Dalbavancin hydrochloride
- Product Name
- Dalbavancin hydrochloride
- CAS No.
- 2227366-51-8
- Chemical Name
- Dalbavancin hydrochloride
- Synonyms
- BI-397 hydrochloride;MDL-63397 hydrochloride;Dalbavancin Hydrochloride(Mixture)
- CBNumber
- CB28029346
- Molecular Formula
- C88H101Cl3N10O28
- Formula Weight
- 1853.17
- MOL File
- 2227366-51-8.mol
Dalbavancin hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO: ≥ 24 mg/mL (12.95 mM)
- form
- Solid
- color
- White to light yellow
- Water Solubility
- Water: 50 mg/mL (26.98 mM)
N-Bromosuccinimide Price
- Product number
- CS-3579
- Product name
- Dalbavancinhydrochloride
- Purity
- 99.48%
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-3579
- Product name
- Dalbavancinhydrochloride
- Purity
- 99.48%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-3579
- Product name
- Dalbavancinhydrochloride
- Purity
- 99.48%
- Packaging
- 10mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- CS-3579
- Product name
- Dalbavancinhydrochloride
- Purity
- 99.48%
- Packaging
- 25mg
- Price
- $528
- Updated
- 2021/12/16
- Product number
- CS-3579
- Product name
- Dalbavancinhydrochloride
- Purity
- 99.48%
- Packaging
- 50mg
- Price
- $720
- Updated
- 2021/12/16
Dalbavancin hydrochloride Chemical Properties,Usage,Production
Biological Activity
Dalbavancin hydrochloride(MDL-63397 hydrochloride) is a semi-synthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90 of 0.06 μg/mL and 0.25 μg/mL, respectively.
in vitro
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA ), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
in vivo
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
| Animal Model: | Female BALB/c mice (6-8 weeks) challenged with Ames strain of B . anthracis |
| Dosage: | 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg |
| Administration: | Intraperitoneal injection ; every 36 h or 72 h; for 14 days |
| Result: | The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h. |
Dalbavancin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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