ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE
- Product Name
- ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE
- CAS No.
- 77112-52-8
- Chemical Name
- ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE
- Synonyms
- WCIUYUMPQYSUSD-GBCQHVBFSA-N;ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE;2-imidazo[1,2-a]pyrazinecarboxylic acid ethyl ester;IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID ETHYL ESTER;Imidazo[1,2-a]pyrazine-2-carboxylic acid, ethyl ester (9CI, ACI)
- CBNumber
- CB2778796
- Molecular Formula
- C9H9N3O2
- Formula Weight
- 191.19
- MOL File
- 77112-52-8.mol
ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE Property
- Melting point:
- 175-177 °C(Solv: ethanol (64-17-5))
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.78±0.30(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C9H9N3O2/c1-2-14-9(13)7-6-12-4-3-10-5-8(12)11-7/h3-6H,2H2,1H3
- InChIKey
- SWABYVXORFBBAT-UHFFFAOYSA-N
- SMILES
- C12=NC(C(OCC)=O)=CN1C=CN=C2
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E919210
- Product name
- Ethylimidazo[1,2-a]pyrazine-2-carboxylate
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- J56291
- Product name
- EthylImidazo[1,2-a]pyrazine-2-carboxylate
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- X0340
- Product name
- EthylImidazo[1,2-a]pyrazine-2-carboxylate
- Packaging
- 250mg
- Price
- $54
- Updated
- 2021/12/16
- Product number
- J56291
- Product name
- EthylImidazo[1,2-a]pyrazine-2-carboxylate
- Packaging
- 5g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 057561
- Product name
- Ethyl imidazo[1,2-a]pyrazine-2-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $550
- Updated
- 2021/12/16
ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
5049-61-6
70-23-5
77112-52-8
Method A-Oxide To a stirred dimethoxyethane solution of 2-aminopyrazine (1.0 g, 10.5 mmol) was added dropwise ethyl 3-bromopyruvate (2.36 g, 13.0 mmol) at room temperature and the reaction mixture was continued to stir for 2.5 hours at room temperature. Subsequently, the reaction mixture was cooled to 0 °C and maintained at this temperature with stirring for 30 min, during which a light brown precipitate was generated. The precipitate was collected by filtration and washed with ethyl acetate to give a light brown solid. The solid was suspended in 50 mL of ethanol and heated to reflux temperature until a clarified solution was formed. After refluxing the reaction for 2 hours, the reaction mixture was concentrated under reduced pressure. The concentrate was subsequently treated with a mixture of CH2Cl2 and saturated aqueous NaHCO3. The mixture was filtered through a diatomaceous earth pad, the organic layer was separated and dried with anhydrous Na2SO4 and filtered to remove the desiccant. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with CH2Cl2:MeOH (99:1 to 97:3, v/v) as eluent. The target fraction was collected and concentrated under reduced pressure to afford ethyl imidazo[1,2-a]pyrazine-2-carboxylate as light yellow crystals (0.546 g, 27% yield).1H NMR (400 MHz, CDCl3) δ 9.21 (s, 1H), 8.26 (s, 1H), 8.09 (dd, J = 4.7,1.6 Hz, 1H), 7.96 (d, J = 4.7 Hz, 1H), 4.49 (q, J=7.1 Hz, 2H), 1.45 (t, J=7.1 Hz, 3H).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[2] Farmaco, Edizione Scientifica, 1981, vol. 36, # 1, p. 61 - 80
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 10, p. 2300 - 2304
[4] Patent: WO2014/113191, 2014, A1. Location in patent: Paragraph 0077; 0078
[5] European Journal of Medicinal Chemistry, 1983, vol. 18, # 5, p. 413 - 417
ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE Suppliers
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View Lastest Price from ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE manufacturers
- Product
- ethyl imidazo[1,2-a]pyrazine-2-carboxylate 77112-52-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE 77112-52-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19