Alagebrium chloride

Product Name: Alagebrium chloride
CAS No.: 341028-37-3
Chemical Name: Alagebrium chloride
Synonyms: ALT-711;2-(4,5-dimethylthiazol-3-ium-3-yl)-1-phenyl-ethanone chloride;Mancef;250g - 1kg;ALT-711,AlagebriuM;alagebrium chloride;(Alagebrium) (thiazolium salt);Alagebrium chloride, 10 mM in DMSO;Dimethyl-3-(2-oxo-2-phenyl)-chloride;4,5 diMethyl 3-2 (2 oxo-2 phenyl) chloride
CBNumber: CB2855521
Molecular Formula: C13H14ClNOS
Formula Weight: 267.77
MOL File: 341028-37-3.mol

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Alagebrium chloride Property

Melting point:: 212 °C(dec.)
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Merck: 14,203
InChI: InChI=1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1
InChIKey: MKOMESMZHZNBIZ-UHFFFAOYSA-M
SMILES: C([N+]1=CSC(C)=C1C)C(C1C=CC=CC=1)=O.[Cl-]
CAS DataBase Reference: 341028-37-3(CAS DataBase Reference)

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3166
Product name: Alagebrium Chloride
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: A3166
Product name: Alagebrium Chloride
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $152
Updated: 2023/06/20

TRC

Product number: A470405
Product name: Alagebrium Chloride
Packaging: 5g
Price: $435
Updated: 2021/12/16

Chem-Impex

Product number: 37625
Product name: Alagebriumchloride,≥98%(HPLC)
Purity: ≥98%(HPLC)
Packaging: 200MG
Price: $50.09
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD140267
Product name: 4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazol-3-ium chloride
Packaging: 5G
Price: $277
Updated: 2021/12/16

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Alagebrium chloride Chemical Properties,Usage,Production

Uses

Prevention and treatment of cardiovascular complications of aging, diabetes, and end stage renal disease; diabetic multisymptom pathology (other than cardiovascular) including retinopathy, neuphropathy, neuropathy, and ulcers (advanced glycosylation endpr.

Uses

Alagebrium Chloride is used in the treatment of obesity resulting from a diet high in both fat and AGE that causes renal impairment in animals. Alagebrium inhibits AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression.

in vivo

Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice^[1]. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium^[2].

Alagebrium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Alagebrium chloride Suppliers

Americas 1 China 108 Europe 1 Germany 1 India 2 Japan 1 United Kingdom 1 United States 8 Global 123

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4511
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CHG Opto-Electronic Corporation Limited

Tel: 2537653158 16621191650
Fax: QQ 2537653158
Email: 2537653158@qq.com
Country: China
ProdList: 7211
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
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Suzhou Ryan Pharmaceutical Technology Co., Ltd.

Tel: 0512-68780025 18962125825
Email: sales@ryanchem.com
Country: China
ProdList: 169
Advantage: 62

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1996
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
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UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

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View Lastest Price from Alagebrium chloride manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: Alagebrium chloride 341028-37-3
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-19

Career Henan Chemical Co

Product: Alagebrium chloride 341028-37-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-08

341028-37-3, Alagebrium chlorideRelated Search:

Dacthal Ammonium chloride Choline chloride L-PICEIN Benzothiazole Xylene Chlorodimethylphenylsilane Sodium chloride Thionyl chloride Zinc chloride Dimethyl ether 2-Mercaptobenzothiazole Fosthiazate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Dimethyl fumarate Potassium chloride Dimethyl sulfoxide N,N-Dimethylformamide

2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride

ALT-711

Dimethyl-3-(2-oxo-2-phenyl)-chloride

(Alagebrium) (thiazolium salt)

4,5-Dimethyl-3-(2-oxo-2-phenyl)-thiazoliumchloride

2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone chloride

2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenyl-ethanone chloride

2-(4,5-dimethylthiazol-3-ium-3-yl)-1-phenyl-ethanone chloride

250g - 1kg

4,5 diMethyl 3-2 (2 oxo-2 phenyl) chloride

ThiazoliuM,4,5-diMethyl-3-(2-oxo-2-phenylethyl)-, chloride (9CI)

4,5-Dimethyl-3-(2-oxo-2-phenylethyl)-thiazol-3-ium chloride

4,5-dimethyl-3-(2-oxo-2-phenylethyl)thiazolium chloride

alagebrium chloride

4,5-diMethyl-3-(2-oxo-2-phenylethyl)-thiazol...

ALT-711,AlagebriuM

2-(4,5-dimethyl-3-thiazol-3-iumyl)-1-phenylethanone chloride

Thiazolium, 4,5-dimethyl-3-(2-oxo-2-phenylethyl)-, chloride

Mancef

Alagebrium chloride, 10 mM in DMSO

341028-37-3

C13H14NOSCl