PEROSPIRONE

ChemicalBook > CAS DataBase List > PEROSPIRONE

Product Name: PEROSPIRONE
CAS No.: 150915-41-6
Chemical Name: PEROSPIRONE
Synonyms: Perospirine;PEROSPIRONE;PEROSPIRONE HCL;[14C]-Perospirone;PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone;cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide;(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide;1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-;(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione;(3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
CBNumber: CB3101658
Molecular Formula: C23H30N4O2S
Formula Weight: 426.57
MOL File: 150915-41-6.mol

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PEROSPIRONE Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P288903
Product name: Perospirone
Packaging: 10mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: M813
Product name: Perospirone
Packaging: 25mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-0019906
Product name: Perospirone
Purity: 99.51%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008732
Product name: PEROSPIRONE
Purity: 95.00%
Packaging: 25MG
Price: $225.75
Updated: 2021/12/16

ChemScene

Product number: CS-0019906
Product name: Perospirone
Purity: 99.51%
Packaging: 50mg
Price: $420
Updated: 2021/12/16

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PEROSPIRONE Chemical Properties,Usage,Production

Description

Perospirone hydrochloride was launched in Japan as a new treatment of schizophrenia and other psychoses. This structurally-related analog of ziprasidone can be classically prepared by alkylation of 1-(3-benzisothiazolyl)-piperazine with the appropriate N- (chlorobutyl)-succinimide. As a result of an in vitro determination of its binding profile, perospirone demonstrated a high affinity for 5-HT₂, 5-HT_1A and D₂ receptors as well as a significant but lower affinity for DI and al receptors. Interestingly, these differential effects on neurotransmitters with a high in vivo occupancy of 5-HT_2A receptors with lower D₂ occupancy seems to provide this new agent with a significantly lower propensity for the development of extrapyramidal symptoms (EPS) and tardive schizophrenia, the main sideeffects associated with classical antipsychotic therapy. Furthermore, perospirone exhibited anxiolytic-like effects in animal models. A long-term clinical trial (> 6 months) in a group of patients suffering from schizophrenia demonstrated the efficacy of perospirone over placebo for the treatment of the positive, negative and general symptoms of schizophrenia at doses of 12 mg to 96 mg t.i.d.

Originator

Sumitomo Pharm. (Japan)

Definition

ChEBI: (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione is a N-arylpiperazine.

brand name

Lullan

PEROSPIRONE Preparation Products And Raw materials

Raw materials

Preparation Products

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150915-41-6, PEROSPIRONERelated Search:

1,2-Cyclohexanedicarboximide 1,2-Cyclohexanedicarboximide etisazole PEROSPIRONE 3-Piperazinobenzisothiazole hydrochloride PEROSPIRONE HYDROCHLORIDE DIHYDRATE,PEROSPIRONE HYDROCHLORIDE HYDRATE,PEROSPIRONE HYDROCHLORIDE,Perospirone Hydrochloride Trihydrate cis-Octahydroisoindole 1,2-Benzisothiazol-3-amine

PEROSPIRONE

PEROSPIRONE HCL

1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- (9CI)

1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-

cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide

Perospirine

(3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione

(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide

(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione

(3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione

[14C]-Perospirone

1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel-

PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone

deficits,atypical,Perospirone,SM-9018,Dopamine Receptor,5-hydroxytryptamine Receptor,5-HT Receptor,Orally,SM9018,schizophrenic,disease,Serotonin Receptor,cognitive,Inhibitor,SM 9018,inhibit,antipsychotic

150915-41-6

C23H30N4O2S