ChemicalBook > CAS DataBase List > 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE

3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE

Product Name: 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE
CAS No.: 79418-78-3
Chemical Name: 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE
Synonyms: 5-FLUOROVANILLIN;3-Fluoro-4-hydroxy-5-methoxybenzene;3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYD&;3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE;Benzaldehyde, 3-fluoro-4-hydroxy-5-methoxy-
CBNumber: CB2776570
Molecular Formula: C8H7FO3
Formula Weight: 170.14
MOL File: 79418-78-3.mol

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3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Property

Melting point:: 114-118 °C (lit.)
Boiling point:: 114-118℃
Density: 1.331±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.54±0.23(Predicted)
form: Powder
color: Yelloe to pale brown
Sensitive: Air Sensitive
InChI: InChI=1S/C8H7FO3/c1-12-7-3-5(4-10)2-6(9)8(7)11/h2-4,11H,1H3
InChIKey: OOGOFUKAJDPHDJ-UHFFFAOYSA-N
SMILES: C(=O)C1=CC(OC)=C(O)C(F)=C1
CAS DataBase Reference: 79418-78-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 526819
Product name: 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
Purity: 97%
Packaging: 1g
Price: $114
Updated: 2025/07/31

TRC

Product number: F591750
Product name: 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
Packaging: 1g
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021806
Product name: 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE
Purity: 95.00%
Packaging: 250MG
Price: $425
Updated: 2021/12/16

Matrix Scientific

Product number: 076959
Product name: 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
Purity: 98%
Packaging: 1g
Price: $99
Updated: 2021/12/16

Apolloscientific

Product number: PC0941
Product name: 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
Packaging: 1g
Price: $102
Updated: 2021/12/16

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3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde is a reagent in the synthesis of series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives.

Uses

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde may be used to synthesize 3-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N-phenethylacrylamide and 4-[(4-hydroxy-3-fluoro-5-methoxy-benzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one.

General Description

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde is an aryl fluorinated building block.

Synthesis

127685-76-1

79418-78-3

General procedure for the synthesis of 3-fluoro-4-hydroxy-5-methoxybenzaldehyde using 2-fluoro-6-methoxy-4-methylphenol as starting material: substrate 1a (1 mmol), cobalt salt (n1 mol%), and NaOH (n2 equivalents) were dissolved in ethylene glycol (5 mL) and the reaction was stirred for 8 hr at 80°C under oxygen (1 atm) atmosphere. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were sequentially added to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL × 2). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10/1) to give the target product 2a.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411
[2] Green Chemistry, 2014, vol. 16, # 5, p. 2807 - 2814
[3] Green Chemistry, 2014, vol. 16, # 3, p. 1248 - 1254

3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 79418-78-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-21

Career Henan Chemical Co

Product: 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 79418-78-3
Price: US $8.00/KG
Min. Order: 1g
Purity: ≥98%
Supply Ability: kg--tons
Release date: 2020-03-05

Career Henan Chemical Co

Product: 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 79418-78-3
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

79418-78-3, 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDERelated Search:

Homovanillic acid ISOEUGENOL 2-FLUORO-3-HYDROXY-4-METHOXYBENZALDEHYDE RARECHEM AL BI 0900 RARECHEM AL BF 0900 3-FLUOROCATECHOL Benzaldehyde, 3-fluoro-5-methoxy- (9CI) 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE RARECHEM AL BE 0900 2-FLUORO-6-METHOXYPHENOL

3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE

5-FLUOROVANILLIN

3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYD&

Benzaldehyde, 3-fluoro-4-hydroxy-5-methoxy-

3-Fluoro-4-hydroxy-5-methoxybenzene

79418-78-3

FC6H2OHOCH3CHO

Building Blocks

Carbonyl Compounds

Organic Building Blocks

Aldehydes

Fluorine series

Aldehydes

Carbonyl Compounds

Aromatic Aldehydes & Derivatives (substituted)