ChemicalBook > CAS DataBase List > Davercin

Davercin

Product Name
Davercin
CAS No.
55224-05-0
Chemical Name
Davercin
Synonyms
erythromycin A cyclic 11,12-carbonate;CWE;DAVERCIN;Dravercin;Davercin USP/EP/BP;Erythromycin cycloester;Eritromicina A carbonato;Erythromycin Impurity 10;Erythromycin Impurity 50;Erythromycin Cyclocarbonate
CBNumber
CB2966540
Molecular Formula
C38H65NO14
Formula Weight
759.93
MOL File
55224-05-0.mol
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Davercin Property

Melting point:
>135°C (dec.)
Boiling point:
859.8±65.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
13.49±0.70(Predicted)
form 
Solid
color 
White
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Safety

Toxicity
LD50 oral in rat: 5800mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
1mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
5mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
10mg
Price
$332
Updated
2024/03/01
Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
25mg
Price
$746
Updated
2024/03/01
TRC
Product number
E650045
Product name
ErythromycinCyclocarbonate
Packaging
2.5mg
Price
$110
Updated
2021/12/16
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Davercin Chemical Properties,Usage,Production

Description

Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.

Uses

Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.

Uses

Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.

Definition

ChEBI: Davercin is an aminoglycoside.

Davercin Preparation Products And Raw materials

Raw materials

Preparation Products

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Davercin Suppliers

China 99 China Hong Kong 1 India 4 United Kingdom 1 United States 16 Global 121
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
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Waterstone Technology, LLC
Tel
--
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Email
sales@waterstonetech.com
Country
United States
ProdList
6786
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HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
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65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
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View Lastest Price from Davercin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Davercin 55224-05-0
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07
Career Henan Chemical Co
Product
Davercin 55224-05-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 784
Release date
2019-09-02

55224-05-0, DavercinRelated Search:

Erythromycin 3-Dimethylaminopropylamine CYCLANDELATE CHLOROPHOSPHONAZO III Dimethyl carbonate Ethylene carbonate Lithium carbonate Calcium carbonate Sodium carbonate Roxithromycin CYCLOPENTOLATE Erythromycin Impurity 9 DIBUTYL CARBONATE 4-ETHYL-1,3-DIOXOLAN-2-ONE (S)-(-)-Propylene Carbonate (R)-(+)-Propylene carbonate 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE (R)-(+)-4-(METHOXYMETHYL)-1,3-DIOXOLAN-2-ONE

  • Erythromycin Cyclocarbonate
  • DAVERCIN
  • CWE
  • erythromycin A cyclic 11,12-carbonate
  • (1R,2R,5R,6S,7S,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione
  • Carbonato ciclico de eritromicina a
  • Carbonato ciclico de eritromicina A [spanish]
  • Cykliczny weglan erytromycyny a
  • Cykliczny weglan erytromycyny A [polish]
  • Dravercin
  • Eritromicina A carbonato
  • Eritromicina A carbonato [spanish]
  • ErythroMycin A 11,12-carbonate, ErythroMycin A cyclic 11,12-carbonate, ErythroMycin cyclic carbonate
  • Cyclic ester of erythroMycin
  • cyclic 11,12-carbonate erythromycin
  • Erythromycin Impurity 10
  • Erythromycin Cyclocarbonate, >98%
  • Erythromycin, cyclic 11,12-carbonate
  • Erythromycin Impurity 20（Erythromycin Cyclocarbonate）
  • Davercin USP/EP/BP
  • Erythromycin Cyclic11,12-Carbonate(Davercin)
  • Erythromycin Impurity 50
  • (3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-hydroxy-8-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3a,7,9,11,13,15-hexamethyloctahy
  • Davercin (Erythromycin cyclocarbonate)
  • Erythromycin cycloester
  • Erythromycin cyclic carbonate
  • Erythromycin Impurity 10(Davercin)
  • 55224-05-0
  • C38H65NO14
  • Inhibitors
  • 55224-05-0