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Ornipressin

Product Name
Ornipressin
CAS No.
3397-23-7
Chemical Name
Ornipressin
Synonyms
POR-8;Ornipressin;POR-8 Sandoz;Orn8-vasopressin;Ornipressin Acetate;914453-98-8 (acetate);Ornithine-vasopressin;Ornipressin USP/EP/BP;8-Ornithinevasopressin;Ornipressin,POR-8, >99%
CBNumber
CB2874702
Molecular Formula
C45H63N13O12S2
Formula Weight
1042.19
MOL File
3397-23-7.mol
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Ornipressin Property

Boiling point:
1616.2±65.0 °C(Predicted)
Density 
1.320±0.06 g/cm3(Predicted)
solubility 
DMSO (Very Slightly, Sonicated), Methanol (Very Slightly, Sonicated)
pka
9.90±0.15(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
MUNMIGOEDGHVLE-UHFFFAOYSA-N
SMILES
N1(CCCC1C(=O)NC(CCCN)C(=O)NCC(=O)N)C(=O)C1CSSCC(N)C(=O)NC(C(NC(CC2C=CC=CC=2)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)N1)=O)CC1=CC=C(O)C=C1
CAS DataBase Reference
3397-23-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb611470
Product name
Ornipressin
Packaging
5mg
Price
$229.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611470
Product name
Ornipressin
Packaging
10mg
Price
$306
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611470
Product name
Ornipressin
Packaging
50mg
Price
$402.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb372621
Product name
Ornipressin Acetate
Purity
> 95%
Packaging
1mg
Price
$581.4
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
52610
Product name
Ornipressin
Packaging
10mg
Price
$675
Updated
2021/12/16
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Ornipressin Chemical Properties,Usage,Production

Originator

POR-8 ,Sandoz,W. Germany ,1977

Uses

Ornipressin is an analogue of Vasopressin. Ornipressin is used as a vasoconstrictor, haemostatic and renal agent.

Definition

ChEBI: Ornipressin is an oligopeptide.

Manufacturing Process

(a)N-α-carbobenzoxy-N-δ-p-toluenesulfonyl-L-ornithyl-glycine ethyl ester: 104 g of N-α-carbobenzoxy-N-δ-p-toluenesulfonyl-L-ornithine and 27 g of glycine ethyl ester are dissolved in 450 cc of acetonitrile, the mixture is cooled at 0°C, 51 g of dicyclohexyl carbodiimide are added and the mixture is shaken at room temperature for 4 hours. Precipitated dicyclohexyl urea is filtered off and washed with acetonitrile. The whole filtrate is evaporated in a vacuum. The residue crystallizes after the addition of petroleum ether. After recrystallization from n-propanol, 93 g of N-α-carbobenzoxy-N-δ-toluenesulfonyl-L-ornithylglycine ethyl ester are obtained; melting point 136°C; [α]D22 = -6.5° (96% ethanol).
(b) N-carbobenzoxy-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithyl-glycinamide: 90 g of N-α-carbobenzoxy-N-δ-p-toluenesulfonyl-L-ornithyl-glycine ethyl ester are dissolved in 800 cc of anhydrous acetic acid which has been saturated with hydrogen bromide. The mixture is left to stand for one hour at 20°C, evaporated in a vacuum at a temperature below 40°C and the residue washed carefully with diethyl ether. The residue is dissolved in 500 cc of acetonitrile, 25 cc of triethylamine and 43 g of N-carbobenzoxy-L-proline are added, cooling is effected at 0°C, 355 g of dicyclohexyl carbodiimide are then added and the mixture shaken overnight at 20°C. After filtering off dicyclohexyl urea, the filtrate is evaporated in a vacuum at 30°C, the residue dissolved in ethyl acetate and this solution is washed with dilute sulfuric acid and aqueous ammonia. After drying over sodium sulfate, the ethyl acetate is removed by evaporation in a vacuum and the residue dissolved in 1 liter of absolute ethanol. The solution is cooled at 0°C, saturated with ammonia and left to stand overnight at 20°C. After evaporating in a vacuum at 30°C, the residue is recrystallized from dimethylformamide/ethyl acetate. 58 g of Ncarbobenzoxy-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithyl-glycinamide are obtained: melting point 122°C (with decomposition).
(c) N-carbobenzoxy-L-glutaminyl-L-asparaginyl-S-benzyl-L-cystsinyl-L-prolyl-Nδ-p-toluenesulfonyl-L-ornithyl-glycinamide: 100 g of N-carbobenzoxy-L-prolylN-δ-p-toluenesulfonyl-L-ornithyl-glycinamide are dissolved in 500 cc of anhydrous acetic acid which has been saturated with hydrogen bromide, the solution is left to stand for one hour at 20°C and is evaporated in a vacuum at a temperature below 40°C. The residue is carefully washed with diethyl ether and then added to a solution of 100 g of N-carbobenzoxy-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-azide and 26 cc of triethylamine in 1,000 cc of dimethylformamide. The mixture is left to stand overnight at 20°C, 3,000 cc of ethyl acetate are added thereto, the precipitate is filtered off and washing is effected with ethyl acetate. 105 g of N-carbo-benzoxy-Lglutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-Lornithyl-glycinamide are obtained; melting point 193°C; [α]D20 = 38.5°(dimethylformamide).
(d) N-carbobenzoxy-S-benzyl-L-cysteinyl-L-tyrosyl-L-phenyl-alanyl-Lglutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-Lornithyl-glycinamide: 50 g N-carbobenzoxy-L-glutaminyl-L-asparaginyl-Sbenzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithyl-glycinamide are dissolved in 250 cc of anhydrous acetic acid which has been saturated with hydrogen bromide and the solution is left to stand for one hour at 20°C. After evaporating the solvent in a vacuum at a temperature below 40°C, the residue is carefully washed with diethyl ether and a solution of 31.5 g of Ncarbobenzoxy-S-benzyl-L-cysteinyl-L-tyrosyl-L-phenylalanine-azide and 7.5 cc of triethylamine in 250 cc of dimethylformamide is added thereto. The mixture is left to stand for 2 days at 20°C. 1,000 cc of ethyl acetate are subsequently added and the precipitate is washed with ethyl acetate. After drying in a vacuum at 30°C. the product is washed with warm methanol. 45 g of Ncarbobenzoxy-S-benzyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-L-prolyl-N-δ-p-toluenesulfonyl-L-ornithylglycinamide are obtained; melting point 224°C.
(e) L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinylL-prolyl-L-ornirhyl-glycinamide: The necessary amount of sodium or potassium metal is added to a solution of 5 g of N-carbobenzoxy-S-benzyl-L-cysteinyl-Ltyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolylN-δ-p-toluenesulfonyl-L-ornithyl-glycinamide in 1,200 cc of dry liquid ammonia, while stirring at the boiling temperature of the solution, to give a stable blue coloration. After the addition of 3 g of ammonium chloride, the solution is evaporated to dryness. The residue contains L-cysteinyl-L-tyrosyl-Lphenyl-alanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithylglycinamide.

Therapeutic Function

Vasoconstrictor

Ornipressin Preparation Products And Raw materials

Raw materials

Preparation Products

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Ornipressin Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Alabiochem Tech.Co., Ltd.
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0512-58900862 400-0707518
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0086-512-56765862
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sales@alabiochem.com
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China
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021-54306202 13764082696
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info@hanhongsci.com
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China
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021-50135380
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shchemsky@sina.com
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China
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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China
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Cellmano Biotech Limited
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0551-65326643 18156095617
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+86 21 61551611
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MedChemexpress LLC
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021-58955995
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United States
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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View Lastest Price from Ornipressin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ornipressin 3397-23-7
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-12
Shandong Huizhihan Supply Chain Co., Ltd
Product
Ornipressin 3397-23-7
Price
US $0.00-0.00/box
Min. Order
1box
Purity
99%
Supply Ability
1000
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
Ornipressin 3397-23-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100tons
Release date
2023-09-08

3397-23-7, OrnipressinRelated Search:


  • Ornipressin Acetate
  • 1-[19-Amino-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[4-amino-1-(carbamoylmethylcarbamoyl)butyl]pyrrolidine-2-carboxamide
  • 8-Ornithinevasopressin
  • Ornipressin
  • VASOPRESSIN, 8-L-ORNITHINE-
  • 914453-98-8 (acetate)
  • POR-8;914453-98-8 (ACETATE)
  • N-[5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl
  • Ornipressin,POR-8, >99%
  • L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2
  • POR-8 Sandoz
  • 8-L-Ornithine-vasopressin
  • Orn8-vasopressin
  • Ornithine-vasopressin
  • vasopressin 8-ornithine
  • 8-ornipressin vasopressin
  • POR-8
  • Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Orn-Gly-NH2(Disulfide,Cys1 and Cys6)
  • Ornipressin USP/EP/BP
  • *Alfentanil Hydrochloride-d3
  • 3397-23-7
  • C45H63N13O12S2
  • Amino Acid Derivatives
  • Peptide