Lapatinib ditosylate
- Product Name
- Lapatinib ditosylate
- CAS No.
- 388082-78-8
- Chemical Name
- Lapatinib ditosylate
- Synonyms
- Lapatinib ditosylate Monohydrate;Lapatinib tosilate;Lapatinib ditosylate hydrate;Lapatinb;GW2016 ditosylate;GW-572016;GW572016;(E)-Ferulic acid-d;lapatinib(GW572016);Lapatinib Ditosilate;Lapatinib ditosylate
- CBNumber
- CB2966227
- Molecular Formula
- C41H40ClFN4O11S3
- Formula Weight
- 925.46
- MOL File
- 388082-78-8.mol
Lapatinib ditosylate Property
- Melting point:
- >200oC (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Yellow
- CAS DataBase Reference
- 388082-78-8(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- L175813
- Product name
- LapatinibDitosylateMonohydrate
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 281198
- Product name
- Lapatinib ditosylate
- Packaging
- 50mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 015474
- Product name
- Lapatinib Ditosylate
- Packaging
- 5mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- 090594
- Product name
- Lapatinib ditosylate hydrate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $567
- Updated
- 2021/12/16
- Product number
- orb180754
- Product name
- Lapatinib ditosylate
- Purity
- >98%
- Packaging
- 250mg
- Price
- $615.4
- Updated
- 2021/12/16
Lapatinib ditosylate Chemical Properties,Usage,Production
Uses
anticancer
Uses
binds to a(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors atypical antipsychotic agent
Uses
Lapatinib ditosylate monohydrate is a form of Lapatinib I, an orally active drug for breast cancer as a dual EGFR and erbB-?2 inhibitor.
Definition
ChEBI: Lapatinib ditosylate monohydrate is a member of quinazolines.
General Description
Lapatinib is available in 250-mg tablets for oral administrationand is used in combination with cabecitabine in thetreatment of breast cancer for those patients that over expressthe type 2 EGF-R and who have previously receivedtaxane, anthracycline, and trastuzumab therapy. The type 2EGF-R is one subtype of this receptor and is also known asHER2 or ErbB-2. The agent is a receptor TK inhibitor targetingthe ErbB-1 and ErbB-2 subtypes. Binding occurs atthe ATP-binding site and thereby prevents phosphorylationand the subsequent activation of other kinase enzymes.ErbB-1 overexpression occurs in approximately27% to 30% of breast cancers, while ErbB-2 is over expressedin 20% to 25% of cases.The agent has demonstratedIC50 values of ＜0.2μM against ErbB-1 and 2 fromseveral different cancer cell lines and dissociates slowly(t1/2＝300 min) from these receptor TKs.The drug isboth a substrate and an inhibitor of the efflux transportersPgp and BCRP. It is also an inhibitor of the hepatic uptaketransporter OATP1B1, which is an organic anion transporter.The absorption of lapatinib is incomplete andvariable after oral administration. The agent is extensivelymetabolized by CYP3A4 and CYP3A5, with minor contributionsfrom CYP2C19 and CYP2C8. Lapatinib inhibitsCYP3A and CYP2C8 at clinically relevant concentrations.The agent is highly (99%) protein bound and eliminatedprimarily in the feces. The half-life of the agent increaseupon repeated dosing, taking 6 days to reach steady statethat gives an effective half-life of 24 hours. The most commonlyseen adverse effects of lapatinib therapy are skinrash and diarrhea. Skin rash is commonly seen with manyof the other TK inhibitors and agents that target ErbB-1.Lapatinib-induced diarrhea is usually mild to moderate.There have been reports of decreases in left ventricularejection fraction associated with the agent, although thisappears to occur only rarely and is reversible upon discontinuationof therapy.
target
EGFR
Lapatinib ditosylate Preparation Products And Raw materials
Raw materials
Preparation Products
Lapatinib ditosylate Suppliers
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View Lastest Price from Lapatinib ditosylate manufacturers
- Product
- Lapatinib ditosylate 388082-78-8
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-03-18
- Product
- Lapatinib ditosylate 388082-78-8
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 15tons
- Release date
- 2023-11-28
- Product
- Lapatinib Ditosylate 388082-78-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%，single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2023-12-29