Chloramphenicol hemisuccinate
- Product Name
- Chloramphenicol hemisuccinate
- CAS No.
- 3544-94-3
- Chemical Name
- Chloramphenicol hemisuccinate
- Synonyms
- Chronicin foam;Paraxin succinate;Kemicetine succinate;Levomycetin succinate;Chloromycetin succinate;Chloramphenicol succinate;Levomycetin hemisuccinate;Chloramphenicol 3-succinate;Chloramphenicol hemisuccinate;Chloramphenicol monosuccinate
- CBNumber
- CB2925965
- Molecular Formula
- C15H16Cl2N2O8
- Formula Weight
- 423.2
- MOL File
- 3544-94-3.mol
Chloramphenicol hemisuccinate Property
- Melting point:
- 127 °C
- Boiling point:
- 716.3±60.0 °C(Predicted)
- Density
- 1.6769 (rough estimate)
- refractive index
- 1.7350 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- A solid
- pka
- 4.36±0.17(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25453
- Product name
- Chloramphenicol Succinate
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 25453
- Product name
- Chloramphenicol Succinate
- Purity
- ≥99%
- Packaging
- 25mg
- Price
- $433
- Updated
- 2024/03/01
- Product number
- C325123
- Product name
- ChloramphenicolSuccinate
- Packaging
- 10mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- C325123
- Product name
- ChloramphenicolSuccinate
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 0086BA
- Product name
- 4-[2-[(Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoicacid
- Packaging
- 25mg
- Price
- $580
- Updated
- 2021/12/16
Chloramphenicol hemisuccinate Chemical Properties,Usage,Production
Description
Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol. It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro. Chloramphenicol succinate reduces human leukocyte migration in vitro. In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively. Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury. Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.
Uses
Chloramphenicol succinate is prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug. Chloramphenicol succinate represents an alternative pro-drug strategy for chloramphenicol that has found a niche in surface antibiotic treatment in surgery. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.
Definition
ChEBI: Chloramphenicol succinate is a member of amphetamines and a hemisuccinate.
Chloramphenicol hemisuccinate Preparation Products And Raw materials
Raw materials
Preparation Products
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