3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE
- Product Name
- 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE
- CAS No.
- 79418-78-3
- Chemical Name
- 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE
- Synonyms
- 5-FLUOROVANILLIN;3-Fluoro-4-hydroxy-5-methoxybenzene;3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYD&;3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE;Benzaldehyde, 3-fluoro-4-hydroxy-5-methoxy-
- CBNumber
- CB2776570
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 79418-78-3.mol
3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Property
- Melting point:
- 114-118 °C (lit.)
- Boiling point:
- 114-118℃
- Density
- 1.331±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.54±0.23(Predicted)
- form
- Powder
- color
- Yelloe to pale brown
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C8H7FO3/c1-12-7-3-5(4-10)2-6(9)8(7)11/h2-4,11H,1H3
- InChIKey
- OOGOFUKAJDPHDJ-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(OC)=C(O)C(F)=C1
- CAS DataBase Reference
- 79418-78-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 526819
- Product name
- 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- F591750
- Product name
- 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 092685
- Product name
- 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 076959
- Product name
- 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 076959
- Product name
- 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Fluoro-4-hydroxy-5-methoxybenzaldehyde is a reagent in the synthesis of series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives.
Uses
3-Fluoro-4-hydroxy-5-methoxybenzaldehyde may be used to synthesize 3-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N-phenethylacrylamide and 4-[(4-hydroxy-3-fluoro-5-methoxy-benzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one.
General Description
3-Fluoro-4-hydroxy-5-methoxybenzaldehyde is an aryl fluorinated building block.
Synthesis
127685-76-1
79418-78-3
General procedure for the synthesis of 3-fluoro-4-hydroxy-5-methoxybenzaldehyde using 2-fluoro-6-methoxy-4-methylphenol as starting material: substrate 1a (1 mmol), cobalt salt (n1 mol%), and NaOH (n2 equivalents) were dissolved in ethylene glycol (5 mL) and the reaction was stirred for 8 hr at 80°C under oxygen (1 atm) atmosphere. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were sequentially added to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL × 2). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10/1) to give the target product 2a.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411
[2] Green Chemistry, 2014, vol. 16, # 5, p. 2807 - 2814
[3] Green Chemistry, 2014, vol. 16, # 3, p. 1248 - 1254
3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE Suppliers
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- Switzerland
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View Lastest Price from 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE manufacturers
- Product
- 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 79418-78-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-21
- Product
- 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 79418-78-3
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- kg--tons
- Release date
- 2020-03-05
- Product
- 3-FLUORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 79418-78-3
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10