ChemicalBook > CAS DataBase List > Ethisterone

Ethisterone

Product Name
Ethisterone
CAS No.
434-03-7
Chemical Name
Ethisterone
Synonyms
Progestoral;17A-ETHYNYLTESTOSTERONE;Prone;Pranone;Pregnin;Gestoral;NSC-9565;Prodoxan;Produxan;Prolutol
CBNumber
CB1207877
Molecular Formula
C21H28O2
Formula Weight
312.45
MOL File
434-03-7.mol
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Ethisterone Property

Melting point:
263-269 °C (lit.)
Boiling point:
392.36°C (rough estimate)
alpha 
D23 +23.8° (dioxane); D25 -32.0° (pyridine)
Density 
1.0697 (rough estimate)
refractive index 
33 ° (C=1, Pyridine)
storage temp. 
room temp
solubility 
Soluble to 0.05 mg/mL (0.16 mM) in DMSO
pka
13.10±0.60(Predicted)
Water Solubility 
soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C).
Merck 
14,3741
BRN 
1889895
InChIKey
CHNXZKVNWQUJIB-CEGNMAFCSA-N
CAS DataBase Reference
434-03-7
NIST Chemistry Reference
Ethisterone(434-03-7)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
40-48-61
Safety Statements 
22-24/25-45-53
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
TU5570250
HS Code 
29372390
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1001
Product name
Ethisterone
Purity
≥99% (HPLC)
Packaging
25g
Price
$252
Updated
2024/03/01
Alfa Aesar
Product number
J63580
Product name
Ethisterone, 98%
Packaging
5g
Price
$176
Updated
2024/03/01
Alfa Aesar
Product number
J63580
Product name
Ethisterone, 98%
Packaging
25g
Price
$382
Updated
2024/03/01
Cayman Chemical
Product number
22893
Product name
Ethisterone
Purity
≥95%
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22893
Product name
Ethisterone
Purity
≥95%
Packaging
5g
Price
$93
Updated
2024/03/01
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Ethisterone Chemical Properties,Usage,Production

Description

Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.

Chemical Properties

Off-White Powder

Originator

Lutocyclin,Ciba

Uses

Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone

Uses

Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay and?gene transfection assay.

Definition

ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.

Manufacturing Process

0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.

Therapeutic Function

Progestin

General Description

Ethisterone is a?progestogen. It is a danazol derivative.

Biochem/physiol Actions

Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.

Ethisterone Preparation Products And Raw materials

Raw materials

Dehydroepiandrosterone

Preparation Products

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Ethisterone Suppliers

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View Lastest Price from Ethisterone manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Ethisterone 434-03-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ethisterone 434-03-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-23
Nantong Guangyuan Chemicl Co,Ltd
Product
Ethisterone 434-03-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-02

434-03-7, EthisteroneRelated Search:

Testosterone 4'-Hydroxyacetophenone Zearalenone Quinocetone Androstenedione CHLOROPHOSPHONAZO III 2'-Hydroxyacetophenone Clethodim Gestrinone Norgestrel 6-Methyl-5-hepten-2-one 19-NOR-4-ETHISTERONE DIMETHISTERONE Progesterone Acetylene Oracon 2-hydroxy methylene ethisterone 2-(hydroxymethyl)ethisterone

  • 4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE
  • 4,17a-pregnen-17b-ol-20-yn-3-one
  • 4,17A-PREGNEN-17B-OL-20-YNE
  • 4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE
  • (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
  • ANHYDROHYDROXYPROGESTERONE
  • ANHYDROXYPROGESTERONE
  • 17BETA-HYDROXY-4,17ALPHA-PREGNEN-20-YN-3-ONE
  • 17b-hydroxy-4,17a-pregnen-20-yn-3-one
  • (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • Ethisterone, 98%, a progestogen hormone being considered to treat prostate cancer
  • pregneninolo
  • 17A-ETHYNYL-4-ANDROSTEN-17B-OL-3-ONE
  • 17a-ethynyl-17b-hydroxy-4-androsten-3-one
  • 17A-ETHYNYLTESTOSTERONE
  • 17ALPHA-ETHYNYLTESTOSTERONE
  • 17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
  • (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHY
  • ETHISTERONE(RG)
  • Ethisterone,17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one
  • ETHISTERONE(RG)(CALL)
  • Ethisterone 0
  • (17α)-17-hydroxy-pregn-4-en-20-yn-3-one
  • ETHINYL TESTOSTERONE
  • ETHISTERONE
  • ETHYNYLTESTOSTERONE
  • ETHYNYLANDROSTENOLONE
  • (17-alpha)-pregn-4-en-20-yn-3-on
  • Gestoral
  • Lucorteum Oral
  • lucorteumoral
  • Lutidon Oral
  • lutidonoral
  • Lutocyclin
  • Lutocyclol
  • Lutocylol
  • Nalutoral
  • NSC-9565
  • Nugestoral
  • Ora-Lutin
  • Pranone
  • Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17alpha)-
  • Pregneninolone
  • Pregnin
  • Primolut C
  • primolutc
  • Prodoxan
  • Prodroxan
  • Produxan
  • Progestab
  • Progestin P
  • progestinp
  • Progestolets
  • Progestoral
  • Prolutol
  • Proluton C
  • 17-alpha-ethinyltestosterone
  • 17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one