ChemicalBook > CAS DataBase List > alpha-Angelica lactone

alpha-Angelica lactone

Product Name
alpha-Angelica lactone
CAS No.
591-12-8
Chemical Name
alpha-Angelica lactone
Synonyms
2(3H)-Furanone, 5-methyl-;5-METHYL-2(3H)-FURANONE;α-Angelica lactone;5-Methylfuran-2(3H)-one;ANGELICALACTONE;3-PENTEN-4-OLIDE;4-HYDROXY-3-PENTENOIC ACID GAMMA-LACTONE;FEMA 3293;A-ANGELICALACTONE;A-ANGELIC LACTONE
CBNumber
CB2760151
Molecular Formula
C5H6O2
Formula Weight
98.1
MOL File
591-12-8.mol
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alpha-Angelica lactone Property

Melting point:
13-17 °C(lit.)
Boiling point:
55-56 °C12 mm Hg(lit.)
Density 
1.092 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.448(lit.)
FEMA 
3293 | 4-HYDROXY-3-PENTENOIC ACID LACTONE
Flash point:
155 °F
storage temp. 
2-8°C
solubility 
Chloroform, Ethyl Acetate
form 
Oil
pka
pK1:4.3 (25°C)
Specific Gravity
1.101.092
color 
Clear Light Yellow
Odor
at 10.00 % in dipropylene glycol. sweet solvent nutty tonka coumarin tobacco
Odor Type
coconut
Water Solubility 
5 g/100 mL (25 ºC)
JECFA Number
221
Merck 
14,647
BRN 
108394
LogP
0.84
CAS DataBase Reference
591-12-8(CAS DataBase Reference)
NIST Chemistry Reference
2(3H)-Furanone, 5-methyl-(591-12-8)
EPA Substance Registry System
5-Methyl-2(3H)-furanone (591-12-8)
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Safety

Safety Statements 
24/25
RIDADR 
NA 1993 / PGIII
WGK Germany 
2
RTECS 
LU5075000
F 
10-21
TSCA 
Yes
HS Code 
29322090
Toxicity
LD50 orl-mus: 2800 mg/kg DCTODJ 3,249,80
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H303May be harmfulif swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W329304
Product name
α-Angelica lactone
Purity
98%, FG
Packaging
100g
Price
$181
Updated
2024/03/01
Sigma-Aldrich
Product number
W329304
Product name
α-Angelica lactone
Purity
98%, FG
Packaging
250g
Price
$340
Updated
2024/03/01
Sigma-Aldrich
Product number
W329304
Product name
α-Angelica lactone
Purity
98%, FG
Packaging
1kg
Price
$847
Updated
2024/03/01
Sigma-Aldrich
Product number
A86406
Product name
α-Angelica lactone
Purity
98%
Packaging
10g
Price
$125
Updated
2024/03/01
TCI Chemical
Product number
A1090
Product name
alpha-Angelicalactone
Purity
>98.0%(GC)
Packaging
25g
Price
$58
Updated
2024/03/01
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alpha-Angelica lactone Chemical Properties,Usage,Production

Chemical Properties

clear colorless to straw yellow liquid

Chemical Properties

α-Angelica lactone has a sweet, herbaceous odor reminiscent of tobacco.

Occurrence

Reported found in grape, white bread, soy bean and licorice.

Uses

alpha-Angelicalactone acts as acancer chemopreventive agent. It is used in the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver. It is used in oral care formulations to round out mint notes and in coffee flavors.

Definition

ChEBI: Alpha-angelica lactone is an angelica lactone and a butenolide. It is functionally related to a but-3-en-4-olide. It is a tautomer of a beta-angelica lactone.

Preparation

By dry distillation of levulinic acid

Application

alpha-Angelica lactone finds occasional use in the reconstitution of essential oils. lts intensely sweet-herbaceous, almost tobacco-like odor makes this chemical interesting for application in new fragrance types. However, it would be wise to investigate its pharmacological and dermatological properties first.

Taste threshold values

Taste characteristics at 100 ppm: sweet, creamy, coconut, vanilla hay and coumarin-like nuances

General Description

α-Angelica lactone, a cyclic lactone that occurs naturally in tobacco, is generally used in tobacco flavoring.

Biochem/physiol Actions

Plant-derived cancer chemopreventive agent. Increases the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits acrid smoke and irritating fumes.

alpha-Angelica lactone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from alpha-Angelica lactone manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
alpha-Angelica lactone 591-12-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Hebei Zhuanglai Chemical Trading Co Ltd
Product
alpha-Angelica lactone 591-12-8
Price
US $55.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-19
Hebei Chuanghai Biotechnology Co,.LTD
Product
alpha-Angelica lactone 591-12-8
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-16

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