ChemicalBook > CAS DataBase List > Hydroxyzine dihydrochloride

Hydroxyzine dihydrochloride

Product Name
Hydroxyzine dihydrochloride
CAS No.
2192-20-3
Chemical Name
Hydroxyzine dihydrochloride
Synonyms
orgatrax;Hydroxyzine 2HCl;QYS;Quies;Disron;Durrax;Quiess;alamon;neurolax;(S)-Hydroxyzine
CBNumber
CB2777401
Molecular Formula
C21H29Cl3N2O2
Formula Weight
447.83
MOL File
2192-20-3.mol
More
Less

Hydroxyzine dihydrochloride Property

Melting point:
190-192°C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
powder
color 
White to Off-White
Water Solubility 
H2O: soluble
alcohol: soluble
chloroform: soluble
CAS DataBase Reference
2192-20-3(CAS DataBase Reference)
EPA Substance Registry System
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
KK2280000
HS Code 
29335990
Toxicity
LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1435000
Product name
Hydroxyzine hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
600 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
H-124
Product name
Hydroxyzine dihydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$130
Updated
2025/07/31
Sigma-Aldrich
Product number
BP841
Product name
Hydroxyzine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100 mg
Price
$234
Updated
2025/07/31
Sigma-Aldrich
Product number
1333003
Product name
Hydroxyzine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$425
Updated
2025/07/31
TCI Chemical
Product number
H1832
Product name
Hydroxyzine Dihydrochloride
Packaging
1G
Price
$36
Updated
2025/07/31
More
Less

Hydroxyzine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Atarax,UCB,France,1956

Uses

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Uses

Antihistaminic;H1 antogonist

Uses

Anti histamines

Uses

H1 receptor antagonist. Anxiolytic. Antihistaminic.

Manufacturing Process

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.

brand name

Amplimexon (Amplimed).

Therapeutic Function

Tranquilizer

General Description

Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Hydroxyzine dihydrochloride Preparation Products And Raw materials

Raw materials

Chlorodiphenylmethane 1-(2-(2-hydroxy ethoxy)ethyl)perazine

Preparation Products

More
Less

Hydroxyzine dihydrochloride Suppliers

Canada 1 China 215 India 24 South Korea 1 Switzerland 1 United Kingdom 3 United States 34 Global 279
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Eastar Chemical Corp
Tel
+86-024-25362369-8022 +8613998281317
Email
angelameng@chinaeastar.com
Country
United States
ProdList
376
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Wonda Science
Tel
--
Fax
--
Email
wonda@wondascience.com
Country
United States
ProdList
2192
Advantage
50
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
ACIC Fine Chemicals Inc.
Tel
--
Fax
--
Email
sales@acic.com
Country
United States
ProdList
492
Advantage
48
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
ECA International Corporation
Tel
--
Fax
--
Email
services@ecacorporation.com
Country
United States
ProdList
1062
Advantage
52
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
More
Less

View Lastest Price from Hydroxyzine dihydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Hydroxyzine dihydrochloride 2192-20-3
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-25
Baoji Guokang Healthchem Co., Ltd.
Product
Hydroxyzine dihydrochloride 2192-20-3
Price
US $1910.00/Kg/Bag
Min. Order
20KG
Purity
99%
Supply Ability
10T
Release date
2021-06-03
Shaanxi Dideu New Materials Co. Ltd
Product
Hydroxyzine dihydrochloride 2192-20-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-06

2192-20-3, Hydroxyzine dihydrochlorideRelated Search:

Cetirizine dihydrochloride Decloxizine Hydroxyzine 2-Ethoxyethanol Promethazine hydrochloride Ethyl vinyl ether Ethyl acetate Ethoxyquin ETHANOLAMINE HYDROCHLORIDE DIETHOXYMETHANE Hydroxydiethylphenamine Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- 1-(4-Chlorobenzhydryl)piperazine Hydroxylamine hydrochloride Dihydrochloride Levoceitrizine Hcl 1-[(2-Chlorophenyl)-N-(methylimino)methyl]cyclopentanol hydrochloride Decloxizin HCL CP2000

  • ateraxdihydrochloride
  • dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine
  • neurolax
  • orgatrax
  • tran-qdihydrochloride
  • Disron
  • Hydroxyzine Hydrochloride (500 mg)
  • Hydroxyzine Di Hcl
  • 2-(2-(4-((4-Chlorophenyl)(phenyl)Methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride
  • Hydroxyzine dihydroc
  • Ethanol,2-[2-[4-[(4-chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]-, hydrochloride(1:2)
  • Hydroxyzine 2HCl
  • Hydroxyzine dihydrochloride solution
  • HYDROXYZINE DIHYDROCHLORIDE
  • 2-[2-[4-[(4-chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
  • 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-ethanodihydroc
  • tranquizinedihydrochloride
  • vistarilsteraject
  • 2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride
  • Durrax
  • Quies
  • Ethanol, 2-2-4-(4-chlorophenyl)phenylmethyl-1-piperazinylethoxy-, dihydrochloride
  • HYDROXYZINEHYDROCHLORIDE,USP
  • 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine dihydrochloride
  • 2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol dihydrochloride
  • Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-, dihydrochloride (8CI)
  • Hydroxyzyne hydrochloride
  • Quiess
  • QYS
  • Vistaril Parenteral
  • 2-(2-(4-((4-CHLOROPHENYL)(PHENYL)METHYL)PIPERAZIN-1-YL)ETHOXY)ETHANOL 2HCL
  • 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanoldihydrochl
  • 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-ethanodihydro
  • alamon
  • ataraxdihydrochloride
  • ataraxoiddihydrochloride
  • Hydroxyzine hydrochloride CRS
  • Hydroxyzine dihydrochloride USP/EP/BP
  • 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin- 1-yl}ethoxy)ethan-1-ol dihydrochloride
  • Hydroxyzine DihydrochlorideQ: What is Hydroxyzine Dihydrochloride Q: What is the CAS Number of Hydroxyzine Dihydrochloride Q: What is the storage condition of Hydroxyzine Dihydrochloride Q: What are the applications of Hydroxyzine Dihydrochloride
  • Hydroxyzine hydrochloride(H1435000)
  • C21H29Cl3N2O2 Hydroxyzine dihydrochloride 2192-20-3
  • Hydroxyzine Hydrochloride (1333003)
  • 13-Tridecanedioic acid
  • Hydrochloric acid hydroxyl oxazine
  • (S)-Hydroxyzine
  • Hydroxyzine Dihydrochloride in Methanol
  • C14254000 HydroxyzinEDihydrochloride
  • Hydroxyzine dihydrochloride, 10 mM in DMSO
  • Abmole M2760-200mg Hydroxyzine dihydrochloride 2192-20-3
  • Hydroxyzine Hydrochloride 1.0 mg/ml in Methanol (as free base)
  • Hydroxyzine.2HCl, 1mg/ml in Methanol (as free base)
  • 2192-20-3
  • 2092-20-3
  • C21H27ClN2O22ClH
  • C21H27ClN2O22HCl
  • C21H29Cl3N2O2
  • Enzymes, Inhibitors, and Substrates