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BISINDOLYLMALEIMIDE I HYDROCHLORIDE

Product Name
BISINDOLYLMALEIMIDE I HYDROCHLORIDE
CAS No.
176504-36-2
Chemical Name
BISINDOLYLMALEIMIDE I HYDROCHLORIDE
Synonyms
BIS-I HCl;GO-6860 HCl;BIM 1 hydrochloride;GF 109203X hydrochloride >=95%;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
CBNumber
CB2972282
Molecular Formula
C25H25ClN4O2
Formula Weight
448.95
MOL File
176504-36-2.mol
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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form 
Orange-red solid
color 
Orange to red
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Safety

WGK Germany 
3
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B6292
Product name
GF 109203X hydrochloride
Purity
≥95%
Packaging
250μg
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
203291
Product name
Bisindolylmaleimide I, Hydrochloride
Purity
An enhanced water-soluble form of Bisindolylmaleimide I.
Packaging
1mg
Price
$187
Updated
2024/03/01
Sigma-Aldrich
Product number
203291
Product name
Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
Purity
An enhanced water-soluble form of Bisindolylmaleimide I.
Packaging
250μg
Price
$68.9
Updated
2023/06/20
Sigma-Aldrich
Product number
203291
Product name
Bisindolylmaleimide I, Hydrochloride
Purity
An enhanced water-soluble form of Bisindolylmaleimide I.
Packaging
250ug
Price
$65.2
Updated
2021/12/16
Cayman Chemical
Product number
21180
Product name
Bisindolylmaleimide I (hydrochloride)
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

Uses

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

General Description

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

Biochem/physiol Actions

Inhibitor of protein kinase C; potent inhibitor of GSK-3.

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Suppliers

China 18 Switzerland 1 United Kingdom 1 United States 6 Global 26
Sigma-Aldrich
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TargetMol Chemicals Inc.
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Nanjing Tengyi Biotechnology Co., Ltd
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ATK CHEMICAL COMPANY LIMITED
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Guangzhou WeiBo Chemical Co., Ltd.
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176504-36-2, BISINDOLYLMALEIMIDE I HYDROCHLORIDERelated Search:

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  • BIM 1 hydrochloride
  • 3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
  • BisindolylMaleiMide I( Hydrochloride Salt)
  • BisindolylMaleiMide I . hydrochloride [GF-109203K
  • 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
  • 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
  • Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
  • GF 109203X hydrochloride >=95%
  • BIS-I HCl
  • GO-6860 HCl
  • 176504-36-2