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PEROSPIRONE

Product Name
PEROSPIRONE
CAS No.
150915-41-6
Chemical Name
PEROSPIRONE
Synonyms
Perospirine;PEROSPIRONE;PEROSPIRONE HCL;[14C]-Perospirone;PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone;cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide;(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide;1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-;(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione;(3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
CBNumber
CB3101658
Molecular Formula
C23H30N4O2S
Formula Weight
426.57
MOL File
150915-41-6.mol
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PEROSPIRONE Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P288903
Product name
Perospirone
Packaging
10mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
M813
Product name
Perospirone
Packaging
25mg
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-0019906
Product name
Perospirone
Purity
99.51%
Packaging
10mg
Price
$120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008732
Product name
PEROSPIRONE
Purity
95.00%
Packaging
25MG
Price
$225.75
Updated
2021/12/16
ChemScene
Product number
CS-0019906
Product name
Perospirone
Purity
99.51%
Packaging
50mg
Price
$420
Updated
2021/12/16
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PEROSPIRONE Chemical Properties,Usage,Production

Description

Perospirone hydrochloride was launched in Japan as a new treatment of schizophrenia and other psychoses. This structurally-related analog of ziprasidone can be classically prepared by alkylation of 1-(3-benzisothiazolyl)-piperazine with the appropriate N- (chlorobutyl)-succinimide. As a result of an in vitro determination of its binding profile, perospirone demonstrated a high affinity for 5-HT2, 5-HT1A and D2 receptors as well as a significant but lower affinity for DI and al receptors. Interestingly, these differential effects on neurotransmitters with a high in vivo occupancy of 5-HT2A receptors with lower D2 occupancy seems to provide this new agent with a significantly lower propensity for the development of extrapyramidal symptoms (EPS) and tardive schizophrenia, the main sideeffects associated with classical antipsychotic therapy. Furthermore, perospirone exhibited anxiolytic-like effects in animal models. A long-term clinical trial (> 6 months) in a group of patients suffering from schizophrenia demonstrated the efficacy of perospirone over placebo for the treatment of the positive, negative and general symptoms of schizophrenia at doses of 12 mg to 96 mg t.i.d.

Originator

Sumitomo Pharm. (Japan)

Definition

ChEBI: (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione is a N-arylpiperazine.

brand name

Lullan

PEROSPIRONE Preparation Products And Raw materials

Raw materials

Preparation Products

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PEROSPIRONE Suppliers

China 44 Europe 2 Germany 1 India 1 United Kingdom 2 United States 9 Global 59
Henan Vcommend Consultrading Co., Ltd.
Tel
13393721940; 13393721940
Email
sales@vcommend.com
Country
China
ProdList
10005
Advantage
58
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7195
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Wuxi MinHua Biochem Pharmatech Co.,Ltd.
Tel
0510-0510-66903969 13961776301
Fax
0510-66903969
Email
mrweizhihua@sina.com
Country
China
ProdList
41
Advantage
58
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58

150915-41-6, PEROSPIRONERelated Search:

1,2-Cyclohexanedicarboximide 1,2-Cyclohexanedicarboximide etisazole PEROSPIRONE 3-Piperazinobenzisothiazole hydrochloride PEROSPIRONE HYDROCHLORIDE DIHYDRATE,PEROSPIRONE HYDROCHLORIDE HYDRATE,PEROSPIRONE HYDROCHLORIDE,Perospirone Hydrochloride Trihydrate cis-Octahydroisoindole 1,2-Benzisothiazol-3-amine

  • PEROSPIRONE
  • PEROSPIRONE HCL
  • 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- (9CI)
  • 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-
  • cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide
  • Perospirine
  • (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
  • (1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide
  • (3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione
  • (3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
  • [14C]-Perospirone
  • 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel-
  • PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone
  • deficits,atypical,Perospirone,SM-9018,Dopamine Receptor,5-hydroxytryptamine Receptor,5-HT Receptor,Orally,SM9018,schizophrenic,disease,Serotonin Receptor,cognitive,Inhibitor,SM 9018,inhibit,antipsychotic
  • 150915-41-6
  • C23H30N4O2S