Dioscin

ChemicalBook > CAS DataBase List > Dioscin

Product Name: Dioscin
CAS No.: 19057-60-4
Chemical Name: Dioscin
Synonyms: ioscin;DIOSCIN;dioscine;DIOSCIN(P);Ccris 4123;DIOSCIN(RG);collettisideiii;Polyphyllin lll;Dioscin USP/EP/BP;Dioscin 19057-60-4
CBNumber: CB2768036
Molecular Formula: C45H72O16
Formula Weight: 869.06
MOL File: 19057-60-4.mol

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Dioscin Property

Melting point:: 275～277℃
alpha: D13 -115° (c = 0.373 in ethanol)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
pka: 12?+-.0.70(Predicted)
form: Solid
color: White to Off-White

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Safety

Safety Statements: 24/25
HS Code: 29389090
Toxicity: mouse,LD50,subcutaneous,> 300mg/kg (300mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #91-271224,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11834
Product name: Dioscin
Purity: ≥95%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 11834
Product name: Dioscin
Purity: ≥95%
Packaging: 25mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 11834
Product name: Dioscin
Purity: ≥95%
Packaging: 50mg
Price: $481
Updated: 2024/03/01

Cayman Chemical

Product number: 11834
Product name: Dioscin
Purity: ≥95%
Packaging: 100mg
Price: $841
Updated: 2024/03/01

TRC

Product number: D485230
Product name: Dioscin
Packaging: 2.5g
Price: $1255
Updated: 2021/12/16

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Dioscin Chemical Properties,Usage,Production

Description

Dioscin is extracted from Dioscorea nipponica. Rhizoma Dioscoreae Nipponicae is the dry rhizome of this plant. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it can also be used externally to treat sore carbuncle swollen. Rhizoma Dioscoreae Nipponicae is commonly used in the northeast region, Shanxi province, and Shandong province of China.

Physical properties

Appearance: white powder. Solubility: insoluble in water, petroleum ether, and benzene; soluble in methanol, ethanol, and acetic acid; slightly soluble in acetone and amyl alcohol. Melting point: 294–296℃. Specific optical rotation: ?115° (c?=?0.373, ethanol).

History

Japanese scientists firstly reported and analyzed the structure of dioscin isolated from the saponins of Japanese Dioscoreaceae. V . However, the biological activities of dioscin have not attracted the interests of scientists until the late 1990s and the beginning of this century. It is now believed that dioscin may have therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, antiinflammatory, and antitumor effects. After the implementation of standardization of traditional Chinese medicine, dioscin as the quality control specification of Dioscorea nipponica Makino and other traditional Chinese medicine has attracted more attentions and researches. In China, dioscin tablets have been used to treat hyperlipidemia in the clinical practice. However, no corresponding drugs are available on the market in other countries. In addition, dioscin is also an important predecessor for synthesizing steroid hormones . Dioscorea nipponica Makino, which is used to extract dioscin, primarily comes from wild plants, whose resources are limited.

Uses

Dioscin, a natural steroid saponin that has been shown to promote anticancer activity against several forms of cancers. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

Definition

ChEBI: Dioscin is a spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage. It has a role as a metabolite, an antifungal agent, an antiviral agent, an antineoplastic agent, an anti-inflammatory agent, a hepatoprotective agent, an apoptosis inducer and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a spirostanyl glycoside, a spiroketal, a hexacyclic triterpenoid and a trisaccharide derivative. It is functionally related to a diosgenin. It derives from a hydride of a spirostan.

Indications

This drug was recorded in the national standards for chemical drugs, volume 5. Dioscin tablets, containing total dioscin, are used to treat coronary heart disease, coronary insufficiency, as well as control hyperlipidemia.

Pharmacology

Studies showed that compound preparations containing dioscin can increase coronary blood flow, reduce myocardial oxygen consumption, and protect myocardial ischemia and ischemia-reperfusion injury, which is beneficial for alleviating myocardial ischemia and angina. In addition, dioscin can regulate the lipid metabolism and improve hemodynamics. Dioscin can also prevent atherosclerosis by reducing serum total cholesterol, triglyceride, low-density lipoprotein, and oxidized lowdensity lipoprotein, reducing the whole blood viscosity and plasma viscosity at high and low shear rates, and relieving arterial wall lipid infiltration and plaque formation. Furthermore, dioscin can reduce liver fat deposition, which may be related to promoting cholesterol secretion metabolism.
It has also been reported that dioscin can induce the apoptosis of a variety of tumor cells, including gastric cancer cells, breast cancer cells, lung cancer cells, oral squamous cell carcinoma, and cervical cancer cells. The mechanisms are related to reducing the oxidative stress and inhibiting some cellular survival signaling pathways
Dioscin can induce antioxidant enzymes, lower blood lipids, improve insulin resistance, inhibit the inflammatory response, reduce the damage of alcoholic hepatitis, and decrease the hepatic injury induced by acetaminophen .

Dioscin Preparation Products And Raw materials

Raw materials

Preparation Products

Dehydroepiandrosterone

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View Lastest Price from Dioscin manufacturers

Hebei Shengyang Water Conservancy Engineering Co., Ltd.

Product: Dioscin 19057-60-4
Price: US $18.00-18.00/kg
Min. Order: 1kg
Purity: 99.9
Supply Ability: 5000
Release date: 2024-05-11

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Dioscin 19057-60-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-04

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Dioscin 19057-60-4
Price: US $200.00-85.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

19057-60-4, DioscinRelated Search:

Saponin POLYPHYLLIN B (RG) Chonglou Saponin II Matrine Esculin Icariin POLYPHYLLIN E (RG) Paris saponin V palmitate POLYPHYLLIN D Chonglou Saponin VII Polyphyllin VI Prosapogenin A 【dioscin】 27-Hydroxycholesterol PROTOGRACELLIN methyl protodioscin Diosgenin glucoside Diosgenin Protodioscin

DIOSCIN

beta-d-glucopyranoside,(3-beta,25r)-spirost-5-en-3-ylo-6-deoxy-alpha-l-mannop

Dioscin(Collettiside III)

Dioscin / Diosgenyl 2,4-Di-O-α-L-rhamnopyranosyl-β-D-glucopyranoside

collettisideiii

dioscine

yranosyl-(1-2)-o-(6-deoxy-alpha-l-mannopyranosyl)-(1-4))-

DIOSCIN(P)

β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-

(25R)-3β-[2-O,4-O-Bis(α-L-rhamnopyranosyl)-β-D-glucopyranosyloxy]spirosta-5-ene

[(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

[(25R)-Spirosta-5-ene-3β-yl]2-O,4-O-bis(α-L-rhamnopyranosyl)-β-D-glucopyranoside

[(25R)-Spirosta-5-ene-3β-yl]2-O,4-O-di-α-L-rhamnopyranosyl-β-D-glucopyranoside

beta-D-Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl o-6-deoxy-alpha-L-mannopyranosyl-(1-2)-o-(6-deoxy-alpha-L-mannopyranosyl-(1-4))-

Ccris 4123

Dioscin (6ci,7ci,8ci)

Diosgenin bis-alpha-L-rhamnopyranosyl)-(1-2 and 1-4)-beta-D-glucopyranoside

Dioscin, 98%, from Dioscorea opposita Thunb.

DIOSCIN(RG)

Dioscin 19057-60-4

Dioscin Green Plants Extracts 19057-60-4 Dioscorea Nipponica Source

COLLETTISIDE III; CCRIS 4123

Yam Extract Dioscin

ioscin

Dioscin USP/EP/BP

Dioscin (CCRIS 4123)

Polyphyllin lll

(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol)

19057-60-4

C45H72O16

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Miscellaneous Natural Products

Natural Plant Extract

The group of Dioscin