ChemicalBook > CAS DataBase List > ISOLIQUIRITIN

ISOLIQUIRITIN

Product Name: ISOLIQUIRITIN
CAS No.: 5041-81-6
Chemical Name: ISOLIQUIRITIN
Synonyms: Isoliquiritoside;neoisoliquritin;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one;Aids004475;Aids-004475;ISOLIQUIRITIN;Isoliquiriiin;Isoliquiritin-RM;Isoliquiritin, >=98%;ISOLIQUIRITIN USP/EP/BP
CBNumber: CB2765101
Molecular Formula: C21H22O9
Formula Weight: 418.39
MOL File: 5041-81-6.mol

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ISOLIQUIRITIN Property

Melting point:: 185-186℃
Boiling point:: 743.5±60.0 °C(Predicted)
Density: 1.528
storage temp.: 4°C, protect from light
solubility: Soluble in methan
form: powder
pka: 7.46±0.35(Predicted)
color: Ochre
biological source: plant
InChI: InChI=1/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/s3
InChIKey: YNWXJFQOCHMPCK-RQOZFYCLNA-N
SMILES: [C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1=CC=C(/C=C/C(=O)C2C=CC(O)=CC=2O)C=C1 |&1:0,1,3,4,6,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB01045
Product name: Isoliquiritin
Purity: ≥90% (LC/MS-ELSD)
Packaging: 1mg
Price: $313
Updated: 2025/07/31

TCI Chemical

Product number: I1144
Product name: Isoliquiritin
Packaging: 25MG
Price: $228
Updated: 2025/07/31

Cayman Chemical

Product number: 30270
Product name: Isoliquiritin
Packaging: 25mg
Price: $573
Updated: 2024/03/01

Cayman Chemical

Product number: 30270
Product name: Isoliquiritin
Packaging: 50mg
Price: $793
Updated: 2024/03/01

Cayman Chemical

Product number: 30270
Product name: Isoliquiritin
Packaging: 5mg
Price: $178
Updated: 2024/03/01

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ISOLIQUIRITIN Chemical Properties,Usage,Production

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice.

Uses

It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Definition

ChEBI: A monosaccharide derivative that is trans-chalcone substituted by hydroxy groups at positions 2' and 4' and a beta-D-glucopyranosyloxy group at position 4 respectively.

Biological Activity

Isoliquiritin triggers apoptotic cell death by increasing the levels of p53 and p21 in A549 non-small cell lung cancer cells while also inhibiting the p53-dependent pathway and revealing interactions with Akt activities. Futher, Isoliquiritin has demonstrated neuroprotective activity against oxidative stress and has the capability to restrain the growth of microbial pathogens.

in vivo

Isoliquiritin (0.31-3.1 mg/kg, i.p., once a day for 5 days) inhibits granuloma angiogenesis in mice^[1].
Isoliquiritin (10-40 mg/kg, oral gavage) shows antidepressant-like effects in FST and TST tests in mice^[2].
Isoliquiritin ((10 mg/kg/bw/day, p.o.) shows anti-oxidative and anti-Inflammatory properties, and relieves cationic BSA-Induced membranous glomerulonephritis in experimental rat model^[5].

Animal Model:	Mice in Forced Swimming Test (FST) and the Tail Suspension Test (TST)^[2]
Dosage:	10, 20 and 40 mg/kg
Administration:	oral gavage
Result:	Reduced the immobility time in the FST and TST in mice. Increased 5-HT and NE level and Reduced the ratio of 5-HIAA/5-HT in the hippocampus, hypothalamus and cortex.

target

HIV

ISOLIQUIRITIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ISOLIQUIRITIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Isoliquiritin 5041-81-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: isoliquiritin 5041-81-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: isoliquiritin 5041-81-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

5041-81-6, ISOLIQUIRITINRelated Search:

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ISOLIQUIRITIN

(E)-1-(2,4-Dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-2-propen-1-one

[(E)-2',4'-Dihydroxychalcone-4-yl]β-D-glucopyranoside

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(.beta.-D-glucopyranosyloxy)phenyl]-, (2E)-

Aids004475

Aids-004475

neoisoliquritin

2',4,4'-Trihydroxychalcone 4-(beta-D-glucopyranoside)

2',4,4'-Trihydroxychalcone 4-beta-D-glucopyranoside

Isoliquiritoside

4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl beta-D-glucopyranoside

Isoliquiritin, >=98%

Isoliquiriiin

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-, (2E)-

Isoliquiritin（Isoliquiritoside）

ISOLIQUIRITIN USP/EP/BP

(E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one

4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl b...

(E)-1-(2,4-Dihydroxyphenyl)-3-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one

Isoliquiritin-RM

5041-81-6

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

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