ChemicalBook > CAS DataBase List > Dalbavancin hydrochloride

Dalbavancin hydrochloride

Product Name
Dalbavancin hydrochloride
CAS No.
2227366-51-8
Chemical Name
Dalbavancin hydrochloride
Synonyms
BI-397 hydrochloride;MDL-63397 hydrochloride;Dalbavancin Hydrochloride(Mixture);Ristomycin A,aglycone, 5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-o-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-o-α-D-mannopyranosyl-N15-methyl-, hydrochloride (1:1)
CBNumber
CB28029346
Molecular Formula
C88H101Cl3N10O28
Formula Weight
1853.17
MOL File
2227366-51-8.mol
More
Less

Dalbavancin hydrochloride Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO: ≥ 24 mg/mL (12.95 mM)
form 
Solid
color 
White to light yellow
Water Solubility 
Water: 50 mg/mL (26.98 mM)
InChIKey
PEXPCJWLNBNBNT-HHJXNUJUNA-N
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-3579
Product name
Dalbavancinhydrochloride
Purity
99.48%
Packaging
1mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-3579
Product name
Dalbavancinhydrochloride
Purity
99.48%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-3579
Product name
Dalbavancinhydrochloride
Purity
99.48%
Packaging
10mg
Price
$288
Updated
2021/12/16
ChemScene
Product number
CS-3579
Product name
Dalbavancinhydrochloride
Purity
99.48%
Packaging
25mg
Price
$528
Updated
2021/12/16
ChemScene
Product number
CS-3579
Product name
Dalbavancinhydrochloride
Purity
99.48%
Packaging
50mg
Price
$720
Updated
2021/12/16
More
Less

Dalbavancin hydrochloride Chemical Properties,Usage,Production

Uses

Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].

Biological Activity

Dalbavancin hydrochloride(MDL-63397 hydrochloride) is a semi-synthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90 of 0.06 μg/mL and 0.25 μg/mL, respectively.

in vitro

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA ), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.

in vivo

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.

Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B . anthracis
Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection ; every 36 h or 72 h; for 14 days
Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.

IC 50

Glycopeptide

References

[1] Heine HS, et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54(3):991-6. DOI:10.1128/AAC.00820-09
[2] Bennett JW, et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4(1):31-40. DOI:10.2147/tcrm.s46

Dalbavancin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Dalbavancin hydrochloride Suppliers

China 62 India 1 United States 4 Global 67
Tel
021-021-52919136 17315815539
Email
2804155403@qq.com
Country
China
ProdList
180
Advantage
58
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Tel
18622939839
Fax
QQ:343281693
Email
tjby921@163.com
Country
China
ProdList
884
Advantage
55
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Tel
18301977208
Fax
qq2126935757
Email
2126935757@qq.com
Country
China
ProdList
214
Advantage
55
Tel
027-83778895 18602735115
Fax
027-51119224
Email
18602735115@163.com
Country
China
ProdList
2005
Advantage
64
Tel
021-54285032 18116461626
Fax
021-54285032
Email
25493162@qq.com
Country
China
ProdList
148
Advantage
58
Tel
020-82000279 18988941452
Fax
QQ：3283937693
Email
YN_research@163.com
Country
China
ProdList
3011
Advantage
58
Tel
650-6922368
Email
sales@achemblock.com
Country
China
ProdList
2992
Advantage
58
Tel
15871722230
Fax
2796190295
Email
15871722230@163.com
Country
China
ProdList
4686
Advantage
58
Tel
027-61907345 13397111514
Fax
3443707954
Email
w13397111514@163.com
Country
China
ProdList
1005
Advantage
58
Tel
400-880-2824 18107960669
Fax
18140514863
Email
79046690@qq.com
Country
China
ProdList
1242
Advantage
58
Tel
027-59207852 13308628970
Fax
QQ:2779667926
Email
buy@fortunachem.com
Country
China
ProdList
2666
Advantage
58
Tel
400-880-2824; 13184580281
Fax
400-880-2824
Email
hj@ruiweier.cn
Country
China
ProdList
2686
Advantage
58
Tel
18502762009
Email
721846333@qq.com
Country
China
ProdList
2172
Advantage
58
Tel
027-81302411 15377658509
Email
zs@dkybpc.com
Country
China
ProdList
1982
Advantage
58
Tel
027-59102966 18717199209
Fax
027-59379337
Email
2853877583@qq.com
Country
China
ProdList
2715
Advantage
58
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Tel
400-880-2824 15608648206
Email
1987516016@qq.com
Country
China
ProdList
2671
Advantage
58
Tel
133-3998-5473 13339985473
Email
C13339985473@163.com
Country
China
ProdList
4991
Advantage
58
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Tel
4001650900 13817534909
Email
3003940895@qq.com
Country
China
ProdList
10714
Advantage
58
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5002
Advantage
58
Tel
4001-009266 17349750668
Email
product@sci-e.com
Country
China
ProdList
2808
Advantage
58
Tel
0512-65974739-0 15151475053
Email
mengqi_biopole@163.com
Country
China
ProdList
66
Advantage
58
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Tel
19359985961
Email
2430503320@qq.com
Country
China
ProdList
1452
Advantage
58
Tel
17721492509; 17721492509
Email
643638326@qq.com
Country
China
ProdList
4970
Advantage
58
Tel
0731-13823398 15111215862
Email
313359644@qq.com
Country
China
ProdList
4161
Advantage
58
Tel
19526384105
Email
3671394075@qq.com
Country
China
ProdList
2864
Advantage
58
Tel
027-59102966 18717199209
Email
2853877583@QQ.com
Country
China
ProdList
7499
Advantage
58
Tel
027-59101766 13125137661
Email
2853877621@qq.com
Country
China
ProdList
7979
Advantage
58
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Tel
020-81960175-877 18933936954
Email
2853283383@qq.com
Country
China
ProdList
11421
Advantage
58
Tel
028-81700200 13308200041
Email
2851167782@qq.com
Country
China
ProdList
11146
Advantage
58
Tel
0745-2866551 19976851779
Email
3002713163@qq.com
Country
China
ProdList
7333
Advantage
58
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Tel
400-668-6834
Email
info@selleck.cn
Country
China
ProdList
6071
Advantage
58
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
Tel
+86-0533-2185556 +8615965530500
Email
nickzhang@hangyubiotech.com
Country
China
ProdList
8510
Advantage
58
Tel
+undefined86-15223382610
Email
info@jooe.com
Country
China
ProdList
6208
Advantage
58
Tel
+86-18062099985
Email
Amyjiyunzen@yeah.net
Country
China
ProdList
672
Advantage
58
More
Less

View Lastest Price from Dalbavancin hydrochloride manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
Dalbavancin hydrochloride 2227366-51-8
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-29
Shaanxi Dideu New Materials Co. Ltd
Product
Dalbavancin hydrochloride 2227366-51-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-16

2227366-51-8, Dalbavancin hydrochlorideRelated Search:

Antibiotic A 40926 DesvancosaMinyl VancoMycin Teicoplanin A2-4 Teicoplanin A2-5 A 40926 coMplex

  • BI-397 hydrochloride
  • MDL-63397 hydrochloride
  • Dalbavancin Hydrochloride(Mixture)
  • Ristomycin A,aglycone, 5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-o-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-o-α-D-mannopyranosyl-N15-methyl-, hydrochloride (1:1)
  • 2227366-51-8
  • C88H101Cl3N10O28