ChemicalBook > CAS DataBase List > Hydroxyzine dihydrochloride

Hydroxyzine dihydrochloride

Product Name
Hydroxyzine dihydrochloride
CAS No.
2192-20-3
Chemical Name
Hydroxyzine dihydrochloride
Synonyms
orgatrax;Hydroxyzine 2HCl;QYS;Quies;Disron;Durrax;Quiess;alamon;neurolax;(S)-Hydroxyzine
CBNumber
CB2777401
Molecular Formula
C21H29Cl3N2O2
Formula Weight
447.83
MOL File
2192-20-3.mol
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Hydroxyzine dihydrochloride Property

Melting point:
190-192°C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
powder
color 
White to Off-White
CAS DataBase Reference
2192-20-3(CAS DataBase Reference)
EPA Substance Registry System
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
KK2280000
HS Code 
29335990
Toxicity
LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H336May cause drowsiness or dizziness

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H-124
Product name
Hydroxyzine dihydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
1333003
Product name
Hydroxyzine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1607
Product name
Hydroxyzine dihydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
H8885
Product name
Hydroxyzine dihydrochloride
Purity
≥98%
Packaging
10g
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
H1435000
Product name
Hydroxyzine hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
h1435000
Price
$153
Updated
2024/03/01
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Hydroxyzine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Atarax,UCB,France,1956

Uses

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Uses

Antihistaminic;H1 antogonist

Uses

Anti histamines

Uses

H1 receptor antagonist. Anxiolytic. Antihistaminic.

Manufacturing Process

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.

brand name

Amplimexon (Amplimed).

Therapeutic Function

Tranquilizer

General Description

Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Hydroxyzine dihydrochloride Preparation Products And Raw materials

Raw materials

Chlorodiphenylmethane 1-(2-(2-hydroxy ethoxy)ethyl)perazine

Preparation Products

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View Lastest Price from Hydroxyzine dihydrochloride manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Hydroxyzine dihydrochloride 2192-20-3
Price
US $1910.00/Kg/Bag
Min. Order
20KG
Purity
99%
Supply Ability
10T
Release date
2021-06-03
Hebei Weibang Biotechnology Co., Ltd
Product
Hydroxyzine dihydrochloride 2192-20-3
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-25
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
Hydroxyzine dihydrochloride 2192-20-3
Price
US $25.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
5000kg/month
Release date
2022-01-12

2192-20-3, Hydroxyzine dihydrochlorideRelated Search:

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