4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE

Product Name: 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
CAS No.: 67139-79-1
Chemical Name: 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
Synonyms: Nsc293337;6-dichloro-1H-pyrrolo[3;4,6-Dichloro-5-azaindole ;4,6-Dichloropyrrolo[3,2-c]pyridine;4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE;1H-Pyrrolo[3,2-c]pyridine, 4,6-dichloro-
CBNumber: CB2837882
Molecular Formula: C7H4Cl2N2
Formula Weight: 187.03
MOL File: 67139-79-1.mol

More

Less

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Property

Melting point:: 258 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 371.6±37.0 °C(Predicted)
Density: 1.571±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.40±0.40(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C7H4Cl2N2/c8-6-3-5-4(1-2-10-5)7(9)11-6/h1-3,10H
InChIKey: ZTBYPLYMOIIANS-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=CC2NC=CC1=2

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: D482085
Product name: 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging: 50mg
Price: $110
Updated: 2021/12/16

TRC

Product number: D482085
Product name: 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging: 100mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD148713
Product name: 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging: 50mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD148713
Product name: 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging: 100mg
Price: $121
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD148713
Product name: 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging: 250mg
Price: $240
Updated: 2021/12/16

More

Less

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Chemical Properties,Usage,Production

Uses

4,6-dichloro-1H-pyrrolo[3,2-c]pyridine is an organic intermediate that can be used to prepare anti-influenza virus replication inhibitors.

Synthesis

1826-67-1

25194-01-8

67139-79-1

Step A: Synthesis of 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine: 2,6-dichloro-4-nitropyridine (11 g, 57 mmol) was dissolved in anhydrous tetrahydrofuran (300 mL) and cooled to -78 °C. Magnesium vinyl bromide (1M THF solution, 200 mL, 200 mmol) was added dropwise with stirring. The reaction was kept at -78 °C for 1 h, followed by a slow warming to -20 °C. Upon completion of the reaction, the reaction was quenched with 200 mL of saturated aqueous ammonium chloride solution. The reaction mixture was transferred to a partition funnel and the aqueous layer was extracted with ethyl acetate (200 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by Combi fast chromatography, first using a 120 g silica gel column eluting with a gradient of cyclohexane/ethyl acetate (0-100%), followed by switching to a 40 g silica gel column eluting with a gradient of dichloromethane/ethyl acetate (0-10%) to afford 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine as a brown solid (0.150 g, 1.4% yield) .

References

[1] Patent: WO2013/156431, 2013, A1. Location in patent: Page/Page column 52

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Suppliers

China 98 Germany 1 India 1 United Kingdom 2 United States 13 Global 115

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

D-L Chiral Chemicals, LLC

Tel: --
Fax: --
Country: United States
ProdList: 977
Advantage: 42

RnD SciChem, LLC

Tel: --
Fax: --
Email: rndscichem@gmail.com
Country: United States
ProdList: 569
Advantage: 0

Pure Chemistry Scientific Inc

Tel: --
Fax: --
Email: sales@purechems.com
Country: United States
ProdList: 2321
Advantage: 50

Chontech, Inc.

Tel: --
Fax: --
Email: chontech@yahoo.com
Country: United States
ProdList: 1101
Advantage: 30

More

Less

View Lastest Price from 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE manufacturers

Career Henan Chemical Co

Product: 4,6-Dichloro-5-azaindole 67139-79-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

Career Henan Chemical Co

Product: 4,6-Dichloro-5-azaindole 67139-79-1
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-09

67139-79-1, 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINERelated Search:

1H-Pyrrolo[3,2-c]pyridine, 7-broMo-4-chloro- 7-CHLORO-4-METHYL-1H-PYRROLO[2,3-C]PYRIDINE 7-CHLORO-5-METHYL-1H-PYRROLO[2,3-C]PYRIDINE 1H-Pyrrolo[2,3-c]pyridine, 4,7-dibroMo- 6-Hydroxy-5-azaindole 4-BROMO-7-METHOXY-6-AZAINDOLE 4-HYDROXY-5-AZAINDOLE 4-METHOXY-5-AZAINDOLE 7-Aza-2-oxindole-6-carboxylic acid Methyl este 3-BROMO-4-METHOXY-5-AZAINDOLE 4-bromo-7-chloro-1H-pyrrolo[2,3-c]pyridine 3-Iodo-7-Methoxy-4-azaindole 4-Methoxy-3-nitro-5-azaindole 1H-Pyrrolo[3,2-c]pyridine, 4-broMo-7-chloro- 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE 4-CHLORO-5-AZAINDOLE Methyl 4,6-dichloro-5-azaindole-2-carboxylate 6-CHLORO-5-AZAINDOLE

Nsc293337

6-dichloro-1H-pyrrolo[3

1H-Pyrrolo[3,2-c]pyridine, 4,6-dichloro-

4,6-Dichloro-5-azaindole

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE

4,6-Dichloropyrrolo[3,2-c]pyridine

67139-79-1

CHIRAL CHEMICALS

Heterocycle-Pyridine series