ChemicalBook > CAS DataBase List > Lisinopril Dihydrate

Lisinopril Dihydrate

Product Name
Lisinopril Dihydrate
CAS No.
83915-83-7
Chemical Name
Lisinopril Dihydrate
Synonyms
Lisinopril;Zestfil;renacor;isinopriL;Lisinopril API;(S) Lisinopril;L-154826：MK-521;LISINOPRIL HYDRATE;Lisinopril99%Assay;MK-521 (dihydrate)
CBNumber
CB3113756
Molecular Formula
C21H33N3O6
Formula Weight
423.51
MOL File
83915-83-7.mol
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Lisinopril Dihydrate Property

Melting point:
148 °C
alpha 
25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
refractive index 
-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
storage temp. 
2-8°C
solubility 
H2O: ≥10 mg/mL
form 
solid
pka
2.5, 4.0, 6.7, 10.1(at 25℃)
color 
white
Merck 
14,5516
Stability:
Hygroscopic
CAS DataBase Reference
83915-83-7(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) (83915-83-7)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22
Safety Statements 
22-24/25-36
WGK Germany 
3
RTECS 
TW3589990
HazardClass 
IRRITANT
HS Code 
2933995300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6292
Product name
Lisinopril
Purity
≥98% (HPLC)
Packaging
100mg
Price
$401
Updated
2024/03/01
Sigma-Aldrich
Product number
BP695
Product name
Lisinopril dihydrate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$262
Updated
2024/03/01
Sigma-Aldrich
Product number
1368609
Product name
Lisinopril
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
L0220
Product name
Lisinopril Dihydrate
Purity
>98.0%(T)
Packaging
1g
Price
$100
Updated
2024/03/01
TCI Chemical
Product number
L0220
Product name
Lisinopril Dihydrate
Purity
>98.0%(T)
Packaging
5g
Price
$299
Updated
2024/03/01
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Lisinopril Dihydrate Chemical Properties,Usage,Production

Description

Lisinopril is an angiotensin converting enzyme inhibitor structurally related to enalaprilat. It is reportedly useful in the management of hypertension and congestive heart failure.

Chemical Properties

White to Off-White Crystalline Powder

Originator

Merck (USA)

Uses

An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: Lisinopril dihydrate is a hydrate. It has a role as an antihypertensive agent. It contains a lisinopril.

brand name

Prinivil (Merck); Zestril (AstraZeneca).

General Description

Lisinopril, 1-[N2-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is alysine derivative of enalaprilat, the active metabolite ofenalapril. Like all ACE inhibitors, it is an active site-directedinhibitor of the enzyme, with the zinc ion used in an effectivebinding interaction at a stoichiometric ratio of 1:1. The pharmacologicaleffects of lisinopril are similar to those of captopriland enalapril.

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) inhibitor.

Clinical Use

Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.

Veterinary Drugs and Treatments

The principle uses of lisinopril in veterinary medicine at present are as a vasodilator in the treatment of heart failure or hypertension. Recent studies have demonstrated that ACE inhibitors, particularly when used in conjunction with furosemide, do improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. Lisinopril may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and in protein losing nephropathies.
Lisinopril may have advantages over other ACE inhibitors in that it may be dosed once daily and less expensive. Disadvantages are that it is only available in human labeled dosage forms and there is much less published information on its use (efficacy, safety, dosing) in veterinary species.

Lisinopril Dihydrate Preparation Products And Raw materials

Raw materials

Triethylamine hydrochloride Palladium carbon fine chemical catalyzer Polystyrene L-Lysine Trifluoroacetic acid Triethylamine Sodium bicarbonate Benzyl chloroformate Cyclohexylurea Sodium cyanoborohydride Magnesium sulfate Dicyclohexylcarbodiimide

Preparation Products

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View Lastest Price from Lisinopril Dihydrate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Lisinopril 83915-83-7
Price
US $30.00/g
Min. Order
10g
Purity
98%
Supply Ability
2000kg
Release date
2024-03-26
Shanghai Longyu Biotechnology Co., Ltd.
Product
Lisinopril 83915-83-7
Price
US $1.00/g
Min. Order
1g
Purity
99
Supply Ability
20tons
Release date
2022-01-18
Henan Fengda Chemical Co., Ltd
Product
Lisinopril Dihydrate 83915-83-7
Price
US $36.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16

83915-83-7, Lisinopril DihydrateRelated Search:

DL-Lysine acetylsalicylate Poly(L-lysine hydrobromide) L-Lysine hydrochloride L-Lysine D-Proline N6-TrifluoroAcetyl-L-Lysine,Lisinopril LISINOPRIL ESTER,LISINOPRIL (ETHYL) ESTER Lisinopril N∑-BENZYLOXYCARBONYL-L-LYSINYL-L-PROLINE(LISINOPRIL INTERMEDIATE) N6-TRIFLUOROACETYL-L-LYSINE /INTERMEDIATE OF LISINOPRIL N6-Trrifluoroacetyl-L-lysine(for Lisinopril),N-6-TRIFLUORO ACETYL-L-LYSINE ( LISINOPRIL INTERMEDIATE ),N6-Trifluoroacetyl-L-lysine (for lisinopril) Lisinopril R,S,S-Diketopiperazine Pyrazine Ethylbenzene LISINOPRIL DIHYDRATE FOR PERFORMANCE TEST FOROXYMITHINE (R) Lisinopril (S)Lisinopril-D5

  • Lisinopril Related Compound A (15 mg) ((S)-2-{(3S,8aS)-3-(4-aminobutyl)-1,4-dioxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl}-4-phenylbutanoic acid)
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  • LISINOPRIL-D5 HYDRATE
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  • (ds)-1-[n2-(1-carboxy-3-phenylpropyl)-l-prolinedihydrate
  • (s)-1-(n(sup2)-(1-carboxy-3-phenylpropyl)-l-lysyl)-l-prolinedihydrate
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  • L-154826：MK-521
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  • (2S)-1-[(2S)-6-Amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid dihydrate
  • (S)-(-)-1-[N-(1-Carboxy-3-phenylpropyl)-L-lysinyl]-L-proline dihydrate
  • Lisinopril,(S)-1-[N2-(1-carboxy-3-phenylpropyl)-lysyl-proline dihydrate, MK-521
  • Lisinopril (300 mg)
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  • (S) Lisinopril
  • (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]L-proline, Dihydrate, MK-521, Acerbon, Alapril, Carace, Coric, Novatec, Prinil, Prinivil, Tensopril, Vivatec, Zestril
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  • Lisinopril DihydrateQ: What is Lisinopril Dihydrate Q: What is the CAS Number of Lisinopril Dihydrate Q: What is the storage condition of Lisinopril Dihydrate
  • "Lisinopril for system suitability (Y0001235)"Q: What is "Lisinopril for system suitability (Y0001235)" Q: What is the CAS Number of "Lisinopril for system suitability (Y0001235)"
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  • Lisinopril diydrate
  • Lisinopril Dihydrate (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline Dihydrate
  • Lisinopril Dihydrate, ≥ 98.0%
  • 83915-83-7
  • C21H31O5N32H2O
  • C13H31N3O52H2O
  • C21H31N3O5