BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- Product Name
- BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- CAS No.
- 176504-36-2
- Chemical Name
- BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- Synonyms
- BIS-I HCl;GO-6860 HCl;BIM 1 hydrochloride;GF 109203X hydrochloride >=95%;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
- CBNumber
- CB2972282
- Molecular Formula
- C25H25ClN4O2
- Formula Weight
- 448.95
- MOL File
- 176504-36-2.mol
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Property
- storage temp.
- 2-8°C
- solubility
- DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
- form
- Orange-red solid
- color
- Orange to red
Safety
- WGK Germany
- 3
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- B6292
- Product name
- GF 109203X hydrochloride
- Purity
- ≥95%
- Packaging
- 250μg
- Price
- $80.7
- Updated
- 2024/03/01
- Product number
- 203291
- Product name
- Bisindolylmaleimide I, Hydrochloride
- Purity
- An enhanced water-soluble form of Bisindolylmaleimide I.
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 203291
- Product name
- Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
- Purity
- An enhanced water-soluble form of Bisindolylmaleimide I.
- Packaging
- 250μg
- Price
- $68.9
- Updated
- 2023/06/20
- Product number
- 203291
- Product name
- Bisindolylmaleimide I, Hydrochloride
- Purity
- An enhanced water-soluble form of Bisindolylmaleimide I.
- Packaging
- 250ug
- Price
- $65.2
- Updated
- 2021/12/16
- Product number
- 21180
- Product name
- Bisindolylmaleimide I (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.
Uses
GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.
General Description
GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.
Biochem/physiol Actions
Inhibitor of protein kinase C; potent inhibitor of GSK-3.
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Suppliers
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- Country
- Switzerland
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