Chloramphenicol hemisuccinate

Product Name: Chloramphenicol hemisuccinate
CAS No.: 3544-94-3
Chemical Name: Chloramphenicol hemisuccinate
Synonyms: Chronicin foam;Paraxin succinate;Kemicetine succinate;Levomycetin succinate;Chloromycetin succinate;Chloramphenicol succinate;Levomycetin hemisuccinate;Chloramphenicol 3-succinate;Chloramphenicol hemisuccinate;Chloramphenicol monosuccinate
CBNumber: CB2925965
Molecular Formula: C15H16Cl2N2O8
Formula Weight: 423.2
MOL File: 3544-94-3.mol

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Chloramphenicol hemisuccinate Property

Melting point:: 127 °C
Boiling point:: 716.3±60.0 °C(Predicted)
Density: 1.6769 (rough estimate)
refractive index: 1.7350 (estimate)
storage temp.: Store at -20°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form: A solid
pka: 4.36±0.17(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25453
Product name: Chloramphenicol Succinate
Purity: ≥99%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 25453
Product name: Chloramphenicol Succinate
Purity: ≥99%
Packaging: 25mg
Price: $433
Updated: 2024/03/01

TRC

Product number: C325123
Product name: ChloramphenicolSuccinate
Packaging: 10mg
Price: $105
Updated: 2021/12/16

TRC

Product number: C325123
Product name: ChloramphenicolSuccinate
Packaging: 5mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 0086BA
Product name: 4-[2-[(Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoicacid
Packaging: 25mg
Price: $580
Updated: 2021/12/16

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Chloramphenicol hemisuccinate Chemical Properties,Usage,Production

Description

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol. It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro. Chloramphenicol succinate reduces human leukocyte migration in vitro. In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively. Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury. Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.

Uses

Chloramphenicol succinate is prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug. Chloramphenicol succinate represents an alternative pro-drug strategy for chloramphenicol that has found a niche in surface antibiotic treatment in surgery. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.

Definition

ChEBI: Chloramphenicol succinate is a member of amphetamines and a hemisuccinate.

Chloramphenicol hemisuccinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Chloramphenicol hemisuccinate Suppliers

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Chloramphenicol 3-monosuccinate

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Chloramphenicol hemisuccinate

Chloramphenicol hydrogen succinate

Chloramphenicol monosuccinate

Chloromycetin succinate

Chronicin foam

Kemicetine succinate

Levomycetin hemisuccinate

Levomycetin succinate

Paraxin succinate

Succinic acid, ester with chloramphenicol (6CI)

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4-[2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid

4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoicaci

3544-94-3

C15H16Cl2N2O8