ChemicalBook > CAS DataBase List > Diphenylacetonitrile

Diphenylacetonitrile

Product Name
Diphenylacetonitrile
CAS No.
86-29-3
Chemical Name
Diphenylacetonitrile
Synonyms
DIPAN;DPAN;dibenzylcyanide;-Cyanodiphenylmethane;Acetonitrile, diphenyl-;alpha-Cyanodiphenylmethane;Benzeneacetonitrile, α-phenyl-;alpha-phenylbenzeneacetonitrile;usafkf-13;USAF kf-13
CBNumber
CB2782757
Molecular Formula
C14H11N
Formula Weight
193.25
MOL File
86-29-3.mol
More
Less

Diphenylacetonitrile Property

Melting point:
71-73 °C (lit.)
Boiling point:
181 °C/12 mmHg (lit.)
Density 
1.1061 (rough estimate)
vapor pressure 
21.3 hPa (190 °C)
refractive index 
1.5850 (estimate)
Flash point:
120 °C
storage temp. 
Store below +30°C.
solubility 
INSOLUBLE
form 
Crystalline Powder
color 
White to creamy or faint yellow
Water Solubility 
INSOLUBLE
Merck 
14,3316
BRN 
1911160
Exposure limits
NIOSH: IDLH 25 mg/m3
InChIKey
NEBPTMCRLHKPOB-UHFFFAOYSA-N
LogP
2.795-3.197 at 25℃
CAS DataBase Reference
86-29-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetonitrile, «alpha»-phenyl-(86-29-3)
EPA Substance Registry System
Diphenylacetonitrile (86-29-3)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
2
RTECS 
AL9800000
TSCA 
Yes
HS Code 
29269095
Toxicity
LD50 orally in Rabbit: 3500 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.03259
Product name
Diphenylacetonitrile
Purity
for synthesis
Packaging
100g
Price
$11.5
Updated
2024/03/01
Sigma-Aldrich
Product number
112127
Product name
Diphenylacetonitrile
Purity
98%
Packaging
500g
Price
$24.8
Updated
2024/03/01
Sigma-Aldrich
Product number
112127
Product name
Diphenylacetonitrile
Purity
98%
Packaging
100g
Price
$44.6
Updated
2024/03/01
TCI Chemical
Product number
D0261
Product name
Diphenylacetonitrile
Purity
>99.0%(GC)
Packaging
25g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
D0261
Product name
Diphenylacetonitrile
Purity
>99.0%(GC)
Packaging
500g
Price
$139
Updated
2024/03/01
More
Less

Diphenylacetonitrile Chemical Properties,Usage,Production

Chemical Properties

Diphenylacetonitrile is a white to creamy or faint yellow crystalline powder, Soluble in ethanol, ether. It is obtained by bromination and condensation of phenylacetonitrile. Diphenylacetonitrile is mainly used as an intermediate to manufacture API which deals in treatment of respiratory stimulant. It is used to manufacture APIs like stomach amine, Aminepentamide Sulphate, Diphenoxylate, Diphenylacetaldehyde, Doxapram, Loperamide, Methadone.

Uses

Mathadone (M225865) impurity. Used in synthesis of methadone, antispasmodics and other pharmaceuticals.
Diphenylacetonitrile is used to synthesize isocyanate, which is further prepared into UV paint, PU paint, transparent elastomer and adhesive, etc. In addition, it is also used in polyamide and epoxy resin industries.

Preparation

Diphenylacetonitrile can be prepared in good yield by the dehydration of the amide of diphenyl acetic acid with phosphorous oxychloride. Diphenylacetonitrile undergoes anhydrous condensation with ethyl-4-bromo-butyrate. This is followed by its hydrolysis in alkaline medium that is used in the quantitative determination of 3-cyano-3,3-diphenylpropionic acid.

Preparation

In a 100 mL, nitrogen-flushed pear flask was added indium(III) bromide (2.0 mmol, 10 mol %) in CH2Cl2 (40 mL) to give a white suspension. To this at room temperature was added trimethylsilyl cyanide (40 mmol, 2.0 equiv.), followed by dropwise addition of alcohol (20 mmol, 1.0 equiv.) to give a moderate exothermic reaction. The mixture slowly turned clear, and TLC showed mostly the desire product. Saturated NaHCO3 was added and the mixture was concentrated in vacuo to remove the volatiles. The residue was partitioned between saturated NaHCO3 and ethyl acetate, and the aqueous layer was extracted one more time with ethyl acetate. Combined organic layers were dried over MgSO4, filtered and concentrated. The crude product was purified by flash column chromatography on silica gel (5% ethyl acetate/hexanes) to give the desired Diphenylacetonitrile.

Reactions

Methadone is synthesised by alkylation of diphenylacetonitrile using 2-dimethylaminopropylchloride in the presence of sodamide.
Dextromoramide is synthesised by alkylation of diphenylacetonitrile using 1-morpholinyl-2- chloropropane in the presence of sodamide.
Diphenylacetonitrile in the presence of sodium amide is alkylated with 1-ethyl-3-chlorpyrrolidine, giving (1-ethyl-3-pyrrolidinyl) diphenylacetonitrile.
Isopropamide, is synthesized by alkylating diphenylacetonitrile with di-isopropylaminoethylchloride in the presence of sodium amide, and the subsequent hydrolysis of the nitrile group of the resulting compound to an amide group.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 3253, 1970 DOI: 10.1021/jo00835a016

General Description

Diphenylacetonitrile can be prepared in good yield by the dehydration of the amide of diphenyl acetic acid with phosphorous oxychloride.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NOx, and CN-. See also NITRILES.

Synthesis

Add the 250mL ethyl acetate in 500mL glass there-necked flask, open and stir, add the 150g phenylcarbinol, add sodium methylate 80g, 70 ℃ of stirring reactions 2 hours are down to room temperature, add benzyl cyanide 120ml.Be heated to 110 ℃, distillation reaction 10h.Reaction naturally cools to room temperature after finishing, and adds the extraction of 200ml ethyl acetate and 200ml water, tells lower aqueous layer.The upper strata ethyl acetate layer adds water, and washing once adds anhydrous sodium sulfate drying.Concentrating under reduced pressure is removed ethyl acetate.Then in oily matter, add a small amount of dehydrated alcohol crystallisation by cooling, the crystallized product oven dry.Yield 90%, purity 99.0% (GC).

Purification Methods

Crystallise the nitrile from EtOH or pet ether (b 90-100o). [Beilstein 9 H 674, 9 IV 2505.]

More
Less

Diphenylacetonitrile Suppliers

Changsha Changtang Import and Export Co., LTD
Tel
15364011506 15388971408
Fax
0731-84372366
Email
3182628472@qq.com
Country
China
ProdList
1003
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1218
Advantage
58
Hubei Baidu Chemical Co., Ltd
Tel
027-59106051 13627137652
Fax
027-59223020
Email
1438180055@qq.com
Country
China
ProdList
9969
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82375886 13001715031
Fax
0531-82375893
Email
3517280075@qq.com
Country
China
ProdList
1274
Advantage
58
Jiangsu Aifa Technology Co., Ltd
Tel
0519-89892883
Email
jsafkj@126.com
Country
China
ProdList
11
Advantage
58
NINGBO JL NEW MATERIAL CO.,LTD
Tel
0574-88552218 18969899212
Email
sales@jlbio-tech.cn
Country
China
ProdList
715
Advantage
58
Changzhou Luowan Biological Technology Co., Ltd.
Tel
13646143635
Email
617837247@qq.com
Country
China
ProdList
144
Advantage
58
Hubei Hongfuda Biotechnology Co., Ltd.
Tel
191-07255884 19107255884
Email
259506217@qq.com
Country
China
ProdList
1500
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9414
Advantage
66
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Syntor Fine Chemicals Ltd.
Tel
+44 (0) 1928 579865
Fax
0411-9285798
Email
sales@syntor.co.uk
Country
China
ProdList
78
Advantage
60
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ:3470079902
Email
675141927@qq.com
Country
China
ProdList
3203
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
TaiZhou ZhiCheng Chemicals & Technology Co., LTD.
Tel
0523-82837785 13914525028
Fax
0523-87913272
Email
info@jszchg.com
Country
China
ProdList
248
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2876
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
684
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq:2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
More
Less

View Lastest Price from Diphenylacetonitrile manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Diphenylacetonitrile 86-29-3
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
99%min
Supply Ability
20tons/month
Release date
2021-06-07
Dorne Chemical Technology co. LTD
Product
Diphenylacetonitrile 86-29-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000kg
Release date
2024-03-26
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Diphenylacetonitrile 86-29-3
Price
US $85.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-21

86-29-3, DiphenylacetonitrileRelated Search:


  • dibenzylcyanide
  • Difenylacetonitril
  • diphenyl-acetonitril
  • Diphenyl-alpha-cyanomethane
  • USAF kf-13
  • usafkf-13
  • Benzeneacetonitrile, alpha-phenyl-
  • DIPHENYLACETONITRILE PESTANAL, 250 MG
  • α-Phenylbenzyl cyanide
  • Diphenylacetonitrile, 99+%
  • diphenatrile/dipan
  • DIPHENYLACETONITRILE pure
  • BENZENEACETONITRILE,.ALPHA.-P
  • DIPHENYLMETHYL CYANIDE
  • DIPHENYLACETONITRILE
  • DIPHENYL-A-CYANOMETHANE
  • DIPHENATRILE
  • DIPAN
  • BENZHYDRYL CYANIDE
  • RARECHEM AQ A3 0160
  • Acetonitrile, diphenyl-
  • alpha-Cyanodiphenylmethane
  • alpha-phenyl-benzeneacetonitril
  • alpha-phenylbenzeneacetonitrile
  • alpha-Phenyl-benzeneacetonitrile
  • alpha-Phenylbenzylcyanide
  • alpha-Phenylphenylacetonitrile
  • a-Phenylbenzyl cyanide
  • a-Phenylphenylacetonitrile
  • Benzyhydrylcyanide
  • -Cyanodiphenylmethane
  • Diphenylacetomitrile
  • Diphenylacetonitrile, 99+% 100GR
  • Diphenylacetonitrile, 99+% 5GR
  • a-Phenylbenzeneacetonitrile
  • Diphenylaceton
  • Diphenylacetonitrile 99.5%min
  • Diphenylacetonitri
  • Diphenylacetonitrile≥ 99% (GC)
  • Diphenylacetonitrile &gt
  • Darifenacin Impurity 3 (Methadone EP Impurity E)
  • Benzeneacetonitrile, α-phenyl-
  • Methadone Hydrochloride Impurity 5(Methadone Hydrochloride EP Impurity E)
  • DPAN
  • Hot sale Diphenylacetonitrile CAS 86-29-3 with factory supply
  • Diphenylacetonitrile powder
  • Isopropyl myristate 110-27-0
  • Methadone Hydrochloride EP Impurity E
  • Methadone Hydrochloride Impurity E
  • 2,2-diphenylacetonitrile
  • 1-DIPHENYL ACETONITRILE
  • 4-[5-(2,3,5,6-tetradeuterio-4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
  • Diphenylacetonitrile Solution in Methanol
  • 86-29-3
  • C6H52CHCN
  • Cyanides/Nitriles
  • Organic Building Blocks
  • Nitrogen Compounds