ChemicalBook > CAS DataBase List > 2-Fluoro-5-bromoanisole

2-Fluoro-5-bromoanisole

Product Name
2-Fluoro-5-bromoanisole
CAS No.
103291-07-2
Chemical Name
2-Fluoro-5-bromoanisole
Synonyms
2-fluoro-bromoanisole;2-fluoro-5-bromoanisole;2-FLUORO-5-BROMO ANISOLE,=98%;4-Bromo-1-fluoro-2-methoxybenzene;Benzene,4-broMo-1-fluoro-2-Methoxy;4-Bromo-1-fluoro-2-methoxybenzene, 5-Bromo-2-fluorophenyl methyl ether
CBNumber
CB2854827
Molecular Formula
C7H6BrFO
Formula Weight
205.02
MOL File
103291-07-2.mol
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2-Fluoro-5-bromoanisole Property

Boiling point:
205.8±20.0 °C(Predicted)
Density 
1.531±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
Appearance
Colorless to off-white Liquid
InChIKey
SEVMQEIGENUPIE-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36-52
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B685780
Product name
5-Bromo-2-fluoroanisole
Packaging
1g
Price
$115
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64624
Product name
5-Bromo-2-fluoroanisole
Packaging
250g
Price
$625
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64624
Product name
5-Bromo-2-fluoroanisole
Packaging
50g
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64624
Product name
5-Bromo-2-fluoroanisole
Packaging
100g
Price
$280
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011648
Product name
2-FLUORO-5-BROMO ANISOLE
Purity
95.00%
Packaging
5G
Price
$770.39
Updated
2021/12/16
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2-Fluoro-5-bromoanisole Chemical Properties,Usage,Production

Chemical Properties

Pale yellow liquid

Uses

5-Bromo-2-fluoroanisole is a reactant used in the preparation of bicyclic substituted hydroxyphenylmethanone derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis.

Synthesis

112204-58-7

74-88-4

103291-07-2

5-Bromo-2-fluorophenol (13.0 g, 68.1 mmol) and iodomethane (19.3 g, 136 mmol) were dissolved in DMF (120 mL) and potassium carbonate (18.8 g, 136 mmol) was added. The reaction mixture was stirred at room temperature for 65 hours. After completion of the reaction, water (150 mL) was added to the reaction solution and extracted with ethyl acetate (100 mL x 1,50 mL x 2). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give a light yellow oily crude product (29.0 g). The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10:1) to afford 5-bromo-2-fluoroanisole (14.2 g, yield: quantitative) in colorless oily form. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) and 19F-NMR (376 MHz, CDCl3): 1H-NMR δ 3.88 (s, 3H), 6.95 (dd, J = 8.6 and 10.8 Hz, 1H), 7.02 (ddd, J = 2.2,4.2 and 8.6 Hz, 1H), 7.08 (dd. J = 2.2 and 7.6 Hz, 1H); 19F-NMR δ -137 (s, 1F).

References

[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0452; 0453
[2] Patent: WO2006/76246, 2006, A2. Location in patent: Page/Page column 87
[3] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[4] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71

2-Fluoro-5-bromoanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Fluoro-5-bromoanisole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Fluoro-5-bromoanisole 103291-07-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-21
Career Henan Chemical Co
Product
2-Fluoro-5-bromoanisole 103291-07-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

103291-07-2, 2-Fluoro-5-bromoanisoleRelated Search:

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  • 2-fluoro-5-bromoanisole
  • 2-FLUORO-5-BROMO ANISOLE,=98%
  • 4-Bromo-1-fluoro-2-methoxybenzene
  • 4-Bromo-1-fluoro-2-methoxybenzene, 5-Bromo-2-fluorophenyl methyl ether
  • Benzene,4-broMo-1-fluoro-2-Methoxy
  • 2-fluoro-bromoanisole
  • 103291-07-2
  • Fluorine series