PEROSPIRONE
- Product Name
- PEROSPIRONE
- CAS No.
- 150915-41-6
- Chemical Name
- PEROSPIRONE
- Synonyms
- Perospirine;PEROSPIRONE;PEROSPIRONE HCL;[14C]-Perospirone;PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone;cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide;(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide;1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-;(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione;(3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
- CBNumber
- CB3101658
- Molecular Formula
- C23H30N4O2S
- Formula Weight
- 426.57
- MOL File
- 150915-41-6.mol
PEROSPIRONE Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- P288903
- Product name
- Perospirone
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M813
- Product name
- Perospirone
- Packaging
- 25mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- CS-0019906
- Product name
- Perospirone
- Purity
- 99.51%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- API0008732
- Product name
- PEROSPIRONE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $225.75
- Updated
- 2021/12/16
- Product number
- CS-0019906
- Product name
- Perospirone
- Purity
- 99.51%
- Packaging
- 50mg
- Price
- $420
- Updated
- 2021/12/16
PEROSPIRONE Chemical Properties,Usage,Production
Description
Perospirone hydrochloride was launched in Japan as a new treatment of schizophrenia and other psychoses. This structurally-related analog of ziprasidone can be classically prepared by alkylation of 1-(3-benzisothiazolyl)-piperazine with the appropriate N- (chlorobutyl)-succinimide. As a result of an in vitro determination of its binding profile, perospirone demonstrated a high affinity for 5-HT2, 5-HT1A and D2 receptors as well as a significant but lower affinity for DI and al receptors. Interestingly, these differential effects on neurotransmitters with a high in vivo occupancy of 5-HT2A receptors with lower D2 occupancy seems to provide this new agent with a significantly lower propensity for the development of extrapyramidal symptoms (EPS) and tardive schizophrenia, the main sideeffects associated with classical antipsychotic therapy. Furthermore, perospirone exhibited anxiolytic-like effects in animal models. A long-term clinical trial (> 6 months) in a group of patients suffering from schizophrenia demonstrated the efficacy of perospirone over placebo for the treatment of the positive, negative and general symptoms of schizophrenia at doses of 12 mg to 96 mg t.i.d.
Originator
Sumitomo Pharm. (Japan)
Definition
ChEBI: (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione is a N-arylpiperazine.
brand name
Lullan
PEROSPIRONE Preparation Products And Raw materials
Raw materials
Preparation Products
PEROSPIRONE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71