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BEPOTASTINE

Product Name
BEPOTASTINE
CAS No.
125602-71-3
Chemical Name
BEPOTASTINE
Synonyms
BEPOTASTINE;Bestatin (i.e;Bepotastine >(S)-Bepotastine;Bepotastine >90%;betotastine besilate;Bepotastine free base;-4-(4-((4-Chlorophenyl);(190786-43-7) bepotastine;Bepotastine, 10 mM in DMSO
CBNumber
CB3102554
Molecular Formula
C21H25ClN2O3
Formula Weight
388.89
MOL File
125602-71-3.mol
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BEPOTASTINE Property

Melting point:
56 - 58°C
Boiling point:
546.8±50.0 °C(Predicted)
Density 
1.26
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.44±0.10(Predicted)
form 
Solid
color 
White to Pale Beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B316095
Product name
Bepotastine>90%
Packaging
5mg
Price
$115
Updated
2021/12/16
ChemScene
Product number
CS-M1828
Product name
Bepotastine
Purity
98.12%
Packaging
100mg
Price
$248
Updated
2021/12/16
ChemScene
Product number
CS-M1828
Product name
Bepotastine
Purity
98.12%
Packaging
250mg
Price
$498
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007090
Product name
BEPOTASTINE
Purity
95.00%
Packaging
5MG
Price
$501.71
Updated
2021/12/16
ChemScene
Product number
CS-M1828
Product name
Bepotastine
Purity
98.12%
Packaging
1g
Price
$900
Updated
2021/12/16
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BEPOTASTINE Chemical Properties,Usage,Production

Uses

Bepotastine is a histamine H1 receptor antagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).

Definition

ChEBI: An ether that is (S)-(4-chlorophenyl)(pyridin-2-yl)methanol in which the hydroxyl hydrogen is substituted by a 1-(3-carboxypropyl)piperidin-4-yl group. A topical, selective and non-sedating histamine (H1) receptor anta onist used (as its benzenesulfonate salt) for treatment of itching associated with allergic conjunctivitis.

in vivo

Bepotastine (10 g/L; eye drop; 3 times at intervals of 20 min in one eye) demonstrates significant inhibition of PAF-induced conjunctival eosinophil infiltration[1].
Bepotastine (3 mg/kg; p.o.; once) suppresses scratching behavior to a frequency of 59.0 and a duration of 14.57 seconds, which are almost the same levels compares with the control[3].
Bepotastine (10 mg/kg; p.o.; once) significantly suppresses serum LTB 4 levels to 711.3 pg/mL at 1 h and 858.8 pg/mL at 2 h in NC/Nga mice with a rash[3].

Animal Model:Guinea pigs (6-week-old)[1].
Dosage:10 g/L (1.0% (w/v)) for 10 μL.
Administration:Eye drop; 3 times at intervals of 20 min (in one eye).
Result:Inhibited PAF-induced conjunctival eosinophil infiltration.
Animal Model:Male BALB/c mice(12-week-old); NC/Nga mice[3].
Dosage:3, 10 mg/kg
Administration:Oral administration; once (1 h before induces scratching behavior of Male BALB/c mice).
Result:Significantly inhibited histamine-mediated scratching behavior in male BALB/c mice.
Significantly suppressed serum LTB 4 levels in NC/Nga mice with a rash.

IC 50

H1 Receptor

BEPOTASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BEPOTASTINE Suppliers

China 96 India 8 United States 8 Global 112
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
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61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
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62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
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58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
Beijing Lianben Pharm-Chemicals Tech. Co., Ltd
Tel
+86-10-83386766
Fax
+86-10-83386758
Email
sales@lianben.com
Country
China
ProdList
91
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58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
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View Lastest Price from BEPOTASTINE manufacturers

Moxin Chemicals
Product
Bepotastine 125602-71-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95
Supply Ability
10000000
Release date
2025-02-13
Zibo Hangyu Biotechnology Development Co., Ltd
Product
bepotastine 125602-71-3
Price
US $70.00-700.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-31
Zhuozhou Wenxi import and Export Co., Ltd
Product
BEPOTASTINE 125602-71-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

125602-71-3, BEPOTASTINERelated Search:

BEPOTASTINE BESILATE (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid Dapoxetine Lercanidipine Donepezil Posaconazole alpha-(4-chlorophenyl)pyridine-2-methanol BEPOTASTINE

  • 4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID
  • 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-
  • betotastine besilate
  • 4-[4-[(4-Chlorophenyl)pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
  • (+)-(S)-4-[4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid
  • 4-[(S)-(4-chlorophenyl)-2-pyridinylMethoxy]-
  • -4-(4-((4-Chlorophenyl)
  • BEPOTASTINE
  • (190786-43-7) bepotastine
  • Bepotastine free base
  • Bepotastine &gt
  • Bepotastine >90%
  • Bepotastine D4Q: What is Bepotastine D4 Q: What is the CAS Number of Bepotastine D4 Q: What is the storage condition of Bepotastine D4 Q: What are the applications of Bepotastine D4
  • (S)-Bepotastine
  • Bestatin (i.e
  • Bepotastine, 10 mM in DMSO
  • 125602-71-3