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L(+)-Leucinol

Product Name
L(+)-Leucinol
CAS No.
7533-40-6
Chemical Name
L(+)-Leucinol
Synonyms
L-LEUCINOL;(S)-2-amino-4-methylpentan-1-ol;(S)-LEUCINOL;(+)-L;Leu-ol;eucinoL;H-LEU-OL;L-Leu-ol;H-LEUCINOL;H-L-LEU-OL
CBNumber
CB2781730
Molecular Formula
C6H15NO
Formula Weight
117.19
MOL File
7533-40-6.mol
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L(+)-Leucinol Property

Melting point:
56-58 °C
Boiling point:
208-210 °C(lit.)
alpha 
3 º (589nm, c=9, ethanol)
Density 
0.917 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4511(lit.)
Flash point:
195 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
12.88±0.10(Predicted)
form 
Liquid
Specific Gravity
0.917
color 
Clear colorless to slightly yellow light
optical activity
[α]20/D +4°, c = 9 in ethanol
Sensitive 
Air Sensitive
BRN 
1719240
CAS DataBase Reference
7533-40-6(CAS DataBase Reference)
NIST Chemistry Reference
1-Pentanol, 2-amino-4-methyl-, (S)-(7533-40-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37/39-27
WGK Germany 
3
F 
2-10
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

TCI Chemical
Product number
L0137
Product name
L-(+)-Leucinol
Purity
>97.0%(GC)(T)
Packaging
5mL
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
L0137
Product name
L-(+)-Leucinol
Purity
>97.0%(GC)(T)
Packaging
25mL
Price
$122
Updated
2025/07/31
Usbiological
Product number
281414
Product name
L-Leucinol
Packaging
10g
Price
$363
Updated
2021/12/16
TRC
Product number
A634360
Product name
(S)-2-Amino-4-methylpentanol
Packaging
25g
Price
$325
Updated
2021/12/16
ChemPep
Product number
201201
Product name
L-Leucinol
Purity
≥98%
Packaging
25g
Price
$433
Updated
2021/12/16
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L(+)-Leucinol Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow

Uses

Starting material for the synthesis of aminopeptidase N and phospholipase A2 inhibitors.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

7517-19-3

7533-40-6

The general procedure for the synthesis of (S)-2-amino-4-methylpentan-1-ol from L-leucine methyl ester hydrochloride was as follows: to a mixture of EtOH (1.8 L) containing L-leucine methyl ester hydrochloride (254 g, 1.4 mol), NaHCO3 (118 g, 1.4 mol, 1.0 eq.), and water (1.8 L) at 5°C, batchwise addition of NaBH4 (159 g, 4.2 mol, 3.0 eq.) at a rate commensurate with the reaction temperature, maintaining the reaction temperature at no more than 15°C (ca. 70 min.) After the addition of NaBH4 was complete, the ice bath was removed, and the reaction mixture was heated to reflux temperature and held overnight. Upon completion of the reaction, the mixture was cooled to room temperature. The resulting slurry was filtered with the aid of an ice bath and the solids were washed with EtOH (750 mL). The filtrates were combined and concentrated under reduced pressure to about 950 mL. the residue was diluted with EtOAc (2.5 L) and subsequently extracted with 1N NaOH solution (2 x 1 L). The aqueous layer was back-extracted with EtOAc (2 x 750mL). The organic phases were combined, dried over MgSO4 and concentrated under reduced pressure to afford (S)-1-(hydroxymethyl)-3-methylbutylamine as a light yellow oil (112 g, 65% yield). The product was characterized by 1H NMR (CDCl3): δ 0.88-0.93 (m, 6H), 1.17 (t, J = 7.7 Hz, 2H), 1.68-1.80 (m, 2H), 1.82 (br s, 2H), 2.86-2.91 (m, 1H), 3.22 (dd, J = 10.7,8.1 Hz, 1H), 3.56 ( dd, J = 10.3,3.6 Hz, 1H).

References

[1] Patent: US6353006, 2002, B1. Location in patent: Page column 31

L(+)-Leucinol Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Lithium Aluminum Hydride L-Leucine

Preparation Products

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L(+)-Leucinol Suppliers

Americas 1 Austria 1 Belgium 2 Canada 1 China 241 Europe 3 France 2 Germany 8 India 19 Japan 6 Slovakia 1 Switzerland 6 United Kingdom 11 United States 59 Global 361
Interchim SA
Tel
--
Fax
--
Email
him@interchim.com
Country
France
ProdList
2725
Advantage
58
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from L(+)-Leucinol manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
L(+)-Leucinol 7533-40-6
Price
US $0.00-0.00/G
Min. Order
1G
Purity
99%
Supply Ability
2000
Release date
2025-10-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L(+)-Leucinol 7533-40-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
50kg/month
Release date
2023-01-09
Hebei Chuanghai Biotechnology Co., Ltd
Product
L(+)-Leucinol 7533-40-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-21

7533-40-6, L(+)-LeucinolRelated Search:

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  • 2-AMINO-4-METHYL-1-PENTANOL
  • (2S)-2-AMINO-4-METHYLPENTAN-1-OL
  • (S)-(+)-2-AMINO-4-METHYL-1-PENTANOL
  • (S)-2-AMINO-4-METHYL-1-PENTANOL
  • (S)-(+)-LEUCINOL
  • (S)-LEUCINOL
  • H-LEU-OL
  • (S)-(+)-Leucinol 96%
  • L-Leucinol hydrochloride AldrichCPR
  • Leu-ol
  • L-Leucinol,99%e.e.
  • [(2S)-1-hydroxy-4-methylpentan-2-yl]ammonium
  • eucinoL
  • H-LEUCINOL
  • H-L-LEU-OL
  • L-(+)-LEUCINOL
  • L-LEUCINOL
  • L-Leu-ol
  • (S)-2-Amino-4-methylpentanol~H-Leu-ol
  • L-Leucinol,97%
  • (S)-2-Amino-4-methylpentanol
  • (S)-2-amino-4-methylpentan-1-ol
  • L-LEUCINOL / (S)-(+)-2-AMINO-4-METHYL-1-PENTANOL
  • (S)-(+)-LEUCINOL ((S)-(+)-2-AMINO-4-METHYL-1-PENTANOL)
  • 1-PENTANOL, 2-AMINO-4-METHYL-, (2S)-
  • (S)-2-Amino-4-methyl-1-pentanol, 2-Amino-4-methyl-1-pentanol, L-Leucinol
  • 1-Pentanol, 2-amino-4-methyl-, (S)-
  • (2S)-2-Amino-4-methyl-1-pentanol
  • L(+)-Leucinol,98%
  • L(+)-Leucinol, 98% 5GR
  • (S)-(+)-Leucinol,(S)-2-Amino-4-methyl-1-pentanol, 2-Amino-4-methyl-1-pentanol, L-Leucinol
  • 2(S)-AMino-4-Methylpentan-1-ol
  • L-Leucinol, (2S)-(+)-Leucinol
  • (2S)-2-Amino-4-methylpentan-1-ol 97%
  • L-(+)-Leucinol&gt
  • H-Leucinol (oil)
  • (+)-L
  • L(+)-Leucinol USP/EP/BP
  • L-(+)-Leucinol,96%
  • L(+)-Leucinol, 10 mM in DMSO
  • (<i>S</i>)-(+)-Leucinol
  • 7533-40-6
  • CH32CHCH2CHNH2CH2OH
  • AMINE
  • Chiral Building Blocks
  • Amino Alcohols (Chiral)
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Alcohols
  • Amino Acid Derivatives
  • Leucine [Leu, L]
  • Amino Alcohols
  • Amino Alcohols (Chiral)
  • Chiral Building Blocks
  • Synthetic Organic Chemistry
  • Chiral Compound
  • Amino alcohols
  • Pharmaceutical Intermediates