Dalbavancin hydrochloride

Product Name: Dalbavancin hydrochloride
CAS No.: 2227366-51-8
Chemical Name: Dalbavancin hydrochloride
Synonyms: BI-397 hydrochloride;MDL-63397 hydrochloride;Dalbavancin Hydrochloride(Mixture);Ristomycin A,aglycone, 5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-o-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-o-α-D-mannopyranosyl-N15-methyl-, hydrochloride (1:1)
CBNumber: CB28029346
Molecular Formula: C88H101Cl3N10O28
Formula Weight: 1853.17
MOL File: 2227366-51-8.mol

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Dalbavancin hydrochloride Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: ≥ 24 mg/mL (12.95 mM)
form: Solid
color: White to light yellow
Water Solubility: Water: 50 mg/mL (26.98 mM)
InChIKey: PEXPCJWLNBNBNT-HHJXNUJUNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3579
Product name: Dalbavancinhydrochloride
Purity: 99.48%
Packaging: 1mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-3579
Product name: Dalbavancinhydrochloride
Purity: 99.48%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-3579
Product name: Dalbavancinhydrochloride
Purity: 99.48%
Packaging: 10mg
Price: $288
Updated: 2021/12/16

ChemScene

Product number: CS-3579
Product name: Dalbavancinhydrochloride
Purity: 99.48%
Packaging: 25mg
Price: $528
Updated: 2021/12/16

ChemScene

Product number: CS-3579
Product name: Dalbavancinhydrochloride
Purity: 99.48%
Packaging: 50mg
Price: $720
Updated: 2021/12/16

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Dalbavancin hydrochloride Chemical Properties,Usage,Production

Uses

Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].

Biological Activity

Dalbavancin hydrochloride(MDL-63397 hydrochloride) is a semi-synthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90 of 0.06 μg/mL and 0.25 μg/mL, respectively.

in vitro

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA ), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.

in vivo

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.

Animal Model:	Female BALB/c mice (6-8 weeks) challenged with Ames strain of B . anthracis
Dosage:	15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration:	Intraperitoneal injection ; every 36 h or 72 h; for 14 days
Result:	The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.

IC 50

Glycopeptide

References

[1] Heine HS, et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54(3):991-6. DOI:10.1128/AAC.00820-09
[2] Bennett JW, et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4(1):31-40. DOI:10.2147/tcrm.s46

Dalbavancin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Dalbavancin hydrochloride Suppliers

China 62 India 1 United States 4 Global 67

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View Lastest Price from Dalbavancin hydrochloride manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Dalbavancin hydrochloride 2227366-51-8
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-29

Shaanxi Dideu New Materials Co. Ltd

Product: Dalbavancin hydrochloride 2227366-51-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-16

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BI-397 hydrochloride

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Dalbavancin Hydrochloride(Mixture)

Ristomycin A,aglycone, 5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-o-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-β-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-o-α-D-mannopyranosyl-N15-methyl-, hydrochloride (1:1)

2227366-51-8

C88H101Cl3N10O28