ChemicalBook > CAS DataBase List > Beta-mangostin

Beta-mangostin

Product Name: Beta-mangostin
CAS No.: 20931-37-7
Chemical Name: Beta-mangostin
Synonyms: β-Mangostin;Beta-mangostin;shanzhuguoduofen;MANGOSTIN, BETA-;beta-Mangostin, >98%;Beta-mangostin USP/EP/BP;Keywords Dianthus extract;Beta-mangostin β-Mangostin;Beta-mangostin, 10 mM in DMSO;β-Mangostin, 98%, from Garcinia mangostana L.
CBNumber: CB31040699
Molecular Formula: C25H28O6
Formula Weight: 424.49
MOL File: 20931-37-7.mol

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Beta-mangostin Property

Melting point:: 175-176℃
Boiling point:: 616.5±55.0 °C(Predicted)
Density: 1.212
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
pka: 7.05±0.20(Predicted)
color: Yellow
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25071
Product name: β-Mangostin
Purity: ≥95%
Packaging: 1mg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 25071
Product name: β-Mangostin
Purity: ≥95%
Packaging: 5mg
Price: $965
Updated: 2024/03/01

Cayman Chemical

Product number: 25071
Product name: β-Mangostin
Purity: ≥95%
Packaging: 10mg
Price: $1448
Updated: 2024/03/01

TRC

Product number: M163895
Product name: β-Mangostin
Packaging: 1mg
Price: $250
Updated: 2021/12/16

ApexBio Technology

Product number: N2216
Product name: Beta-mangostin
Packaging: 20mg
Price: $200
Updated: 2021/12/16

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Beta-mangostin Chemical Properties,Usage,Production

Description

β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites. It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC₅₀ = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml). β-Mangostin inhibits fatty acid synthase (FASN) with an IC₅₀ value of 24.83 μM. It induces cell cycle arrest at the G₂/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells. β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E₂ (PGE₂; ) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.

Uses

β-Mangostin is isolated from the stem bark of Garcinia mangostana L. which shows significant cytotoxicities and anti-inflammatory activities against the LPS-induced RAW cell 264.7. Also, it demonstrates anti-metastatic activity against human hepatocellular carcinoma (HCC) cells, which may act as a promising therapeutic agent for the treatment of HCC.

Definition

ChEBI: Beta-Mangostin is a member of xanthones.

IC 50

Plasmodium

References

[1] MUNEKAZU IINUMA. Antibacterial Activity of Xanthones from Guttiferaeous Plants against Methicillin-resistant Staphylococcus aureus[J]. Journal of Pharmacy and Pharmacology, 1996, 48 8: 861-865. DOI: 10.1111/j.2042-7158.1996.tb03988.x
[2] K LIKHITWITAYAWUID J K T Phadungcharoen. Antimalarial xanthones from Garcinia cowa.[J]. Planta medica, 1998, 64 1: 70-72. DOI: 10.1055/s-2006-957370
[3] SUNIT SUKSAMRARN. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.[J]. Chemical & pharmaceutical bulletin, 2003, 51 7: 857-859. DOI: 10.1248/cpb.51.857
[4] HE ZHONG JIANG . Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 20: Pages 6045-6047. DOI: 10.1016/j.bmcl.2010.08.061
[5] SUVITHA SYAM . β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells[J]. Journal of Functional Foods, 2014, 6: Pages 290-304. DOI: 10.1016/j.jff.2013.10.018
[6] SUVITHA SYAM . β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo[J]. Journal of ethnopharmacology, 2014, 153 2: Pages 435-445. DOI: 10.1016/j.jep.2014.02.051

Beta-mangostin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Beta-mangostin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Beta-Mangostin 20931-37-7
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

Shanghai Standard Technology Co., Ltd.

Product: β-mangostin 20931-37-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥95%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-10

Career Henan Chemical Co

Product: Beta-mangostin 20931-37-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-10

20931-37-7, Beta-mangostinRelated Search:

Gamma-mangostin Mangostin 2-(4-METHYLPHENOXY)BENZENECARBALDEHYDE 2,4,4'-TRIHYDROXYBENZOPHENONE 2-HYDROXY-5-METHYLBENZOPHENONE 2,3',4,4',6-Pentahydroxybenzophenone 4,4'-Dihydroxybenzophenone 2,2',4,4'-Tetrahydroxybenzophenone GENTISIN 2,3',4,4'-TETRAHYDROXYBENZOPHENONE 2,2'-Dihydroxy-4-methoxybenzophenone PHLOROBENZOPHENONE 1,3-dihydroxyxanthone 2-HYDROXY-4,6-DIMETHOXY-3-METHYLACETOPHENONE GENTISEIN 2-ETHYL-4'-METHOXYBENZOPHENONE isogentisin Beta-mangostin

Beta-mangostin

1,6-Dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one

1,6-Dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Beta-mangostin β-Mangostin

β-Mangostin, 98%, from Garcinia mangostana L.

beta-Mangostin, >98%

Keywords Dianthus extract

shanzhuguoduofen

1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one

9H-Xanthen-9-one, 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-buten-1-yl)-

Beta-mangostin USP/EP/BP

1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-en-1-yl)-9...

β-Mangostin

1,6-Dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one

MANGOSTIN, BETA-

Beta-mangostin, 10 mM in DMSO

20931-37-7

reagent

standard substance