTOSTERONE;Prone;Pranone;Pregnin;Gestoral;NSC-9565;Prodoxan;Produxan;Prolutol
- CBNumber
- CB1207877
- Molecular Formula
- C21H28O2
- Formula Weight
- 312.45
- MOL File
- 434-03-7.mol
Ethisterone Property
- Melting point:
- 263-269 °C (lit.)
- Boiling point:
- 392.36°C (rough estimate)
- alpha
- D23 +23.8° (dioxane); D25 -32.0° (pyridine)
- Density
- 1.0697 (rough estimate)
- refractive index
- 33 ° (C=1, Pyridine)
- storage temp.
- room temp
- solubility
- Soluble to 0.05 mg/mL (0.16 mM) in DMSO
- pka
- 13.10±0.60(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- biological source
- synthetic (organic)
- Water Solubility
- soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
- Merck
- 14,3741
- BRN
- 1889895
- InChIKey
- CHNXZKVNWQUJIB-CEGNMAFCSA-N
- CAS DataBase Reference
- 434-03-7
- NIST Chemistry Reference
- Ethisterone(434-03-7)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 40-48-61
- Safety Statements
- 22-24/25-45-53
- RIDADR
- UN 2811
- WGK Germany
- 3
- RTECS
- TU5570250
- HS Code
- 29372390
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
N-Bromosuccinimide Price
- Product number
- E1001
- Product name
- Ethisterone
- Purity
- ≥99% (HPLC)
- Packaging
- 25g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- 1261117
- Product name
- Ethisterone
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1060
- Updated
- 2025/07/31
- Product number
- 22893
- Product name
- Ethisterone
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22893
- Product name
- Ethisterone
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- E1001
- Product name
- Ethisterone
- Purity
- ≥99% (HPLC)
- Packaging
- 100g
- Price
- $591
- Updated
- 2025/07/31
Ethisterone Chemical Properties,Usage,Production
Description
Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.
Chemical Properties
Off-White Powder
Originator
Lutocyclin,Ciba
Uses
Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and?gene transfection assay.
Uses
Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
Definition
ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Manufacturing Process
0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
Therapeutic Function
Progestin
General Description
Ethisterone is a?progestogen. It is a danazol derivative.
Biochem/physiol Actions
Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.
References
[1] L. MCROBB . Structure–activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay[J]. Journal of Steroid Biochemistry and Molecular Biology, 2008, 110 1: Pages 39-47. DOI: 10.1016/j.jsbmb.2007.10.008
[2] J.M. GLEDHILL . Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus[J]. Journal of Steroid Biochemistry and Molecular Biology, 1992, 43 4: Pages 289-296. DOI: 10.1016/0960-0760(92)90163-d
Ethisterone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethisterone manufacturers
- Product
- Ethisterone 434-03-7
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
- Product
- Ethisterone 434-03-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-07-31
- Product
- Ethisterone 434-03-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000000000
- Release date
- 2022-12-20